α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

Abstract

Featured Application: This study highlights a novel application of α-mangostin hydrogel film based chitosan-alginate. α-mangostin has been known as an agent for oral cavity therapy. However, α-mangostin is difficult to be delivered directly to the site. This novel application of hydrogel film-based chitosan-alginate have the potential as carriers of α-mangostin for recurrent aphthous stomatitis therapy.Abstract: Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan-alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan-alginate have the potential as carriers of α-M for RAS therapy.

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

“…The diffraction pattern of α-M/HP-β-CD PM displayed the same peak with α-M/ at 5° and 14°, indicating that the crystallinity was still detectable. This intense peak disappeared in α-M/HP-β-CD CX, indicating that α-M was probably entrapped in the cavity of HP-β-CD [ 17 , 23 ]. The spectra indicated that the interaction between α-M and HP-β-CD probably formed a number of hydrogen bonds and changed the physical characteristic of the drug in the complex [ 24 ].…”

Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

“…Chitosan is a deacetylation process derived from chitin and is composed of d -glucosamine and N-acetyl- d -glucosamine units linked to β-(1→4) [ 38 , 39 , 40 ]. Chitosan is one of the possible drug carrier nanoparticles (NPs) because of its biodegradability and biocompatibility and displayed non- or minimal toxicity [ 41 ].…”

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

“…The strong antioxidant activity in ulvan is able to make it a therapeutic agent [10,22,28,70] and in subsequent studies, the benefits of ulvan were investigated to have anti-inflammatory, anti-cancer, immunomodulatory, anti-hyperlipidemic, anti-bacterial, and anti-virus activities. Ulvan, which is composed most of polysaccharides, has the potential to be developed in biomedical formulations as polymers in hydrogel formulations [29]; this characteristic of ulvan polysaccharides is similar to that of alginate polymers [73]. Ulvan is also used in the field of tissue engineering for cartilage combined with poly (D-lactic acid) (PDLLA) [74].…”

“…Ulvan-based hydrogels can be used in cartilage tissue engineering [128]. Ulvan also contains polysaccharides that are similar to alginates, so it can be used as a hydrogel polymer [73]. Ulvan extracted from U. lactuca and chitosan extracted from Loligo forbesii squid-pen produced 98% carboxymethylated ulvan (CMU) and 87% carboxymethyl chitosan.…”