Alginate/chitosan polyelectrolyte complexes: A comparative study of the influence of the drying step on physicochemical properties

Conzatti, Guillaume; Faucon, Déborah; Castel, M.; Ayadi, Farouk; Cavalié, Sandrine; Tourrette, Audrey

doi:10.1016/j.carbpol.2017.05.023

Cited by 67 publications

(49 citation statements)

References 40 publications

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“…The morphology of dried films was evaluated using scanning electron microscopy (SEM) analysis. In general, the surface of F-Alg/Chito appeared compact and almost smooth ( Figure 1A) in accordance to the literature [45] for a xero-polyelectrolyte complex constituted by alginate and chitosan. In the case of F-Alg/Chito/BBS ( Figure 1B), several irregularities appeared, which increased by sample exposure to the electron beam, as indicated by the white arrows in the inset of Figure 1B, where the same region after brief and prolonged exposure to the beam is shown.…”

Section: Physicochemical Characterizationssupporting

confidence: 89%

The Innovation Comes from the Sea: Chitosan and Alginate Hybrid Gels and Films as Sustainable Materials for Wastewater Remediation

Tummino

Magnacca

Cimino

et al. 2020

IJMS

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The growing utilization of renewable and residual biomasses for environmental preservation and remediation are important goals to be pursued to minimize the environmental impact of human activities. In this paper, sodium alginate (derived from brown algae) was crosslinked using chitosan (mainly derived from the exoskeleton of crustaceans) in the presence of biowaste-derived substances isolated from green compost (BBS-GC), to produce hydrogels and dried films. The obtained materials were tested as adsorbents for wastewater remediation. To this purpose, gels were characterized using a multi-analytical approach and used as active substrates for the removal of three differently-charged molecules, chosen as model pollutants: crystal violet, rhodamine B, and orange II. The effectiveness of the gel formulations was demonstrated and attributed to the variety of active functionalities introduced by the different precursors, the structural factors and the peculiar physicochemical properties of the resulting materials.

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Section: Physicochemical Characterizationssupporting

confidence: 89%

The Innovation Comes from the Sea: Chitosan and Alginate Hybrid Gels and Films as Sustainable Materials for Wastewater Remediation

Tummino

Magnacca

Cimino

et al. 2020

IJMS

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“…The partial protonated amine groups of CS react with the carboxylate groups of ALG and thus strong polyelectrolyte complexes are formed. 35,36 P1 fibers were simultaneously cross-linked/ coated with calcium ions and CS. During cross-linking, fiber soaking into aqueous solutions causes the removal of PEO and surfactant.…”

Section: Discussionmentioning

confidence: 99%

Coated electrospun alginate-containing fibers as novel delivery systems for regenerative purposes

Vigani

Rossi

Sandri

et al. 2018

IJN

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AimThe aim of the present work was to develop biodegradable alginate (ALG)-containing fibrous membranes intended for tissue repair, acting as both drug delivery systems and cell growth guidance.MethodsMembranes were prepared by electrospinning. Since ALG can be electrospun only when blended with other spinnable polymers, dextran (DEX) and polyethylene oxide (PEO) were investigated as process adjuvants. ALG/DEX mixtures, characterized by different rheological and conductivity properties, were prepared in phosphate buffer or deionized water; surfactants were added to modulate polymer solution surface tension. The Design of Experiments (DoE) approach (full factorial design) was used to investigate the role of polymer solution features (rheological properties, surface tension, and conductivity) on electrospun fiber morphology. A high viscosity at 1,000 s−1 (1.3–1.9 Pa.s) or a high pseudoplasticity index (≥1.7), combined with a low surface tension (30–32 mN/m) and a low conductivity (800–1,000 μS/cm), was responsible for the production of ALG/DEX homogeneous fibers. Such ranges were successfully employed for the preparation of ALG-containing fibers, using PEO, instead of DEX, as process adjuvant. ALG/DEX and ALG/PEO fibers were subsequently subjected to cross-linking/coating processes to make them slowly biodegradable in aqueous medium. In particular, ALG/PEO fibers were cross-linked and coated with CaCl2/chitosan solutions in water/ethanol mixtures. Due to DEX high content, ALG/DEX fibers were soaked in a polylactide-co-glycolide (PLGA) solution in ethyl acetate.ResultsBoth cross-linking and coating processes made fibers insoluble in physiological medium and produced an increase in their mechanical resistance, assessed by means of a tensile test. PLGA-coated ALG/DEX and chitosan-coated ALG/PEO fibers were biocompatible and able to support fibroblast adhesion.ConclusionThe DoE approach allowed to draw up guidelines useful for the preparation of homogeneous fibers, starting from mixtures of ALG and non-ionic polymers. Such fibers, upon coating, resulted to be good cell substrates, allowing cell adhesion and growth.

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“…In addition, swelling ratio of hydrogel films in RAS therapy is an important parameter for mucoadhesive phenomena. Swollen polymers increase surface contact and mechanical entanglement for hydrogen bonding interactions between the polymer and mucous networks [37,38]. In this study, HFs were weighed and soaked in PBS pH 7.4 for two days.…”

Section: Swelling Abilitymentioning

confidence: 99%

“…In addition, Alg HF could not be weighed due to totally dissolved in PBS and did not remain a film formation, indicating that the Alg rapidly dissolve in saliva fluid. The swelling ability of ChAlg polyelectrolyte complexes related to the hydrophilic character of Alg that increase the porosity and surface area of the network leads to improve the swelling ratio of the HF [38,39]. In addition, heparin-based hydrogel containing epidermal growth factor immersed in PBS solution produced swelling values of 14.4 [40].…”

Section: Swelling Abilitymentioning

confidence: 99%

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

et al. 2019

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Featured Application: This study highlights a novel application of α-mangostin hydrogel film based chitosan-alginate. α-mangostin has been known as an agent for oral cavity therapy. However, α-mangostin is difficult to be delivered directly to the site. This novel application of hydrogel film-based chitosan-alginate have the potential as carriers of α-mangostin for recurrent aphthous stomatitis therapy.Abstract: Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan-alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan-alginate have the potential as carriers of α-M for RAS therapy.

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Alginate/chitosan polyelectrolyte complexes: A comparative study of the influence of the drying step on physicochemical properties

Cited by 67 publications

References 40 publications

The Innovation Comes from the Sea: Chitosan and Alginate Hybrid Gels and Films as Sustainable Materials for Wastewater Remediation

The Innovation Comes from the Sea: Chitosan and Alginate Hybrid Gels and Films as Sustainable Materials for Wastewater Remediation

Coated electrospun alginate-containing fibers as novel delivery systems for regenerative purposes

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

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