Alkalosis and Low Plasma Potassium in a Case of Cushing's Syndrome: A Metabolic Study

Willson, Donald M.; Power, Marschelle H.; Kepler, Edwin J.

doi:10.1172/jci101174

Cited by 57 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased reabsorption of bicarbonate could not be accounted for by elevations of plasma pCO2. 3. In dogs, the elevated bicarbonate reabsorption, which occurs following elevation of the plasma pCO2, is returned to normal by the administration of potassium chloride without a change in pCO2.…”

Section: Resultsmentioning

confidence: 99%

“…It is generally recognized that potassium deprivation may result in the development of a plasma alkalosis, which is characterized by the paradoxical excretion of an acid urine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Conversely, the administration of sufficient potassium chloride results in a plasma acidosis and the simultaneous excretion of an alkaline urine (8,(13)(14)(15)(16).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Potassium on Renal Tubular Reabsorption of Bicarbonate 12

Roberts¹,

Randall²,

Sanders³

et al. 1955

J. Clin. Invest.

View full text Add to dashboard Cite

It is generally recognized that potassium deprivation may result in the development of a plasma alkalosis, which is characterized by the paradoxical excretion of an acid urine (1-12). Conversely, the administration of sufficient potassium chloride results in a plasma acidosis and the simultaneous excretion of an alkaline urine (8,(13)(14)(15)(16). Studies previously reported have shown that the dichotomous plasma and urinary findings following potassium administration result from a decrease in the renal tubular reabsorption of base-bound bicarbonate (13). The inappropriate aciduria occurring in hypokalemic alkalosis has led to the suggestion that renal reabsorption of bicarbonate is increased in circumstances where inadequate intake or excessive losses of potassium have occurred (1, 13, 17). This implies a renal failure to compensate the plasma alkalosis accompanying hypokalemia and assumes a renal contribution to the continuation of the plasma alkalosis. Although it has not been measured previously, it would appear virtually certain that hypokalemia enhances the renal tubular reabsorption of bicarbonate; the mechanism whereby the influence of potassium is mediated, however, remains more speculative (1,13,17). Accordingly, the studies described herein were carried out on human subjects and on dogs 1) to determine the effects of potassium depletion on the renal mechanisms implicated in stabilizing the plasma bicarbonate, and 2) to clarify the mechanisms whereby potassium influences the renal tubular reabsorption and urinary excretion of bicarbonate bound base.The studies reported below indicate that hypokalemia results in an increased renal tubular reab-

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of Potassium on Renal Tubular Reabsorption of Bicarbonate 12

Roberts¹,

Randall²,

Sanders³

et al. 1955

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…In examining the data, four types of change in intracellular fluids will be encountered: (1) changes in the volume of intracellular water brought about by variations in the concentration of sodium in serum; (2) increase in intracellular potassium dependent on increase in the concentration of potassium in serum; (3) changes in intracellular water dependent on increase in intracellular potassium per 100 grams of fat-free solids; and (4) changes in the reciprocal relationship between muscle potassium and intracellular sodium. The last type of change is the one which is produced by alkalosis per se; but the experiments apparently show that this relation is modified by other conditions inherent in the experiments.…”

Section: Methodsmentioning

confidence: 99%

“…Analyses of the serum and muscle for the chief electrolytes are reported in (1) rats subjected to pyloric obstruction with water deprivation, (2) rats subjected to pyloric obstruction accompanied by subcutaneous injections of glucose and consequent abundance of water, (3) rats subjected to depletion of chloride while on a diet low in chloride, sodium and potassium and (4) rats subjected to depletion of chloride while on a diet deficient only in chloride.…”

Section: Sum Marymentioning

confidence: 99%

“…Willson, Power and Kepler (2) and McQuarrie, Johnson and Ziegler (3) have called attention to cases of Cushing's syndrome which have persistent alkalosis and low concentration of potassium in serum. The low serum chloride and high bicarbonate of these patients is not corrected by administration of sodium chloride or ammonium chloride, but does respond to potassium chloride.…”

mentioning

confidence: 99%

See 1 more Smart Citation