Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing

Zhang, Miao; Qiao, Xiaoni; Han, Wenwei; Jiang, Tianze; Liu, Fei; Zhao, Xia

doi:10.1016/j.carbpol.2021.118100

Cited by 180 publications

(90 citation statements)

References 42 publications

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“…While CS is the polymer of interest illustrated in this review, similar functionalization strategies were reported for many other (bio)polymers and nanocomposites, including alg [ 83 ], HA [ 171 ], CNT [ 172 ], cyclodextrin polyester [ 173 ], and even proteins [ 174 ]. In these examples, non-functionalized CS is mixed to these polymers as adjuvants.…”

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 86%

“…Alternatively, sodium alginate (alg) can be employed for wound healing applications due to its water-retaining property. Its combination with COS allowed enhancement of the mechanical properties compared to pure alg hydrogels [ 83 ]. Regarding drug delivery, Gum Arabic multiple aldehyde was used as a non-toxic macromolecular CS cross-linker [ 43 ].…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…Encapsulation or coating of NPs is performed when the application involves non-solubilized films or beads. Metal NPs (AuNP [ 148 ] and AgNP [ 84 ]) and metal oxide NPs (ZnO [ 63 , 83 ] and Fe 3 O 4 [ 164 , 165 , 166 ]) were combined with CS-based polymers, providing stabilizing and anti-swelling effects as well as adding complementary features to the resulting conjugates, such as optical contrast, magnetization, or bactericide effect.…”

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 86%

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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“… Wang et al (2021b) reported an antibacterial hydrogel prepared by coupling vancomycin with silver nanoparticles. ZnO nanoparticles were also loaded in a hydrogel to endow it with the antibacterial ability ( Zhang M. et al, 2021 ). However, the abuse of antimicrobial agents, antibiotics, and metal nanomaterials may lead to drug resistance, making the drugs cytotoxic and limiting their potential applications ( Song et al, 2020 ).…”

Section: Functionalization Of Hydrogels For Wound Healingmentioning

confidence: 99%

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

et al. 2022

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Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

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“…Sodium alginate was oxidized to alginate aldehyde and spontaneously cross-linked with the amino group of COSs to form a Schiff base, and the ZnO nanoparticles were loaded to form sodium alginate-COS-zinc oxide (SA-COS-ZnO) composite hydrogel, which was used to promote wound healing [36].…”

Section: Alkylated Cos Derivativesmentioning

confidence: 99%

The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

Feng

You

et al. 2022

Marine Drugs

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Chitosan obtained from abundant marine resources has been proven to have a variety of biological activities. However, due to its poor water solubility, chitosan application is limited, and the degradation products of chitosan oligosaccharides are better than chitosan regarding performance. Chitosan oligosaccharides have two kinds of active groups, amino and hydroxyl groups, which can form a variety of derivatives, and the properties of these derivatives can be further improved. In this review, the key structures of chitosan oligosaccharides and recent studies on chitosan oligosaccharide derivatives, including their synthesis methods, are described. Finally, the antimicrobial and antitumor applications of chitosan oligosaccharides and their derivatives are discussed.

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Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing

Cited by 180 publications

References 42 publications

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

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