Alginate hydrogel-coated syringe needles for rapid haemostasis of vessel and viscera puncture

Ren, Junfeng; Yin, Xingjie; Chen, Yu; Su, Hua; Wang, Ke; Lian-bin, Zhang; Zhu, Jintao; Zhang, Chun

doi:10.1016/j.biomaterials.2020.120019

Cited by 28 publications

(23 citation statements)

References 42 publications

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“…Store the solution 48 h at room temperature before coating the needles. Then prepare the haemostatic needles as we described previously [ 17 ]. Amounts of Gel-TA solution was according to the gauge values of different commercial syringe needles: 18 G with 20 μL, 22 G with 4.5 μL, 25 G with 3 μL and 30 G 2 μL.…”

Section: Methodsmentioning

confidence: 99%

“…Among the recently developed haemostatic strategies, in situ haemostasis by functionalized needles is attracting growing interest, as these needles can achieve synchronous, effective, and complete haemostasis after needle extraction, regardless of whether the patients have coagulation dysfunction, and can avoid postoperative complications [ 12 , 15 ]. Haemostatic needles are usually obtained by coating the needle surface with hydrogels, such as catechol/Lys-conjugated chitosan, chitosan-catechol-poly ( N -isopropyl acrylamide), and alginate-CaCl 2 -based hydrogels, which can undergo an in situ solid-to-hydrogel phase transition to physically seal puncture wounds and achieve haemostasis after tissue puncture [ [15] , [16] , [17] ]. Recently, Lee et al reported haemostatic needles coated with partially crosslinked catechol-functionalized chitosan and showed immediate and complete haemostasis after vein puncture [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture

Yin

Ren

Lan

et al. 2022

Bioactive Materials

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture

Yin

Ren

Lan

et al. 2022

Bioactive Materials

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“…Ren et al developed hemostatic needles coatings with alginate-CaCl 2 -based hydrogels, which can effectively prevent hemorrhage following tissue puncture ( Figure 6 and Figure 7 ) [ 103 ]. The dry-formed hydrogels coatings on the needles can be converted into hydrogels upon hydration, and the adhesion of the hydrogels to the wound would be increased so that the hydrogels were separated from the needles when the needles were withdrawn and sealed the wound in situ.…”

Section: Hemostasis Of Vessel and Visceramentioning

confidence: 99%

Application of Alginate-Based Hydrogels in Hemostasis

Xie

Gao

et al. 2022

Gels

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Hemorrhage, as a common trauma injury and clinical postoperative complication, may cause serious damage to the body, especially for patients with huge blood loss and coagulation dysfunction. Timely and effective hemostasis and avoidance of bleeding are of great significance for reducing body damage and improving the survival rate and quality of life of patients. Alginate is considered to be an excellent hemostatic polymer-based biomaterial due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, easy gelation and easy availability. In recent years, alginate hydrogels have been more and more widely used in the medical field, and a series of hemostatic related products have been developed such as medical dressings, hemostatic needles, transcatheter interventional embolization preparations, microneedles, injectable hydrogels, and hemostatic powders. The development and application prospects are extremely broad. This manuscript reviews the structure, properties and history of alginate, as well as the research progress of alginate hydrogels in clinical applications related to hemostasis. This review also discusses the current limitations and possible future development prospects of alginate hydrogels in hemostatic applications.

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“…By coating syringe needles with hemostatic hydrogels, Ren et al prepared a kind of hemostatic needles. The Alginate-based hydrogel (Alg-Ca) would detach from the surface of the needle and stay at the puncture site, preventing further bleeding ( Ren et al, 2020 ). The hemostatic capability of the hydrogel-coated needles in the blood vessel puncture was tested by models of rat external jugular vein and rabbit ear vein, and in viscera puncture was tested by rat kidney and liver.…”

Section: Polysaccharide-based Hemostatic Hydrogelsmentioning

confidence: 99%

Section: Polysaccharide-based Hemostatic Hydrogelsmentioning

confidence: 99%

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.

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Alginate hydrogel-coated syringe needles for rapid haemostasis of vessel and viscera puncture

Cited by 28 publications

References 42 publications

Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture

Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture

Application of Alginate-Based Hydrogels in Hemostasis

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

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