Alginate-coated chitosan nanoparticles act as effective adjuvant for hepatitis A vaccine in mice

AbdelAllah, Nourhan H.; Gaber, Yasser; Rashed, Mohamed E.; Azmy, Ahmed F.; Abou-Taleb, Heba A; AbdelGhani, Sameh

doi:10.1016/j.ijbiomac.2020.02.287

Cited by 52 publications

(31 citation statements)

References 34 publications

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“…In recent years, several studies involving nanoparticles have reported satisfactory results for the control of HBV-A and HBV-B A potential vaccine based in alginate-coated chitosan nanoparticles (ACNp) loaded with hepatitis B surface antibodies (HBsAg) and anchored with lipopolysaccharide, as adjuvant for oral mucosal immunization, showed that HBsAg was protected by the nanoparticles, and it was detected that a significant production of immunoglobulin A (sIgA) in mucosal, and IgG antibodies in blood circulation. [102] Similar results were reported by AbdelAllah et al, [103] where ACNp was evaluated as effective adjuvant for hepatitis A. Nanoparticle application in mice showed production of interferon gamma (INF-γ), interleukin-10 (IL-10), and an increase in seroconversion rate (100%), splenocyte proliferation, and hepatitis A antibodies level. Given that HBV can cause hepatocellular injury, polypeptide penetratin-based hybrid nanoparticle system carrying IL-22 gene demonstrated that locally IL-22 protein (interleukin-22) expression and activation of STAT3 signaling pathway allowed to repair hepatocyte injury.…”

Section: Nanoparticles For Hepatitis Virus Infectionsupporting

confidence: 74%

Advanced Material Against Human (Including Covid‐19) and Plant Viruses: Nanoparticles As a Feasible Strategy

et al. 2020

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The SARS‐CoV‐2 virus outbreak revealed that these nano‐pathogens have the ability to rapidly change lives. Undoubtedly, SARS‐CoV‐2 as well as other viruses can cause important global impacts, affecting public health, as well as, socioeconomic development. But viruses are not only a public health concern, they are also a problem in agriculture. The current treatments are often ineffective, are prone to develop resistance, or cause considerable adverse side effects. The use of nanotechnology has played an important role to combat viral diseases. In this review three main aspects are in focus: first, the potential use of nanoparticles as carriers for drug delivery. Second, its use for treatments of some human viral diseases, and third, its application as antivirals in plants. With these three themes, the aim is to give to readers an overview of the progress in this promising area of biotechnology during the 2017–2020 period, and to provide a glance at how tangible is the effectiveness of nanotechnology against viruses. Future prospects are also discussed. It is hoped that this review can be a contribution to general knowledge for both specialized and non‐specialized readers, allowing a better knowledge of this interesting topic.

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Section: Nanoparticles For Hepatitis Virus Infectionsupporting

confidence: 74%

Advanced Material Against Human (Including Covid‐19) and Plant Viruses: Nanoparticles As a Feasible Strategy

et al. 2020

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“…The numerous recent hepatitis A outbreaks emphasize the need for vaccination; despite the effectiveness of the current vaccination, further development is needed to overcome its high cost plus some immune response limitations. AbdelaAllah et al [212] evaluated the use of CS and ALG-coated CS NPs as an adjuvant/carrier for the hepatitis A (HA) vaccine against the traditional adjuvant alum (AL). Immune responses towards the HA-AL, HA-CS, and HA-ALG/CS NPs were assessed in mice.…”

Section: Vaccine Deliverymentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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“…In a recent study, an effective adjuvant for Hepatitis A vaccine was used and compared with traditional alum adjuvant [ 34 ]. The immune response of vaccines was evaluated.…”

Section: The Role Of Alginate-based Adjuvant and Vaccine Delivery System For Pandemic Strainsmentioning

confidence: 99%

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

Mallakpour

Azadi

Hussain

2021

International Journal of Biological Macromolecules

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Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery system is opening up novel probabilities to make more immunization. Indeed, vaccination is the most successful way to prevent deaths from infectious diseases. In order to optimal immune response production or improvement in the effectiveness of vaccines, delivery systems or adjuvants are required. Natural polymers such as chitosan, alginate, hyaluronic acid, gums, and β-glucan with antiviral activity have good potential as adjuvant or delivery systems for vaccine formulation development and design vaccine delivery devices. According to the antiviral performance and immunomodulation of these biopolymers, they will play significant characters in the anti-COVID-19 field. In this mini-review, the recent progress in vaccine development by using biopolymers is presented which, provides a reference for their research on anti-COVID-19 drugs and vaccines.

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Alginate-coated chitosan nanoparticles act as effective adjuvant for hepatitis A vaccine in mice

Cited by 52 publications

References 34 publications

Advanced Material Against Human (Including Covid‐19) and Plant Viruses: Nanoparticles As a Feasible Strategy

Advanced Material Against Human (Including Covid‐19) and Plant Viruses: Nanoparticles As a Feasible Strategy

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

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