ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

m6A RNA Methylation Regulators Participate in the Malignant Progression and Have Clinical Prognostic Value in Lung Adenocarcinoma

“…Especially, it has been demonstrated that several m6A methyltransferase, such as METTL3 and YTHDF1, facilitate lung adenocarcinoma progression by activating cell migration and invasion through m6A methylation ( Lin et al, 2016 ; Shi et al, 2019 ). While FTO and ALKBH5 affect the proliferation and invasion of lung adenocarcinoma cells via regulating multiple target genes and signaling pathways which are related to malignant tumors ( Chao et al, 2020 ; Ding et al, 2020 ). The above studies have confirmed our present results to some extent that m6A RNA methylation regulators participate in the malignant progression of lung adenocarcinoma.…”

“…However, alternative therapeutic strategies for treating lung adenocarcinoma underscore their importance due to the absence of target gene mutation in a significant proportion of lung adenocarcinoma and the resistance of new targeted drugs ( Minguet et al, 2016 ). Among these strategies, epigenetics, especially RNA methylation has drawn wide attention ( Chao et al, 2020 ).…”

The biological function of m6A demethylase ALKBH5 and its role in human disease

“…Lastly, ALKBH5 was also closely related with the process of intermittent hypoxia in lung adenocarcinoma cells. Mechanistic analysis indicated that m6A demethylase ALKBH5 enhanced the proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia by down-regulating the level of m6A in FOXM1 mRNA and enhancing the translation efficiency of FOXM1 mRNA, resulting in the overexpression of FOXM1 protein [11].…”

“…Human AlkB homolog H5 (ALKBH5), was a famous m6A demethylase (also called m6A eraser), which had spawned significant biological and pharmacological interest among researchers [ 10 ]. Recently, the effects of ALKBH5 on many biological processes had been demonstrated, including proliferation [ 11 ], invasion [ 12 ], metastasis [ 13 ], ossification [ 14 ] and so on. In addition, ALKBH5 was also involved in kinds of cancers or non-cancers, such as glioblastoma [ 15 ], pancreatic cancer [ 16 ], colon cancer [ 17 ], breast cancer [ 18 ], gastric cancer [ 19 ], lung cancer [ 20 ], ovarian cancer [ 21 ], diabetes [ 22 ] and reproductive system diseases [ 23 ] (Figs.…”

N6‐methyladenosine (m6A) RNA modification in human cancer

“…All these indicate that FTO may be a potential therapeutic target in lung cancer. Intermittent hypoxia‐induced ALKBH5 amplification in lung adenocarcinoma promotes cell proliferation and invasion by decreasing the m 6 A level of FOXM1 mRNA and increasing the translation of FOXM1 mRNA 106 …”