Alkaloids of the Papaveraceae. XLVIII. (-)-Stylopine methohydroxide, a new alkaloid from Glaucium corniculatum CURT.

Novák, V.; Dolejš, L.; Slavík, Jiří

doi:10.1135/cccc19723346

Cited by 16 publications

(3 citation statements)

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“…This result is in agreement with Shafiee et al (1985) and Novak et al (1971), reporting that the Glaucium genus stand out with its richness of alkaloid content. The total alkaloid content in different extracts were compared according to the statistical calculation and the results showed all the studied alkaloid contents varied according to plant species and extraction solvent.…”

Section: Results and Discussion Total Alkaloid Flavonoid And Phenolsupporting

confidence: 92%

The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts

Koçanci¹,

Hamamcioðlu²,

Aslım³

2017

J App Pharm Sci

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In this study, methanol and water extracts of Glaucium acutidentatum and Glaucium corniculatum were analysed for anti-AChE activity on neuronal PC12 cell and anti-proliferative activity on HT-29 and HeLa cancer cells. In this study, total alkaloid, phenol and flavonoid content were analyzed for the determination of active compounds of Glaucium acutidentatum and Glaucium corniculatum. Indeed, methanol and water alkaloid extracts of these plants were evaluated for their anti-AChE activities on NGF-differentiated PC12 cells (dPC12) and anti-proliferative activities on HT-29 and HeLa cancer cells. Our data showed that alkaloid was major compound, the different concentrations of plant extracts had 35-90% in vitro AChE inhibitory activity and 26-54% cellular AChE inhibitory activity and it is dose dependent manner. Furthermore, G. acutidentatum methanolic extracts showed the highest anti-proliferative activity in HT-29 cells (45±5%) Both 1000 μg/ml methanolic extracts showed the maximum anti-proliferative effect in HeLa cells (64±3%). In conclusion, this study has shown that the anti-AChE and anti-proliferative effects of these two plants and the presence of a new AChE inhibitor (AChEi) may be effective in AD and cancer.

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Section: Results and Discussion Total Alkaloid Flavonoid And Phenolsupporting

confidence: 92%

The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts

Koçanci¹,

Hamamcioðlu²,

Aslım³

2017

J App Pharm Sci

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“…This agreed with a previous study of this plant. Different components including alkaloid were found to be the major compound and flavonoid and phenolic contents in the G. corniculatum (L.) Curtis extract [45][46][47].…”

Section: Ftir Analysismentioning

confidence: 99%

Green synthesis of silver nanoparticles using Glaucium corniculatum (L.) Curtis extract and evaluation of its antibacterial activity

Allafchian

Jalali

Aghaei

et al. 2018

IET nanobiotechnol.

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The metal nanoparticles, due to interesting features such as electrical, optical, chemical and magnetic properties, have been investigated repeatedly. Also, the mentioned nanoparticles have specific uses in terms of their antibacterial activity. The biosynthesis method is more appropriate than the chemical method for producing the nanoparticles because it does not need any special facilities; it is also economically affordable. In the current study, the silver nanoparticles (AgNPs) were obtained by using a very simple and low-cost method via (L.) Curtis plant extract. The characteristics of the AgNPs were investigated using techniques including: X-ray diffraction, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy. The SEM and TEM images showed that the nanoparticles had a spherical shape, and the mean diameter of them was 53.7 and 45 nm, respectively. The results of the disc diffusion test used for measuring the anti-bacterial activity of the synthesised nanoparticles indicated that the formed nanoparticles possessed a suitable anti-bacterial activity.

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“…Canadine exhibited (9.07%) a molecular ion peak at m/z 339. Canadine methiodide was previously isolated from a quaternary fraction of Glaucium corniculatum (Novák, Dolejš, Slavík, 1972), but canadine is reported from G. corniculatum subsp. refractum in this study for the first time in the literature.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Chemical profile, acetylcholinesterase, butyrylcholinesterase, and prolyl oligopeptidase inhibitory activity of Glaucium corniculatum subsp. refractum

Bozkurt

Ulkar

Nurlu

et al. 2022

Braz. J. Pharm. Sci.

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Papaveraceae is one of the prominent alkaloid-containing families, and plants of the genus Glaucium (Papaveraceae) are known for their bioactive alkaloids. Glaucium species have been used in traditional medicine in Turkey as an analgesic, narcotic, sedative, and antitussive. In this study, it was planned to evaluate the inhibitory activity of an alkaloidal extract of Glaucium corniculatum subsp. refractum on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and prolyl oligopeptidase (POP), as well as exploring the chemical profile of the plant by using Gas Chromatography-Mass Spectrometry (GC-MS). The AChE, BuChE and POP inhibition activities of the alkaloidal extract of G. corniculatum subsp. refractum were determined spectrophotometrically. A rapid GC-MS method was used to identify alkaloids that could be responsible for these inhibition activities. In total, eleven alkaloids were identified in the alkaloid extract of the plant by GC-MS. Allocyptopine (52.92%) and protopine (25.38%) were found as the major constituents. The alkaloidal extract of G. corniculatum subsp. refractum showed potent AChE inhibitory activity (IC 50 :1.25 µg/mL) and BuChE inhibitory activity (IC 50 : 7.02 µg/mL). The extract also showed a remarkable inhibitory effect on POP with an IC 50 value of 123.69 µg/mL. This study presents the first GC-MS investigation and POP inhibitory activity of G. corniculatum subsp. refractum.

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Alkaloids of the Papaveraceae. XLVIII. (-)-Stylopine methohydroxide, a new alkaloid from Glaucium corniculatum CURT.

Cited by 16 publications

References 0 publications

The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts

The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts

Green synthesis of silver nanoparticles using Glaucium corniculatum (L.) Curtis extract and evaluation of its antibacterial activity

Chemical profile, acetylcholinesterase, butyrylcholinesterase, and prolyl oligopeptidase inhibitory activity of Glaucium corniculatum subsp. refractum

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