Alkaloids and Selected Topics in Their Thermochemistry

Ponikvar‐Svet, Maja; Zeiger, Diana N.; Liebman, Joel F.

doi:10.3390/molecules26216715

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…Alkaloids are usually colorless, bitter-tasting nitrogen oxides that are found in the plant kingdom, especially in seeds [72]. Due to their wide range of pharmacological properties, including analgesic, anti-inflammatory, anti-tumor, antioxidant, and antibacterial effects, alkaloids are valuable sources for drug development [73].…”

Section: Alkaloidsmentioning

confidence: 99%

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

et al. 2023

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and its incidence continues to increase each year. Yet, there is still no definitive drug that can stop its development. This review focuses mainly on lipotoxicity, oxidative stress, inflammation, and intestinal flora dysbiosis to understand NAFLD’s pathogenesis. In this review, we used NCBI’s PubMed database for retrieval, integrating in vivo and in vitro experiments to reveal the therapeutic effects of natural compounds on NAFLD. We also reviewed the mechanisms by which the results of these experiments suggest that these compounds can protect the liver from damage by modulating inflammation, reducing oxidative stress, decreasing insulin resistance and lipid accumulation in the liver, and interacting with the intestinal microflora. The natural compounds discussed in these papers target a variety of pathways, such as the AMPK pathway and the TGF-β pathway, and have significant therapeutic effects. This review aims to provide new possible therapeutic lead compounds and references for the development of novel medications and the clinical treatment of NAFLD. It offers fresh perspectives on the development of natural compounds in preventing and treating NAFLD.

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Section: Alkaloidsmentioning

confidence: 99%

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

et al. 2023

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“…Os alcaloides são compostos, que contém nitrogênio em sua estrutura, principalmente heterocíclicos, esse nitrogênio se encontra em um estado de oxidação negativo e com um limite de distribuição entre os seres vivos [12][13][14]. 19 Foi utilizado acetato de etila como solvente de extração, para identificação dos inibidores da proteína tirosina fosfatase 1B (PTP1B).…”

Section: Composição Fitoquímicaunclassified

Potencial farmacológico da canela-de-velho (Miconia albicans): Uma revisão integrativa

Silva Lopes,

Fernandes Queiroga Moraes,

De Cabral Sobreira

et al. 2023

Rev. Colomb. Cienc. Quím. Farm.

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Objetivos: o presente estudo teve como finalidade realizar uma revisão da literaturasobre a planta Miconia albicans e seu potencial terapêutico. Metodologia: trata-se deuma revisão do tipo integrativa sem limitação de tempo nas bases de dados científicosPubMed, ScienceDirect, Google Acadêmico e na BVS. Resultados: dos 113 artigosrecuperados nas bases de dados, 31 foram selecionados para compor os resultados,em que foram identificados os compostos fenólicos e os terpenos como as classes demetabólitos secundários, mais prevalentes. Se evidenciou condições relacionadas adores articulares como artrite, artrose e dor na coluna/costas, como os problemasmais relacionados ao seu uso. As atividades anti-inflamatória e antimicrobianaforam as mais frequentes entre os estudos, mas também foram obtidos resultadospositivos para as atividades antioxidante, ansiolítica, anticonvulsivante, analgésica,antidiabética e propriedades antiofídicas. Foram atribuídos também possíveis mecanismosde ação, o antioxidante ligado ao sequestro de radicais livres, anti-inflamatórioa inibição de enzimas da cascata do ácido araquidônico, bloqueio do aumentodos níveis de citocinas inflamatórias, diminuição dos níveis de adipocitocinas e dosreceptores solúveis do TNF-α, antidiabético inibição da proteína tirosina fosfatase 1B e ansiolítico relação com os receptores gabaérgicos. Conclusão: à vista disso, aliteratura aponta para a necessidade de mais estudos, para uma confirmação confiável,em que se possa garantir um uso seguro da planta e a abertura de um leque denovas opções de terapias medicamentosas para a população.

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“…Alkaloids are usually colorless and bitter basic nitrogen compounds (mainly heterocyclic), which mainly exist in the plant kingdom and usually have physiological activities [ 75 ]. Alkaloids exhibit different biological activities, such as anti-tumor, anti-inflammatory, antibacterial, and antiviral [ 76 ].…”

Section: Natural Compoundsmentioning

confidence: 99%

Molecular Mechanistic Pathways Targeted by Natural Compounds in the Prevention and Treatment of Diabetic Kidney Disease

et al. 2022

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Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and its prevalence is still growing rapidly. However, the efficient therapies for this kidney disease are still limited. The pathogenesis of DKD involves glucotoxicity, lipotoxicity, inflammation, oxidative stress, and renal fibrosis. Glucotoxicity and lipotoxicity can cause oxidative stress, which can lead to inflammation and aggravate renal fibrosis. In this review, we have focused on in vitro and in vivo experiments to investigate the mechanistic pathways by which natural compounds exert their effects against the progression of DKD. The accumulated and collected data revealed that some natural compounds could regulate inflammation, oxidative stress, renal fibrosis, and activate autophagy, thereby protecting the kidney. The main pathways targeted by these reviewed compounds include the Nrf2 signaling pathway, NF-κB signaling pathway, TGF-β signaling pathway, NLRP3 inflammasome, autophagy, glycolipid metabolism and ER stress. This review presented an updated overview of the potential benefits of these natural compounds for the prevention and treatment of DKD progression, aimed to provide new potential therapeutic lead compounds and references for the innovative drug development and clinical treatment of DKD.

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Alkaloids and Selected Topics in Their Thermochemistry

Cited by 6 publications

References 39 publications

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

Potencial farmacológico da canela-de-velho (Miconia albicans): Uma revisão integrativa

Molecular Mechanistic Pathways Targeted by Natural Compounds in the Prevention and Treatment of Diabetic Kidney Disease

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