Alginate: Pharmaceutical and Medical Applications

Batista, Patrícia; Morais, A. M. M. B.; Pintado, Manuela; Morais, Rui

doi:10.1007/978-3-030-12919-4_16

Cited by 28 publications

(16 citation statements)

References 264 publications

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“…An interesting example of a biodegradable polymer is sodium alginate, which in its chemical structure is based on interconnected units of β-d-mannuronic acid and α-1-guluronic acid [ 21 , 22 , 23 , 24 ]. Plastic composites created with the use of sodium alginate have found application in numerous economic fields, including production of modern food packaging, in medicine, tissue engineering, in pharmacy, medicaments production and biotechnology [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Biodegradable Silver Nanoparticle Foils Based on Various Strains of Pathogenic Bacteria Isolated from the Oral Cavity of Cats, Dogs and Horses

Rutkowski

Krzemińska-Fiedorowicz

Khachatryan

et al. 2022

Materials

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Frequent occurrence of microbial resistance to biocides makes it necessary to find alternative antimicrobial substances for modern veterinary medicine. The aim of this study was to obtain biodegradable silver nanoparticle-containing (AgNPs) foils synthesized using non-toxic chemicals and evaluation of their activity against bacterial pathogens isolated from oral cavities of cats, dogs and horses. Silver nanoparticle foils were synthesized using sodium alginate, and glucose, maltose and xylose were used as reducing agents. The sizes of AgNPs differed depending on the reducing agent used (xylose < maltose < glucose). Foil without silver nanoparticles was used as control. Bacterial strains were isolated from cats, dogs and horses by swabbing their oral cavities. Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and extended-spectrum beta-lactamase (ESBL) producing E. coli were isolated on selective chromogenic microbiological media. The bactericidal effect of AgNPs foils obtained using non-toxic chemical compounds against E. coli, ESBL, S. aureus and MRSA isolated from oral cavities of selected animals was confirmed in this study. No statistically significant differences were observed between the foils obtained with different reducing agents. Therefore, all types of examined foils proved to be effective against the isolated bacteria.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Biodegradable Silver Nanoparticle Foils Based on Various Strains of Pathogenic Bacteria Isolated from the Oral Cavity of Cats, Dogs and Horses

Rutkowski

Krzemińska-Fiedorowicz

Khachatryan

et al. 2022

Materials

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“…It has been approved by the US Food and Drug Administration (FDA) for human use in certain biomedical applications [6]. As a polysaccharide hydrogel, it finds various applications in industry, for example, in biodegradable plastic packaging materials [7], medicine and biotechnology [8]. It is non-toxic, biodegradable, biocompatible and has a far lower cost than many other biopolymers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver and Gold Nanoparticles in Sodium Alginate Matrix Enriched with Graphene Oxide and Investigation of Properties of the Obtained Thin Films

et al. 2021

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Polymer nanocomposites containing nanometals became a subject of interest due to their bactericidal properties. Different polysaccharides have been used as matrices for nanosilver and nanogold synthesis. In this study, we present a novel, environmentally friendly method for the preparation of sodium alginate/nanosilver/graphene oxide (GOX) and sodium alginate/nanogold/graphene oxide GOX nanocomposites and their characteristics. The formation of approximately 10–20 nm ball-shaped Ag and Au nanoparticles was confirmed by UV–vis spectroscopy, scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectra. The incorporation of GOX sheets within the ALG matrix improved the thermal stability of the nanocomposites film, which was measured using the differential scanning calorimetry (DSC). We also estimated the molecular weights of polysaccharide chains of the matrix with the size exclusion chromatography coupled with multiangle laser light scattering and refractometric detectors (HPSEC-MALLS-RI). The composites were more prone to enzymatic hydrolysis. The strongest bacteriostatic activity was observed for the sample containing nanosilver.

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“…The rheological properties of the alginate hydrogel and its ease of gelation, biodegradability, and lack of toxicity make it suitable for a wide range of industrial applications (e.g., in the food industry, agriculture, cosmetics, packaging, and textiles). Its biomedical applications include dentistry, pharmaceuticals, wound healing, drug delivery, cell therapy, and as a bone graft substitute for spine fusion [ 4 , 47 ]. Fabrication of this hydrogel in the medical industry requires the use of high-purity sodium alginate to prevent immunogenicity [ 28 , 29 ].…”

Section: Materials and Methods For The Preparation And Characterizmentioning

confidence: 99%

A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

et al. 2021

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Sustaining the vital functions of cells outside the organism requires strictly defined parameters. In order to ensure their optimal growth and development, it is necessary to provide a range of nutrients and regulators. Hydrogels are excellent materials for 3D in vitro cell cultures. Their ability to retain large amounts of liquid, as well as their biocompatibility, soft structures, and mechanical properties similar to these of living tissues, provide appropriate microenvironments that mimic extracellular matrix functions. The wide range of natural and synthetic polymeric materials, as well as the simplicity of their physico-chemical modification, allow the mechanical properties to be adjusted for different requirements. Sodium alginate-based hydrogel is a frequently used material for cell culture. The lack of cell-interactive properties makes this polysaccharide the most often applied in combination with other materials, including gelatin. The combination of both materials increases their biological activity and improves their material properties, making this combination a frequently used material in 3D printing technology. The use of hydrogels as inks in 3D printing allows the accurate manufacturing of scaffolds with complex shapes and geometries. The aim of this paper is to provide an overview of the materials used for 3D cell cultures, which are mainly alginate–gelatin hydrogels, including their properties and potential applications.

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Alginate: Pharmaceutical and Medical Applications

Cited by 28 publications

References 264 publications

Antibacterial Properties of Biodegradable Silver Nanoparticle Foils Based on Various Strains of Pathogenic Bacteria Isolated from the Oral Cavity of Cats, Dogs and Horses

Antibacterial Properties of Biodegradable Silver Nanoparticle Foils Based on Various Strains of Pathogenic Bacteria Isolated from the Oral Cavity of Cats, Dogs and Horses

Synthesis of Silver and Gold Nanoparticles in Sodium Alginate Matrix Enriched with Graphene Oxide and Investigation of Properties of the Obtained Thin Films

A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

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