Alginate dressings for venous leg ulcers

O’Meara, Susan; James, Marrissa Martyn-St; Adderley, Una

doi:10.1002/14651858.cd010182.pub3

Cited by 49 publications

(35 citation statements)

References 55 publications

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“…Topical agents applied as a primary dressing; and a range of agents have been considered to promote the healing process . However, there is low to very low quality evidence regarding the effectiveness of most of these topical agents, except for cadexomer iodine . Autologous platelet‐rich plasma (PRP) has been used for 30 years in a variety of surgical situations, including blood loss reduction and promotion of tissue regeneration .…”

Section: Introductionmentioning

confidence: 99%

Adjuvant therapies in venous leg ulcer management: A scoping review

Team

Chandler

Weller

2019

Wound Repair Regeneration

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Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU); however, adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomized Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according to the management approaches, including (1) pharmaceutical interventions, (2) surgical interventions, (3) topical agents, (4) the use of devices, and (5) other, such as physiotherapy and psychological interventions. Results of this scoping review indicate that there is a limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the lowquality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardizing reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.

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Section: Introductionmentioning

confidence: 99%

Adjuvant therapies in venous leg ulcer management: A scoping review

Team

Chandler

Weller

2019

Wound Repair Regeneration

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“…In making decisions regarding dressing product selection, clinicians should consider the patient's comorbid conditions, wound assessment, dressing properties and cost (Dumville et al, 2013d;Dumville et al, 2015a;O'Meara et al, 2015) guided by evidence based wound management guidelines (Franks et al, 2016), which offer optimal and cost-effective care to help clinicians optimize healing outcomes in clinical practice . The main contribution of this review is that it compiled the latest available evidence of effectiveness for the major groups of first-line dressings and provided a comprehensive discussion of the main disadvantages, contraindications, and precautions that can guide health professionals in decision making on dressing selection in addition to the clinical practice guideline recommendations.…”

Section: Discussionmentioning

confidence: 99%

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician knowledge of dressing properties in wound care. Optimal wound management depends on accurate patient assessment, wound diagnosis, clinicians' knowledge of the wound healing process and properties of wound dressings. We conducted a comprehensive review of the physical properties of wound dressing products, including the advantages and disadvantages, indications and contraindications and effectiveness of first-line interactive/bioactive dressing groups commonly used in clinical practice. These include semipermeable films, foams, hydroactives, alginates, hydrofibers, hydrocolloids, and hydrogels. In making decisions regarding dressing product selection, clinicians need to ensure a holistic assessment of patient and wound etiology, and understand dressing properties when making clinical decisions using wound management guidelines to ensure optimal patient outcomes. This review has highlighted there is lack of high quality evidence and the need for future well designed trials.

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“…14,15 RCTs are particularly important in the field of venous leg ulcer (VLU) management, where there is minimal or no evidence of effectiveness of adjuvant treatments to compression therapy. 16,17 For example, the results of many systematic reviews [18][19][20][21][22] conducted in the field of VLU management report that much of the evidence of effectiveness of adjuvant therapies is limited or inconclusive. The researchers who conducted these systematic reviews linked their conclusion to the lack of RCTs in wound care and low quality of the available RCTs included in their review.…”

Section: Introductionmentioning

confidence: 99%

Randomised controlled trials as part of clinical care: A seven‐step routinisation framework proposal

Team

Weller

2018

International Wound Journal

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Evidence translation in wound care relies on the need for evidence generation. Clinical practice may generate evidence only if evidence‐generating research projects, such as randomised controlled trials (RCTs), became routinised in clinical settings. The aim of this study was to identify optimal trial‐related practices to routinise trial‐related activities in Melbourne‐located wound clinics as reported by clinicians and researchers. We conducted a secondary analysis of the available data on how to routinise RCTs in clinical care, with a focus on enablers and suggestions provided by the participants during face‐to‐face and telephone interviews. Data were obtained from a qualitative observational study nested within a randomised, double‐blinded, placebo‐controlled trial on clinical effectiveness of aspirin as an adjunct to compression therapy in healing chronic venous leg ulcers (ASPiVLU). We developed a seven‐step Routinisation of Trials in Clinical Care Framework. These steps include: (1) pre‐trial clinical site assessment, (2) optimising pre‐recruitment arrangements, (3) developing and updating trial‐related skills, (4) embedding RCT recruitment as part of routine clinical care, (5) promoting teamwork and trial‐related collaboration, (6) addressing trial‐related financial issues, and (7) communicating trial results to clinicians.

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Alginate dressings for venous leg ulcers

Cited by 49 publications

References 55 publications

Adjuvant therapies in venous leg ulcer management: A scoping review

Adjuvant therapies in venous leg ulcer management: A scoping review

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

Randomised controlled trials as part of clinical care: A seven‐step routinisation framework proposal

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