Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications

Giri, Tapan Kumar; Thakur, Deepa; Alexander, Amit; AJAZUDDIN, .; Badwaik, Hemant; Tripathi, Dulal Krishna

doi:10.2174/156720112803529800

Cited by 154 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds were similar to the living tissue because of their high-water capacity, penetrability, and consistency. Recently, a lot of research was done on the preparation of the transdermal membranes using polysaccharides [1][2][3]. Among the most widely proposed hydrophilic polymers in hydrogels preparation, polysaccharides had a number of benefits versus the synthetic polymers.…”

Section: Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

et al. 2020

View full text Add to dashboard Cite

Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structure without dissolving (Zhu and Marchant, Expert Rev Med Devices 8:607-626, 2011). Among the numerous polymers which have been utilized for the preparation of the hydrogels, polysaccharides have gained more attention in the area of pharmaceutics; Sodium alginate is a non-toxic, biocompatible, and biodegradable polysaccharide with several unique physicochemical properties for which has used as delivery vehicles for drugs (Kumar Giri et al., Curr Drug Deliv 9:539-555, 2012). Owing to their high-water content and resembling the natural soft tissue, hydrogels were studied a lot as a scaffold. The formation of hydrogels can occur by interactions of the anionic alginates with multivalent inorganic cations through a typical ionotropic gelation method. However, those applications require the control of some properties such as mechanical stiffness, swelling, degradation, cell attachment, and binding or release of bioactive molecules by using the chemical or physical modifications of the alginate hydrogel. In the current review, an overview of alginate hydrogels and their properties will be presented as well as the methods of producing alginate hydrogels. In the next section of the present review paper, the application of the alginate hydrogels will be defined as drug delivery vehicles for chemotherapeutic agents. The recent advances in the application of the alginate-based hydrogels will be describe later as a wound dressing and bioink in 3D bioprinting.

show abstract

Section: Hydrogelsmentioning

confidence: 99%

“…The cross-linking procedure is mainly achieved by the replacement of the sodium ions of G-blocks with the divalent cations such as Ca 2+ and bending of guluronic groups to create the structure like the egg box ( Fig. 4) [2]. Therefore, ALG gels with plenty of poly G-block units are known to be fragile, rigid, and mechanically more stable.…”

Section: Gel Formationmentioning

confidence: 99%

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

et al. 2020

View full text Add to dashboard Cite

show abstract

“…69 Alginate is a potential biodegradable polymer for cardiac tissue engineering because of its high biocompatibility, biodegradability, and non-toxicity, as well as its relatively economical, mild and physical gelation process, and non-thrombogenic nature. 37,39,70 Several methods such as crosslinking, immobilization of specific ligands, and the conjugation of other materials have been used for the modification of gelation and mechanical properties of alginate. 38 In one study, Sondermeijer et al modified an alginate scaffold with a covalently attached synthetic cyclic RGDfK (Arg-Gly-Asp-D-Phe-Lys)-peptide to improve the survival of transplanted cells and angiogenesis in damaged myocardium tissue.…”

Section: Alginatementioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

103

View full text Add to dashboard Cite

Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

show abstract

“…Hydrogel has been widely applied in drug releasing [14,15,16,17]. After being packed into the hydrogel, the releasing behavior of drugs can be controlled on the basis of the high design ability and fast substance exchange of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum

Xiang

Xie

et al. 2019

Molecules

View full text Add to dashboard Cite

Ralstonia solanacearum (R. solanacearum)-induced bacterial wilt of the nightshade family causes a great loss in agricultural production annually. Although there has been some efficient pesticides against R. solanacearum, inaccurate pesticide releasing according to the onset time of bacterial wilt during the use of pesticides still hinders the disease management efficiency. Herein, on the basis of the soil pH change during R. solanacearum growth, and pH sensitivity of the Schiff base structure, a pH-sensitive oxidized alginate-based double-crosslinked gel was fabricated as a pesticide carrier. The gel was prepared by crosslinking oxidized sodium alginate (OSA) via adipic dihydrazide (ADH) and Ca2+. After loading tetramycin into the gel, it showed a pH-dependent pesticide releasing behavior and anti-bacterial activity against R. solanacearum. Further study also showed that the inhibition rate of the tetramycin-loaded gel was higher than that of industrial pesticide difenoconazole. This work aimed to reduce the difficulty of pesticide administration in the high incidence period of bacterial wilt and we believe it has a great application potential in nightshade production.

show abstract

Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications

Cited by 154 publications

References 0 publications

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum

Contact Info

Product

Resources

About