Alkaloids in food: a review of toxicity, analytical methods, occurrence and risk assessments

Akinboye, Adebayo J.; Kim, Kiyun; Choi, Seyun; Yang, Inho; Lee, Joon‐Goo

doi:10.1007/s10068-023-01295-0

Cited by 11 publications

(2 citation statements)

References 184 publications

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“…However, there are some limitations in the clinical use of alkaloids. The major challenge is the toxicity as some alkaloids may produce liver, kidney and neuron damage [74]. Wellconducted toxicity studies, focusing on the toxicity level and precise mechanism of action of alkaloids, are needed to overcome this limitation.…”

Section: Discussionmentioning

confidence: 99%

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Di Dalmazi,

Giuliani,

Bucci

et al. 2024

IJMS

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Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common diseases in the general population, with higher incidence in women. Chronic inflammation and autoimmunity play a pivotal role in carcinogenesis. Some studies, indeed, have pointed out the presence of AITD as a risk factor for TC, although this issue remains controversial. Prevention of autoimmune disease and cancer is the ultimate goal for clinicians and scientists, but it is not always feasible. Thus, new treatments, that overcome the current barriers to prevention and treatment of TC and AITD are needed. Alkaloids are secondary plant metabolites endowed with several biological activities including anticancer and immunomodulatory properties. In this perspective, alkaloids may represent a promising source of prophylactic and therapeutic agents for TC and AITD. This review encompasses the current published literature on alkaloids effects on TC and AITD, with a specific focus on the pathways involved in TC and AITD development and progression.

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Section: Discussionmentioning

confidence: 99%

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Di Dalmazi,

Giuliani,

Bucci

et al. 2024

IJMS

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“…In addition, plants containing ALs are a common component of the human diet, present in both food and beverages [ 10 ]. Some well-known examples of ALs found in the human diet include caffeine from coffee seeds, theobromine from cocoa seeds, theophylline from tea leaves, tomatine from tomatoes, and solanine from potatoes [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Electrochemical Studies of Selected Alkaloid N-Oxides

Dushna,

Dubenska,

Gawor

et al. 2024

Molecules

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In this work, we synthesized and confirmed the structure of several alkaloid N-oxides using mass spectrometry and Fourier-transform infrared spectroscopy. We also investigated their reduction mechanisms using voltammetry. For the first time, we obtained alkaloid N-oxides using an oxidation reaction with potassium peroxymonosulfate as an oxidant. The structure was established based on the obtained fragmentation mass spectra recorded by LC-Q-ToF-MS. In the FT-IR spectra of the alkaloid N-oxides, characteristic signals of N-O group vibrations were recorded (bands in the range of 928 cm⁻1 to 971 cm⁻1), confirming the presence of this functional group. Electrochemical reduction studies demonstrated the reduction of alkaloid N-oxides at mercury-based electrodes back to the original form of the alkaloid. For the first time, the products of the electrochemical reduction of alkaloid N-oxides were detected by mass spectrometry. The findings provide insights into the structural characteristics and reduction behaviors of alkaloid N-oxides, offering implications for pharmacological and biochemical applications. This research contributes to a better understanding of alkaloid metabolism and degradation processes, with potential implications for drug development and environmental science.

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Assessment of underutilized Mangifera indica peels for nutritional, phytochemical and techno-functional attributes as well as its microstructural and thermal characterization

Kaur,

Panesar,

Thakur

2024

J Food Sci Technol

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Alkaloids in food: a review of toxicity, analytical methods, occurrence and risk assessments

Cited by 11 publications

References 184 publications

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Structural Characterization and Electrochemical Studies of Selected Alkaloid N-Oxides

Assessment of underutilized Mangifera indica peels for nutritional, phytochemical and techno-functional attributes as well as its microstructural and thermal characterization

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