Alginate in Bone Tissue Engineering

Rajesh, Rajendiran; Ravichandran, Y. Dominic; Kuo, Yung‐Chih

doi:10.1016/b978-0-12-809816-5.00019-0

Cited by 5 publications

(3 citation statements)

References 105 publications

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“…The amount of formed bone was greater in group I scaffolds than hydroxyapatite-loaded scaffolds-group II and this was confirmed by the histomorphometric analysis of this study which revealed statistically significant difference between the two groups. The high bone forming ability of group I (CS/ALG) shown in this study agreed with RajendiranRajesh et al (2017) who proved that alginate is important for the production of 3D scaffold materials in bone tissue engineering because it mimics the natural extracellular matrix, and that bone forming osteoblast cells rapidly adhered to the chitosan-alginate scaffold and proliferated well (30). It also enhances osteogenic development and mineralization, as well as preventing inflammatory responses (31).…”

Section: Discussionsupporting

confidence: 88%

3D PRINTING AND CHARACTERIZATION OF POROUS CHITOSAN BASED NANOCOMPOSITE SCAFFOLDS FOR BONE REGENERATION (IN VITRO and IN VIVO STUDY)

Abo Dahab,

Hanafy,

AlY

et al. 2023

Alexandria Dental Journal

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INTRODUCTION:Bone regeneration still is a challenging task for the maxillofacial surgeon. Autografts and allografts were two extensively used procedures for bone repair in the past. Tissue engineering is a promising method for employing biomaterials to repair, regenerate, preserve, and enhance the function of injured cells or tissues. Bone scaffold should be designed precisely fitting the 3D shape of the recipient site. AIM OF THE STUDY:The aim of this study was to prepare and characterize chitosan-based hydrogel scaffolds made of chitosan/alginate and chitosan/alginate/nano-hydroxyapatite fabricated by 3D printing and we compared the efficacy of both scaffolds on bone regeneration in a rabbit model. MATERIALS & METHODS:Chitosan-based nanocomposite hydrogel scaffolds were prepared and fabricated by 3D printing. Group I: chitosan/ alginate (control group) and group II: chitosan/ alginate/ nano-hydroxyapatite. Each of the two groups were characterized for in-vitro cytotoxicity, swelling kinetics, hydrolytic degradation, and Fourier Transform Infrared (FTIR). Moreover, the ability of these hydrogel scaffolds to enhance bone regeneration in a rabbit model was performed after 8 weeks using histological analysis. RESULTS: Cell viability results showed no cytotoxicity in either blank (group I) or loaded scaffolds (group II) on fibroblast cells after culture for 24h, 48h & 72h. Group I exhibited higher swelling rate after 5 days. Also, it demonstrated higher degradation rate compared to group II after 28 days. Histological examination of CS/AlG revealed higher bone formation (34%) compared to the HAP loaded scaffolds (26%). CONCLUSION: 3D printed custom-made porous CS/ALG and CS/ALG/HAP scaffolds showed good physical properties and bone regeneration. However, CS/ALG group showed enhanced bone formation compared HAP loaded scaffolds.

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Section: Discussionsupporting

confidence: 88%

3D PRINTING AND CHARACTERIZATION OF POROUS CHITOSAN BASED NANOCOMPOSITE SCAFFOLDS FOR BONE REGENERATION (IN VITRO and IN VIVO STUDY)

Abo Dahab,

Hanafy,

AlY

et al. 2023

Alexandria Dental Journal

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“…Sodium alginate (ALG) is a naturally occurring polymeric polysaccharide derived mainly from brown algae and consists of the basic structural units ß-D-mannuronic acid (M-unit) and α-Lguluronic acid (G-unit) linked by glycosidic linkages (Varaprasad et al, 2020;Zhang and Zhao, 2020). Sodium alginate has a similar molecular structure to the human extracellular matrix (ECM) and can be fabricated into a three-dimensional scaffold material as a supportive matrix for wound repair (Venkatesan et al, 2015;Rajesh et al, 2017). In addition, it is widely used in biomedical fields such as slow-release drug delivery and tissue engineering due to its easy accessibility, safety, non-toxicity, high stability and plasticity (Varaprasad et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds

Chen,

Qian,

Peng

et al. 2024

Front. Bioeng. Biotechnol.

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Wound infection is a major problem faced during wound healing. Therefore, it is necessary to develop wound dressings with excellent antimicrobial properties. Here, a smart response system of PVA-TPE/HA-AMP/SF/ALG wound dressing was prepared by a combination of chemical cross-linking and freeze-drying methods. We grafted AMP onto HA to endow the wound dressing with bacterial resistance and slow release of AMP. At the same time, the system detects bacterial activity in real time for precise antimicrobial activity (through the use of PVA-TPE) and modulates inflammation to reduce bacterial infection (through the use of AMP). In addition, the PVA-TPE/HA-AMP/SF/ALG wound dressing has a good three-dimensional mesh structure, which promotes cell proliferation, enhances collagen deposition and angiogenesis, and thus effectively promotes rapid healing of infected wounds. Moreover, it can induce the expression of inflammatory factors such as VEGF, TNF-α, IFN-γ, IL-4 and TGF-β1 in infected wounds through the Wnt/CAMK/p-PKC signaling pathway, inhibit inflammatory responses, promote wound healing and reduce scar formation. Therefore, the PVA-TPE/HA-AMP/SF/ALG wound dressing smart response system shows great promise in infected wound healing.

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“…22 Especially, the 3D multiscale carbon-based formations were recently recognized as particularly interesting for bone tissue engineering applications owing to their exceptional mechanical and biological properties. [22][23][24][25] Bone is an electroactive and well-organized structure that spans a range of scales from the nanoscale to the microscale. 16 Thus, a three-dimensional bioactive carbonbased scaffold seems to be very promising for its regeneration.…”

Section: Introductionmentioning

confidence: 99%

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

et al. 2023

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Alginate in Bone Tissue Engineering

Cited by 5 publications

References 105 publications

3D PRINTING AND CHARACTERIZATION OF POROUS CHITOSAN BASED NANOCOMPOSITE SCAFFOLDS FOR BONE REGENERATION (IN VITRO and IN VIVO STUDY)

3D PRINTING AND CHARACTERIZATION OF POROUS CHITOSAN BASED NANOCOMPOSITE SCAFFOLDS FOR BONE REGENERATION (IN VITRO and IN VIVO STUDY)

Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

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