Alkaloids and phenolics of three Merendera species

Husek, A.; Sütlüpınar, N.; Potěšilová, H.; Dvorácková, S; Hanuš, V.; Sedmera, Petr; Maloň, Petr; Šimánek, Vilı́m

doi:10.1016/0031-9422(89)80310-3

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Methyl 2‐hydroxybenzoate and the corresponding acid, but not the 4‐isomers, are becoming well established as plant stress signals countering pest attack10 through regulation of gene expression 11. 2‐Hydroxy‐6‐methoxybenzoic acid and derivatives have only occasionally been reported as plant chemicals 12–14. However, after completion of this work, a recent report15 was found confirming the presence of methyl 2‐hydroxybenzoate and methyl 2‐hydroxy‐6‐methoxybenzoate in root bark of S. longepedunculata , but not the benzyl ester.…”

Section: Discussionmentioning

confidence: 72%

Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers

Jayasekara¹,

Stevenson²,

Belmain³

et al. 2002

J. Mass Spectrom.

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Securidaca longepedunculata Fers (Polygalaceae) is commonly used as a medicine in many parts of Africa and shows promise for protecting stored grain against insect pests. Analysis of a methanol extract of the root bark by gas chromatography linked to mass spectrometry (GC/MS) showed a major component accounting for over 90% of the volatile material. This was identified as methyl 2-hydroxybenzoate (methyl salicylate) by comparison of the GC retention times and mass spectrum with those of synthetic standards. This conflicts with an earlier report that the major component is methyl 4-hydroxybenzoate. Two minor components had mass spectra characteristic of 2-hydroxybenzoate esters and were identified as methyl 2-hydroxy-6-methoxybenzoate and its benzyl analogue, again conflicting with an earlier report.

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Section: Discussionmentioning

confidence: 72%

Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers

Jayasekara¹,

Stevenson²,

Belmain³

et al. 2002

J. Mass Spectrom.

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“…Further hydroxylation, oxidation, reduction, and methylation steps then result in the substitution patterns for 4 and 5 , herein referred to as 8-oxohomoaporphine derivatives. Interestingly, so far, homoaporphines have only been isolated from plants in the family Liliaceae. , On the other hand, compound 3 displayed an unusual oxahomoaporphine skeleton bearing an oxepane moiety. It is plausible that the biosynthetic formation of 3 may occur via hydroxylation of the α′-position of ( S )-benzylisoquinoline derivatives (e.g., N , O -dimethylcoclaurine) followed by isomerization as a key step to access the oxepane motif (Scheme ).…”

Section: Results and Discussionmentioning

confidence: 99%

Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis

et al. 2019

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In addition to seven known alkaloids (2, 6–11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3–5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensis alkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated.

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“…The higher content of colchicine in Gloriosa than in Colchicum makes it a commercially viable source of this medicine [9,10]. Several techniques have been developed to extract colchicine, and among these ‘soxhlet and solid–liquid extraction’ are the most commonly used [11,12]. Extraction of colchicine from C. autumnale using methanol [6], and from Gloriosa seeds by methanol [13] and ethanol [14] has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Colchicine: Isolation, LC–MS QTof Screening, and Anticancer Activity Study of Gloriosa superba Seeds

et al. 2019

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Colchicine was extracted from Gloriosa superba seeds using the Super Critical Fluid (CO2) Extraction (SCFE) technology. The seeds were purified upto 99.82% using column chromatography. Colchicine affinity was further investigated for anticancer activity in six human cancer cell lines, i.e., A549, MCF-7, MDA-MB231, PANC-1, HCT116, and SiHa. Purified colchicine showed the least cell cytotoxicity and antiproliferation and caused no G2/M arrest at clinically acceptable concentrations. Mitotic arrest was observed in only A549 and MDA-MB231 cell lines at 60nM concentration. Our finding indicated the possible use of colchicine at a clinically acceptable dose and provided insight into the science behind microtubule destabilization. However, more studies need to be conducted beforethese findings could be established.

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Alkaloids and phenolics of three Merendera species

Cited by 9 publications

References 6 publications

Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers

Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers

Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis

Colchicine: Isolation, LC–MS QTof Screening, and Anticancer Activity Study of Gloriosa superba Seeds

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