Application of Alginate-Based Hydrogels in Hemostasis

Abstract

Hemorrhage, as a common trauma injury and clinical postoperative complication, may cause serious damage to the body, especially for patients with huge blood loss and coagulation dysfunction. Timely and effective hemostasis and avoidance of bleeding are of great significance for reducing body damage and improving the survival rate and quality of life of patients. Alginate is considered to be an excellent hemostatic polymer-based biomaterial due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, easy gelation and easy availability. In recent years, alginate hydrogels have been more and more widely used in the medical field, and a series of hemostatic related products have been developed such as medical dressings, hemostatic needles, transcatheter interventional embolization preparations, microneedles, injectable hydrogels, and hemostatic powders. The development and application prospects are extremely broad. This manuscript reviews the structure, properties and history of alginate, as well as the research progress of alginate hydrogels in clinical applications related to hemostasis. This review also discusses the current limitations and possible future development prospects of alginate hydrogels in hemostatic applications.

Design and evaluation of sodium alginate-based hydrogel dressings containing Betula utilis extract for cutaneous wound healing

“…This was attributed to multiple reasons as hydrogels are three-dimensional structures that provide optimum moisture, mimic the skin, act as a barrier for invading microorganism, and, more importantly, can be easily removed from wounds without damaging underlying cells (Khan et al, 2021). Furthermore, sodium alginate also contributes Frontiers in Bioengineering and Biotechnology frontiersin.org to hemostasis and wound healing due to good biocompatibility, mucoadhesion, high swelling, and oxygen permeability (Aderibigbe and Buyana, 2018;Xie et al, 2022). The literature survey revealed that phytochemical constituents, such as flavonoids and triterpenoids, are known to promote the wound healing process owing to astringent and antimicrobial properties.…”

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

“…Alginate is a natural anionic polymer derived mainly from brown algae found in the ocean. Alginate is a copolymer with L-gulo-glucuronide (G) and D-mannuronic acid (M) structural units with either continuous G chain segments (GGGG) and M chain segments (MMMM) or alternating MGMG chain segments [ 168 , 169 ]. It is currently believed that only the G unit is involved in the multivalent ion-induced crosslinking of alginate and that a high G content can improve the mechanical strength of a hydrogel.…”

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