Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies

γ‐Lactones from Persea americana and Persea fulva – in Vitro and in Silico Evaluation of Trypanosoma cruzi Activity

“…With respect to the correlated structures 4 – 6 , compound 6 was the most active (EC 50 of 3.6 μM) followed by derivatives 5 and 4 (EC 50 of 29.9 and 45.2 μM, respectively). Based on structural aspects, the data herein suggest that side chain extension plays an important role in the anti‐ T. cruzi potential, similarly to what was previously described for the antiproliferative activity [21] …”

“…NMR and ESI‐HR‐MS data of 1 – 5 were identical to those reported in the literature [8,21] for majoranolide B, majorenolide, majorynolide, lincomolide D, and isolinderanolide E, respectively ( Figure 1). However, the configuration of C‐5 was not previously determined for compounds 1 – 3 .…”

“…Details concerning the collection of P. fulva were previously reported [21] . Roots of P. americana were collected in São Paulo, SP, Brazil (−23.489090 and −46.673826) in February 2006 (SISGEN number A4123E4).…”

“…Details concerning the isolation of 1 – 3 from P. fulva leaves were previously reported [21] . Dried roots (350 g) from P. americana were grounded and extracted with hexane at room temperature to afford 3.6 g of crude extract.…”

“…Additionally, γ‐lactones isolated from Lauraceae species have been shown to possess diverse biological activities, such as antimycobacterial, [9] anti‐inflammatory [10] and cytotoxic activities [8,11,13,19,20] . In a previous study, [21] four alkene‐γ‐lactones isolated from leaves of Persea fulva showed antiproliferative activity against tumor cells in vitro .…”