Alkaloids from<i>Piper nigrum</i>Exhibit Antiinflammatory Activity via Activating the Nrf2/HO­1 Pathway

Ngo, Quynh-Mai Thi; Tran, Phuong Thao; Tran, Manh Hung; Kim, Jeong Ah.; Rho, Seong Soo; Lim, Chi-Hwan; Kim, Jin-Cheol; Woo, Mi Hee; Choi, Jae Sui; Lee, Jeong‐Hyung; Min, Byung Sun

doi:10.1002/ptr.5780

Cited by 38 publications

(21 citation statements)

References 39 publications

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“…The radical scavenging and antioxidant activities of these compounds have been extensively reported [35][36][37][38]. Moreover, accumulating evidences suggested that these dietary phytochemicals potently strengthen the antioxidative potential through the modulation of the Nrf2/antioxidant responsive element (ARE) signaling pathway [39][40][41][42]. Nrf2 is a master regulator of the antioxidant response.…”

Section: Discussionmentioning

confidence: 99%

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

et al. 2019

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Thai traditional herbal formula ‘’Kleeb Bua Daeng (KBD)’’consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities in both frontal cortex and hippocampus. The effects of KBD were similar to those caused by oral administration of vitamin E. HPLC analysis of the KBD extract revealed the presence of piperine, madecassoside, asiaticoside, luteolin-7-O-glucoside, rutin, kaempferol-3-glucoside, quercetin, kaempferol and ferulic acid as major constituents.

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Section: Discussionmentioning

confidence: 99%

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

et al. 2019

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“…Additionally, reports indicate pro-apoptotic and anti-proliferative activities of HO-1 in prostate, breast and oral cancer. Although exact process of the act is unknown [28,29].…”

Section: Discussionmentioning

confidence: 99%

Anti-Cancer Activity of Piperine Against Colon Carcinogenesis Via Modulation of NF-κB/Nrf-2/Keap1/HO-1 Signalling Pathways

Rehman¹,

Rashid²,

Arafah³

et al. 2020

Preprint

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Background: Colon cancer is the most common cancer in men and women globally, killing millions of people annually. Though widespread development has been made in the management of colorectal cancer, still there is an urgency to find novel targets for effective treatment of these patients. Piperine is an alkaloid found in black pepper having anticancer, anti-oxidant and anti-inflammatory activities. Nuclear factor-erythroid 2–kelch-like ECH-associated protein 1(Nrf-2/Keap1)/ Heme-oxygenase1 (HO-1) signaling pathway plays a vital part in shielding cells from the injury of intracellular oxidative stress and inflammation. A potential cross-talk between Nrf-2 and NF-κB pathways is recognized during cancerous growth and expansion. We studied this pathway extensively in the present study to discover novel targets in prevention of chemically induced colon cancer with piperine.Results: We found that NF-κB inhibition occurs by the activation of Nrf-2 blocks downstream inflammatory mediators/cytokines (TNF-α, IL-6, IL-1β, Cox-2, PGE2, iNOS, NO, MPO) and triggers antioxidant response machinery (HO-1, NQO-1 GSH, GR, GPx, CAT, SOD), scavenges ROS, decreases lipid peroxidation. Histological findings further validated our defensive effects of piperine on colon carcinogenesis. Piperine down-regulates CEA, MDF and ACF, markers of precancerous lesions in colon.Conclusion: Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting NF-κB/Nrf-2/Keap1/HO-1 pathway as a progressive strategy in preclusion and effective treatment of colorectal cancer.

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“…Piper species have been shown to be effective as anti-inflammatory reagent [39,40]. In particular, antiinflammatory activity of piperine has been reported in rats, with several experimental models, such as carrageenan-induced rat paw edema, cotton pellet granuloma and cotton-oil-induced granuloma pouch [17], but the mechanism of action remains unknown in t-BHP-induced rat liver cells.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of piperine on t-BHP-induced in Ac2F cells

Chung¹,

Jung²,

Kim³

et al. 2019

SDRP-JFST

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Background: In this study, to investigate whether piperine, an alkaloid from Pipper longum, could potentially exerts its effect for the suppression of inflammation and oxidative stress, we examined the modulatory effects of piperine in tert-butylhydroperoxide (t-BHP)-induced Ac2F rat liver cells. Methods: Anti-inflammatory mechanism of piperine in Ac2F cells were examined by performing western blotting. Results: The piperine exhibited remarkable reduction of intracellular reactive species (RS) levels in t-BHPand SIN-1-induced Ac2F cells. In addition, piperine inhibited t-BHP-induced activation of nuclear factor kappa B (NF-κB) by suppressing the degradation of inhibitor-κB proteins (IκBα) and translocation of p65 from the cytosol to the nucleus, further indicating piperine's inhibitory effects on nitric oxide synthase (iNOS), cyclooxyganse-2 (COX-2) expressions. As a consequence, piperine modulated through inhibition of ERK, JNK, and p38 MAPKs signal transduction pathway in cells. Moreover, piperine pretreatment also regulated the protein expression of antioxidant enzymes such as manganese-dependent superoxide dismutase (MnSOD) and catalase. Conclusion: These results indicated that piperine, a major component of black pepper might be a potential antiinflammatory agent by modulating RS-induced NF-κB activation through the MAPKs signaling pathway and possess the anti-oxidative property. Therefore piperine can be considered as a useful therapeutic and preventive approach for the treatment of inflammation and oxidative stress-related diseases.

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Alkaloids fromPiper nigrumExhibit Antiinflammatory Activity via Activating the Nrf2/HO1 Pathway

Cited by 38 publications

References 39 publications

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

Anti-Cancer Activity of Piperine Against Colon Carcinogenesis Via Modulation of NF-κB/Nrf-2/Keap1/HO-1 Signalling Pathways

Anti-inflammatory and antioxidant activities of piperine on t-BHP-induced in Ac2F cells

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Alkaloids fromPiper nigrumExhibit Antiinflammatory Activity via Activating the Nrf2/HO­1 Pathway

Cited by 38 publications

References 39 publications

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

Anti-Cancer Activity of Piperine Against Colon Carcinogenesis Via Modulation of NF-κB/Nrf-2/Keap1/HO-1 Signalling Pathways

Anti-inflammatory and antioxidant activities of piperine on t-BHP-induced in Ac2F cells

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Alkaloids fromPiper nigrumExhibit Antiinflammatory Activity via Activating the Nrf2/HO1 Pathway