Alkaloids of the Lauraceae

Teles, Maria Madalena Rocha Silva; Pinheiro, Anderson Angel Vieira; Dias, Celidarque da Silva; Tavares, Josean Fechine; Barbosa-Filho, José Maria; Cunha, Emídio Vasconcelos Leitão da

doi:10.1016/bs.alkal.2018.11.002

Cited by 22 publications

(18 citation statements)

References 192 publications

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“…8). 23,37,44 The identication of phenolic compounds and alkaloids within the sample corroborates the clustering pattern observed in the chemometric analyses. Previous studies with other botanic matrices evidences that the optimal extraction conditions for phenolic compounds are related to the use of moderate temperatures (up to 37 C) and aqueous solvent concentrations varying from 50 to 70%.…”

Section: Phytochemical Screening Of Ocotea Guianensissupporting

confidence: 74%

“…The formation of 3 clusters even by the usage of a low resolution method, such as TLC, to evaluate the chemical prole highlights the importance of method development for untargeted metabolomics, even in wellknown botanic groups such as Lauraceae. 23,37 Multivariate analysis emphasizes the signicant inuence of the evaluated operational parameters on the chemical prole composition and quality.…”

Section: Effects In the Extraction Yieldmentioning

confidence: 99%

“…O. guianensis is the species-type used to dene the Ocotea genus, however few publications describing its chemical composition are available, and most of these are focused on its essential oil, 23,24,37,42,43 even though it was the rst species taxonomically described for the genus. In order to provide a preliminary characterization of the phytochemicals present in O. guianensis a MS 2 data-dependent analysis of the sample was performed with 1A-2A-3C-4A (which represents the optimized extraction conditions) in an UHPLC-HRMN.…”

Section: Phytochemical Screening Of Ocotea Guianensismentioning

confidence: 99%

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Phytochemistry by design: a case study of the chemical composition of Ocotea guianensis optimized extracts focused on untargeted metabolomics analysis

et al. 2020

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Section: Phytochemical Screening Of Ocotea Guianensissupporting

confidence: 74%

Section: Effects In the Extraction Yieldmentioning

confidence: 99%

Section: Phytochemical Screening Of Ocotea Guianensismentioning

confidence: 99%

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Phytochemistry by design: a case study of the chemical composition of Ocotea guianensis optimized extracts focused on untargeted metabolomics analysis

et al. 2020

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“…Their diversity is due to the different substituents on the aromatic rings. They are biosynthetically obtained from benzyltetrahydroisoquinoline units through phenolic oxidative coupling [4]. The representative of this structural type is alkaloid berbamine from Berberis vulgaris [5].…”

Section: Introductionmentioning

confidence: 99%

Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells

et al. 2020

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Bersavine is the new bisbenzylisoquinoline alkaloid isolated from the Berberis vulgaris L. (Berberidaceae) plant. The results of cytotoxicity screening 48 h post-treatment showed that bersavine considerably inhibits the proliferation and viability of leukemic (Jurkat, MOLT-4), colon (HT-29), cervix (HeLa) and breast (MCF-7) cancer cells with IC50 values ranging from 8.1 to 11 µM. The viability and proliferation of leukemic Jurkat and MOLT-4 cells were decreased after bersavine treatment in a time- and dose-dependent manner. Bersavine manifested concentration-dependent antiproliferative activity in human lung, breast, ovarian and hepatocellular carcinoma cell lines using a xCELLigence assay. Significantly higher percentages of MOLT-4 cells exposed to bersavine at 20 µM for 24 h were arrested in the G1 phase of the cell cycle using the flow cytometry method. The higher percentage of apoptotic cells was measured after 24 h of bersavine treatment. The upregulation of p53 phosphorylated on Ser392 was detected during the progression of MOLT-4 cell apoptosis. Mechanistically, bersavine-induced apoptosis is an effect of increased activity of caspases, while reduced proliferation seems dependent on increased Chk1 Ser345 phosphorylation and decreased Rb Ser807/811 phosphorylation in human leukemic cells.

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“…Bisbenzylisoquinoline compounds have recently attracted attention as therapeutics due to their innate chemical diversity and wide-ranging pharmacological effects, making them powerful scaffolds for drug optimization (Tian and Zheng, 2017;Teles et al, 2019). Berbamine, a plant alkaloid derived from Berberidaceae (barberry plants), has its pharmacological origins in traditional Chinese medicine as an anti-inflammatory agent.…”

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confidence: 99%

Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

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Namjoshi

et al. 2020

Front. Cell. Neurosci.

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Alkaloids of the Lauraceae

Cited by 22 publications

References 192 publications

Phytochemistry by design: a case study of the chemical composition of Ocotea guianensis optimized extracts focused on untargeted metabolomics analysis

Phytochemistry by design: a case study of the chemical composition of Ocotea guianensis optimized extracts focused on untargeted metabolomics analysis

Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells

Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

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