Alitretinoin‐induced curling of the hair

Trehan, Pooja; Wilson, N. J. E.

doi:10.1111/ajd.12370

Cited by 3 publications

(3 citation statements)

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“…In addition, two previous cases relating to a 70-year-old woman and a 44-year-old man describe curling of the hair in association with alitretinoin [ 6 , 12 ]. The latency in these cases is 3 and 4 months after the start of alitretinoin.…”

Section: Discussionmentioning

confidence: 99%

“…The latency in these cases is 3 and 4 months after the start of alitretinoin. The 70-year-old woman withdrew alitretinoin, but 1 year after onset of the event the hair had not straightened [ 12 ]. From the case report of the 44-year-old man, it is unknown whether the hair had straightened.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in hair texture, such as curling or brittleness of the hair, are not described in the Summary of Product Characteristics (SmPC) for this drug [ 1 , 2 ], but are mentioned in SmPCs of other systemic retinoids, such as isotretinoin and acitretin [ 3 , 4 ]. A few cases have also been reported in the literature in which retinoids such as isotretinoin, acitretin and etretinate have been attributed to changes in hair texture or color [ 9 , 12 , 13 , 15 – 21 ]. Changes in hair texture may potentially affect compliance, thereby resulting in less efficacy of therapy.…”

Section: Introductionmentioning

confidence: 99%

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Curling of Hair in Two Female Patients Taking Alitretinoin

Alting

Hunsel

2018

Drug Saf - Case Rep

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Two female patients aged 45 and 51 years experienced curling of hair during treatment with alitretinoin (Toctino®). For one patient, the indication for use was severe chronic hand eczema, but for the second patient the indication was not reported. After 5 and 9 months, respectively, the patients developed hair texture changes and their straight hair began to curl. The dose of alitretinoin was reduced in both cases, but the patients’ hair had not straightened at the time of reporting (9 months and 2 years after onset of the event). Based on the described reports received by the Netherlands Pharmacovigilance Centre Lareb, the case reports in the literature, and the possible mechanisms, we suggest a causal relationship between curling of the hair and the use of alitretinoin. Using the World Health Organization Uppsala Monitoring Centre (WHO-UMC) system for standardized case causality assessment, the association in our cases can be assessed as likely.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%