Alkaloids of Peumus Boldus. Isolation of Laurotetanine and Laurolitsine

Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla

“…In Malaysia, apart from treating general ailments, the leaves are also used as a mosquito repellent due to their fragrant smell [1c].The main chemical constituents of these plants are isoquinoline alkaloids, which are clinically responsible for their pharmacological activities such as the well-known narcotic analgesics, morphine and codeine, apomorphine (a derivative of morphine) used in Parkinson's disease, the muscle relaxant papaverine, and the antimicrobial agents sanguinarine and berberine The present study examined Actinodaphne macrophylla (Blume) from Lauraceae family to determine its anti-malarial activity by focusing on isoquinoline alkaloids: cycleanine (1), 10demethylxylopinine (2), reticuline (3), laurotetanine (4), bicuculine (5), α-hydrastine (6), parfumine (7) (which could not be obtained as a pure compound) and anolobine (8) (Figure 1). These isolated compounds were elucidated by spectroscopic methods [3][4][5][6][7][8][9][10] and the seven pure alkaloids were used to study their in vitro activity against Plasmodium falciparum. Isoquinoline alkaloids from different plant families have been used widely for anti-malarial activity, such as protopine and coreximine form Corydalis crispa [11].…”

“…The present study examined Actinodaphne macrophylla (Blume) from Lauraceae family to determine its anti-malarial activity by focusing on isoquinoline alkaloids: cycleanine (1), 10demethylxylopinine (2), reticuline (3), laurotetanine (4), bicuculine (5), α-hydrastine (6), parfumine (7) (which could not be obtained as a pure compound) and anolobine (8) (Figure 1). These isolated compounds were elucidated by spectroscopic methods [3][4][5][6][7][8][9][10] and the seven pure alkaloids were used to study their in vitro activity against Plasmodium falciparum. Isoquinoline alkaloids from different plant families have been used widely for anti-malarial activity, such as protopine and coreximine form Corydalis crispa [11].…”

Glutinosine A: A New Morphinandienone Alkaloid from Litsea glutinosa

“…glutinosa is an evergreen medium-size tree, which is widely distributed in subtropical and tropical regions. This plant has been used as traditional medicine for treatment of many diseases [1,2]. Pharmacological investigations indicated that the leaves and barks of L. glutinosa possessed antibacterial, anti-inflammatory, anti-nociceptive, analgesic and anti-diabetic properties [3,4].…”

Recent Advances for the C–C and C–N Bond Formation in the Synthesis­ of 1-Phenethyl-tetrahydroisoquinoline, Aporphine, Homoaporphine­, and β-Carboline Alkaloids

“…Laurolitsine (31) was isolated from the leaves of Peumus boldus Molina in 0.001% 55 Based on the biosynthesis of aporphine alkaloids, Lee and co-workers 56 transformed laurolitsine (31) into a series of aporphine alkaloids 34-37. Beginning with N-protection and followed by O-methylation, the intermediate 33 was subjected to treatment with strong acid for an extended period (8 days) in order to produce pacordine (34), an alkaloid found in Popowia pisocarpa, an Annonaceous plant.…”