2021
DOI: 10.3390/molecules26092629
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Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Abstract: The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history. This genus’ particular bioactivity results from the enormous diversity of alkaloids it contains, making it a valuable study organism for many disciplines. Although Datura contains mostly tropane alkaloids (such as hyoscyamine and scopolamine), indole, beta-carboline, and pyrrolidine alkaloids have also been identified. The tools available to explore speciali… Show more

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Cited by 34 publications
(28 citation statements)
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References 150 publications
(413 reference statements)
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“…The largest total alkaloid of Parkia timoriana seeds as much as 48.90 mg/g was found in the methanol extract. Alkaloids are low molecular weight compounds and are generally alkaline due to the presence of a nitrogen atom in their heterocyclic ring (Nobahar et al 2021), so alkaloids range from polar to semi-polar compounds (Cinelli and Jones 2021). Methanol is a compound that has a molecular structure of CH 3 OH, is polar because it has a hydroxyl group (-OH), and is non-polar because it has a methyl group (-CH 3 ) (Ramdani et al 2017).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The largest total alkaloid of Parkia timoriana seeds as much as 48.90 mg/g was found in the methanol extract. Alkaloids are low molecular weight compounds and are generally alkaline due to the presence of a nitrogen atom in their heterocyclic ring (Nobahar et al 2021), so alkaloids range from polar to semi-polar compounds (Cinelli and Jones 2021). Methanol is a compound that has a molecular structure of CH 3 OH, is polar because it has a hydroxyl group (-OH), and is non-polar because it has a methyl group (-CH 3 ) (Ramdani et al 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Alkaloids are plant-friendly chemicals that act as a deterrent to predators and parasites. Alkaloids have been noted to possess antimicrobial, antihypertensive, antifungal, anti-inflammatory, anti-fibrogenic effects as well as anti-diarrheal effects which may be related to their action on the small intestine (Cinelli and Jones 2021).…”
Section: Discussionmentioning
confidence: 99%
“…After the seeds are used for oil extraction, sunflower receptacles have largely been discarded [ 4 , 5 , 6 ], which not only wastes resources, but also pollutes the environment. Sunflower receptacles contains many active compounds, including flavonoids [ 7 , 8 ], alkaloids [ 9 , 10 ], and chlorogenic acid [ 11 , 12 ]. However, there are few existing studies on the essential oil of sunflower receptacles.…”
Section: Introductionmentioning
confidence: 99%
“…Atropine is used to treat diseases related to the pupil, hay fever, colds, intestinal spasms, and as an antidote to toxic gases and insecticides. However, the disadvantages of this drug in higher doses far outweigh the bene ts and signi cantly expand the anticholinergic effect and psychiatric patients [4], [5].…”
Section: Introductionmentioning
confidence: 99%