Alkaloids

Wiart, Christophe

doi:10.1016/b978-0-12-398371-8.00001-5

Cited by 13 publications

(4 citation statements)

References 310 publications

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“…This plant belongs to the category of vines with perennial woody roots and has heart-shaped leaves with unisexual flowers. The stems can grow from 0.6 to 0.9 m. The fruits, which grow in fleshy spikes 2.4–3.2 cm long and 5 mm thick, are blunt, oblong, and blackish green [ 71 , 72 , 73 ].…”

Section: Distribution Botanical Traditional Use and Pharmacological P...mentioning

confidence: 99%

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

et al. 2022

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Antioxidants are compounds that are able to inhibit the negative effects that come from free radicals. The phenomenon of imbalanced antioxidant production and the accumulation of free radicals in cells and tissues can cause oxidative stress. Excessive free radicals that enter the body cannot be warded off by endogenous antioxidant compounds so that the required antioxidant compounds can come from the outside, which helps in the performance of endogenous antioxidants. Antioxidants that come from outside consist of synthetic and natural antioxidants; however, synthetic antioxidants are not an option because they have toxic and carcinogenic effects. Therefore, the use of natural ingredients is an alternative method that is needed to create a new natural antioxidant compound. Piper species are being considered as possible medicinal plants for the development of new sources of antioxidants. Several studies have been carried out starting from the extract levels, fractions, and compounds of the Piper species, which showed good antioxidant activity. Currently, some of these plants are being used as ingredients in traditional medicines to treat allergies, toothaches, and coughs. This review examines the distribution, botanical data, pharmacology, especially antioxidant activity, and the compounds contained in five Piper species, namely Piper amalago L., Piper betle L., Piper hispidum Sw., Piper longum L., and Piper umbellatum L.

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Section: Distribution Botanical Traditional Use and Pharmacological P...mentioning

confidence: 99%

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

et al. 2022

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“…(Cynanchum paniculatum (Bunge) Kitag.) showed pronounced inhibitory activities in numerous cancer cell lines (Wiart, 2013). Although we were not able to find studies conducted with extracts of Vincetoxicum hirundinaria in this context, the activities reported for the PIAs seem to correlate with the use of the relevant RBH recipe, such as different inflammatory conditions or perhaps also tumours (Supplementary Material, Table S6).…”

Section: Preliminary In Vitro Screeningmentioning

confidence: 89%

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

Stehlin,

Albert,

Frei

et al. 2024

Preprint

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Ethnopharmacological relevance: Historical texts on materia medica can be an attractive source of ethnopharmacological information. In recent decades, various research groups have investigated corresponding resources from Europe and the Mediterranean region, pursuing different objectives. Regardless of the method used in such a work, the indexing of textual information and its conversion into data sets useful for further investigations represents a significant challenge. Aim of the study: First of all, this study aims to systematically catalogue pharmaco-botanical information in the Receptarium of Burkhard from Hallwyl (RBH) in order to identify candidate plants in a targeted manner. Secondly, the potential of RBH as a resource for pharmacological investigations will be assessed by means of a preliminary in vitro screening. Materials and methods: We developed a relational database for the systematic recording of the parameters composing the medical recipes contained in the historical text. Focusing on dermatological recipes, we explored the mentioned plants and their uses by drawing on specific literature. The botanical identities (candidate species) suggested in the literature for the historical plant names were rated based on their plausibility of being the correct attribution. The historical uses were interpreted by consulting medical-historical and modern clinical literature. For the subsequent in vitro screening, we selected candidate species used in recipes directed at the treatment of inflammatory or infectious skin disorders and wounds. Plants were collected in Switzerland and their hydroethanolic crude extracts tested for possible cytotoxic effects and for their potential to modulate the release of IL-6 and TNF in LPS-stimulated whole blood and PBMCs. Results: The historical text analysis points up the challenges associated with the assessment of historical plant names. Often two or more plant species are available as candidates for each of the 161 historical plant names counted in the 200 dermatological recipes in RBH. At the same time, the 56 medicinal uses mentioned in these recipes illustrate, that the details provided in the text about the skin problem in question enable conclusions to be drawn based on which the presumed underlying medical condition and its pharmacological basis can be narrowed down. On this basis, 11 candidate species were selected for in vitro screening, four of which were used in RBH in herbal simple recipes and seven in a herbal compound formulation. None of the extracts tested showed a noteworthy effect on cell viability except for the sample of Sanicula europaea. Extracts were tested at 50 μg/mL in the whole blood assay, where especially Vincetoxicum hirundinaria or Solanum nigrum showed inhibitory or stimulatory activities. In the PBMC assay, the root of Vincetoxicum hirundinaria revealed a distinct inhibitory effect on IL-6 release (IC50 of 3.6 μg/mL). Conclusions: Using the example of RBH, this study illustrates a possible ethnopharmacological path from unlocking the historical text and its subsequent analysis, through the selection and collection of plant candidates to their in vitro investigation. Fully documenting our approach to the analysis of historical texts, we hope to contribute to the discussion on solutions for the digital indexing of premodern information on the use of plants or other natural products.

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“…The extract of the plant Alangium lamarckii has been used by Indians to treat many human disorders [ 103 ]. In Thailand, it is useful in the treatment of asthma, coughs, hemorrhoids, diarrhea; and in India to treat leprosy, fever, or as an anthelmintic agent [ 104 , 105 ]. Pakrashi et al [ 106 , 107 ] isolated tetracyclic alkaloids from the seeds of A. lamarckii .…”

Section: Naturally Occurring Naphthyridine Derivativesmentioning

confidence: 99%

Biological Activity of Naturally Derived Naphthyridines

2021

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Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

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Alkaloids

Cited by 13 publications

References 310 publications

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

Biological Activity of Naturally Derived Naphthyridines

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Alkaloids

Cited by 13 publications

References 310 publications

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

Biological Activity of Naturally Derived Naphthyridines

Contact Info

Product

Resources

About

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening