Alginate@TiO2 hybrid microcapsules with high in vivo biocompatibility and stability for cell therapy

Leroux, Grégory; Neumann, Myriam; Meunier, Christophe; Voisin, Virginie; Habsch, Isabelle; Caron, Nathalie; Michiels, Carine; Wang, Li; Su, Bao‐Lian

doi:10.1016/j.colsurfb.2021.111770

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…Furthermore, nano‐SiO 2 is directly involved in the hydration, which can change the form of hydration products. Meanwhile, it is noteworthy that the surface energy is another important factor affecting the contact angle: The higher the surface energy is, the better the hydrophilicity is 43,44 . In this respect, nano‐TiO 2 and nano‐SiO 2 co‐doping could have led to the emergence of more surface hydroxyl groups, thus increasing the surface energy of the composite.…”

Section: Resultsmentioning

confidence: 99%

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

Yang

et al. 2023

Asia-Pacific J Chem Eng

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Cement is an important way to digest industrial waste. Semi-dry gas desulfurized ash (SGDA) and granulated blast furnace slag (GBFS) as solid waste both have pozzolanic activity as well as small particle size and continuous particle size distribution, which allow their use as cement mixtures. In the present work, a cement matrix with 60% Portland cement, 20% SGDA, and 20% GBFS, including 3% nano-TiO 2 and 2% nano-SiO 2 as dopants, was produced via cement slurry mixing process. The obtained matrix was found to have the better 3-and 28-day age compressive strength (by 104% and 116%, respectively) as compared with the pure Portland cement; the mortar compressive strength is

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Section: Resultsmentioning

confidence: 99%

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

Yang

et al. 2023

Asia-Pacific J Chem Eng

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“…Such a microcapsule had a mesoporous structure, which is a key parameter allowing the diffusion of nutrients and metabolites. Subsequently, modification of the developed capsule with silicon dioxide made it possible to study the in vivo biocompatibility and stability of alginate/TiO 2 hybrid microcapsules and immune isolation of captured HepG2 cells to assess their potential for cell therapy [ 85 ].…”

Section: Classification Of Hybrid Materials According To the Precurso...mentioning

confidence: 99%

“…With versatile and customizable structures, mesoporous materials based on silica [ 70 , 85 ], titanium [ 84 ], or zinc [ 113 ] are capable of loading various molecules, including pharmaceuticals, therapeutic peptides, proteins, and genes. Mesoporous silicate nanomaterials have been used as a drug delivery system for various kinds of medications with different hydrophobic or hydrophilic properties, molecular weights, and biomedical effects [ 114 ].…”

Section: Classification Of Hybrid Materials According To the Applicat...mentioning

confidence: 99%

“…These medications include commonly used agents such as ibuprofen, doxorubicin, camptothecin, cisplatin, and alendronate. Peptide and protein preparations have been developed as effective therapeutic agents for many medical applications [ 84 ], including cancer therapy [ 113 ], vaccination and regenerative medicine [ 85 ]. Mesoporous silicates can protect biomolecules from premature degradation due to their porous structure.…”

Section: Classification Of Hybrid Materials According To the Applicat...mentioning

confidence: 99%

“…However, proteins are difficult to deliver, in part because of their inherently high molecular weight and fragile structure that must be maintained to retain activity [ 11 ]. Nevertheless, interest in delivery systems based on silicon dioxide or titanium dioxide [ 84 , 85 ] for the oral delivery of drugs, biomolecules, or cells is continuously growing. Active substance carriers can be synthesized in two ways: by encapsulating the biomaterial in presynthesized silica or by encapsulating and forming silica in one step ( Figure 14 ).…”

Section: Classification Of Hybrid Materials According To the Applicat...mentioning

confidence: 99%

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Preparation of Hybrid Sol-Gel Materials Based on Living Cells of Microorganisms and Their Application in Nanotechnology

et al. 2022

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Microorganism-cell-based biohybrid materials have attracted considerable attention over the last several decades. They are applied in a broad spectrum of areas, such as nanotechnologies, environmental biotechnology, biomedicine, synthetic chemistry, and bioelectronics. Sol-gel technology allows us to obtain a wide range of high-purity materials from nanopowders to thin-film coatings with high efficiency and low cost, which makes it one of the preferred techniques for creating organic-inorganic matrices for biocomponent immobilization. This review focuses on the synthesis and application of hybrid sol-gel materials obtained by encapsulation of microorganism cells in an inorganic matrix based on silicon, aluminum, and transition metals. The type of immobilized cells, precursors used, types of nanomaterials obtained, and their practical applications were analyzed in detail. In addition, techniques for increasing the microorganism effective time of functioning and the possibility of using sol-gel hybrid materials in catalysis are discussed.

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Synthesis of Urchin‐Like Au@TiO₂ Nano‐Carriers as a Drug‐Loading System Toward Cancer Treatment

Anh Nguyen,

Thi Le,

et al. 2024

ChemPlusChem

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In recent years, improving the pharmaceutical properties of drug delivery for anti‐cancer treatment has become increasingly important. This is necessary to address challenges related to absorption, distribution, and stability. One potential approach solution is to attach the drug to a carrier system, such as functional noble nanomaterials, in order to improve the control of drug release and stability. Core‐satellite nanoparticles (CSN) with an anisotropic morphology have enormous potential for targeted drug delivery and cancer treatment because of their large surface area, exceptional stability, and biocompatibility. We used a simple seed‐mediated approach to synthesize urchin‐like gold nanoparticles (ULGNPs) with a high aspect ratio and a dense network of 49 nm‐sized branches, using seed solution, silver nitrate, and ascorbic acid. The ULGNPs were synthesized without a surfactant and then encapsulated with thin layers of amorphous TiO2 (ULGNPs@TiO2), resulting in an average overall size of 136±15 nm with a 27.5 nm TiO2 layer. Doxorubicin (Dox) was chosen as a model drug to assess the distribution carrier ability of ULGNPs@TiO2 core‐satellite nanoparticles. The results showed 86.5% Dox loading and 72.3% release capacity at pH 5.

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Alginate@TiO2 hybrid microcapsules with high in vivo biocompatibility and stability for cell therapy

Cited by 9 publications

References 44 publications

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

Preparation of Hybrid Sol-Gel Materials Based on Living Cells of Microorganisms and Their Application in Nanotechnology

Synthesis of Urchin‐Like Au@TiO₂ Nano‐Carriers as a Drug‐Loading System Toward Cancer Treatment

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Alginate@TiO2 hybrid microcapsules with high in vivo biocompatibility and stability for cell therapy

Cited by 9 publications

References 44 publications

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO2 and nano‐SiO2

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO2 and nano‐SiO2

Preparation of Hybrid Sol-Gel Materials Based on Living Cells of Microorganisms and Their Application in Nanotechnology

Synthesis of Urchin‐Like Au@TiO2 Nano‐Carriers as a Drug‐Loading System Toward Cancer Treatment

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Product

Resources

About

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO₂ and nano‐SiO₂

Synthesis of Urchin‐Like Au@TiO₂ Nano‐Carriers as a Drug‐Loading System Toward Cancer Treatment