Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum

Abstract

Ralstonia solanacearum (R. solanacearum)-induced bacterial wilt of the nightshade family causes a great loss in agricultural production annually. Although there has been some efficient pesticides against R. solanacearum, inaccurate pesticide releasing according to the onset time of bacterial wilt during the use of pesticides still hinders the disease management efficiency. Herein, on the basis of the soil pH change during R. solanacearum growth, and pH sensitivity of the Schiff base structure, a pH-sensitive oxidized alginate-based double-crosslinked gel was fabricated as a pesticide carrier. The gel was prepared by crosslinking oxidized sodium alginate (OSA) via adipic dihydrazide (ADH) and Ca2+. After loading tetramycin into the gel, it showed a pH-dependent pesticide releasing behavior and anti-bacterial activity against R. solanacearum. Further study also showed that the inhibition rate of the tetramycin-loaded gel was higher than that of industrial pesticide difenoconazole. This work aimed to reduce the difficulty of pesticide administration in the high incidence period of bacterial wilt and we believe it has a great application potential in nightshade production.

The Enhancement of Antiviral Activity of Chloroinconazide by Aglinate-based Nanogel and Its Plant Growth Promotion Effect

“…Many studies have shown that the sustained release of hydrogel-induced pesticides can remarkably improve the application efficiency of the pesticides. , Ma et al used a Schiff base to crosslink the oxidized alginate and fabricated a pH-sensitive hydrogel that could be used in soil-borne bacterial-derived plant diseases. The Schiff base crosslinking point would be broken under a low pH, and thus the drug loaded in the hydrogel would fastly release into the environment to respond to the growth of the bacteria . A new type of double cross-linked ADH-OSA gel with a pH-dependent pesticide release behavior has high antibacterial activity against Ralstonia solanacearum .…”

“…18,19 The Schiff base crosslinking point would be broken under a low pH, and thus the drug loaded in the hydrogel would fastly release into the environment to respond to the growth of the bacteria. 20 A new type of double cross-linked ADH-OSA gel with a pH-dependent pesticide release behavior has high antibacterial activity against Ralstonia solanacearum. 20 Although the advantage of hydrogels in the application of plant protection has been proved, bulk hydrogels have still not been used to control leaf diseases due to their large size.…”

Natural resources derived biocomposites as potential carriers of green pesticides in agricultural field: Designing and fabrication of a pot‐like device

“…50 The composite Pectin/HF-0.5 h showed the highest thermal stability, which could be attributed to the improved interaction fiber/matrix, which helped to delay the thermal decomposition of the pectin. 51,52 In fact, since the mechanochemical treatment removed external non-cellulosic materials, the roughness of treated HF surface tended to increase improving the interconnections between the HF and the polymeric matrix. The onset temperature tended to decrease as the processing time of HF treatment increased.…”

pH and Redox Dual-Responsive Mesoporous Silica Nanoparticle as Nanovehicle for Improving Fungicidal Efficiency

“…Therefore, improving the utilization of pesticides has been a crucial issue over the past decade. Recently, with the rapid development and application of nanotechnology in the agricultural field, a series of environmental-stimulus-responsive pesticide nanosystems [ 5 , 6 , 7 ], such as pH [ 8 , 9 , 10 ], temperature [ 11 , 12 , 13 , 14 ], enzyme [ 15 , 16 , 17 ], redox [ 18 , 19 , 20 ], and light-responsive materials [ 21 , 22 , 23 ], were developed to improve the utilization rate of pesticides and reduce environmental risk. However, to the best of our knowledge, few reports on dual-responsive pesticide delivery nanosystems exist.…”