Alkyl trimethyl ammonium bromide for the formulation of antibacterial orthodontic resins

Balbinot, Gabriela de Souza; Marcon, Nicóly; Sauro, Salvatore; Meléndez, Santiago de Luxán; Collares, Fabrício Mezzomo

doi:10.1007/s00784-022-04661-0

Cited by 8 publications

(9 citation statements)

References 46 publications

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“…145 The inclusion of alkyl trimethylammonium bromide in orthodontic resins also leads to a decrease in the viability of biofilm and planktonic forms of bacteria. 146 Studies of dental adhesives containing benzyldimethyldodecylammonium chloride showed that an expressive bacterial reduction occurred on biofilms grown on QAC-modified samples. 90 The addition of QACs to commercial giomers enables good antibacterial activity and great potential to regulate the compositions of cariogenic biofilms.…”

Section: ■ Qac-embedded Coatings As a Promising Strategy For Biofilm ...mentioning

confidence: 99%

“…S. mutans , , S. aureus , ,, S. epidermidis , , E. coli , ,, and C. albicans biofilms are the most frequently studied subjects. The testing of biofilms at 24–48 h is described in most sources. ,, However, long-term studies of 7, 14, and 21 day biofilms are also available.…”

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

“…S. mutans, 90,146 S. aureus, 147,148,150 S. epidermidis, 149,156 E. coli, 150,152,157 and C. albicans 158 biofilms are the most frequently studied subjects. The testing of biofilms at 24−48 h is described in most sources.…”

Section: ■ Qac-embedded Coatings As a Promising Strategy For Biofilm ...mentioning

confidence: 99%

“… Thus, a simple inclusion of quaternary ammonium dimethylaminohexadecyl methacrylate in the dental resin structure enables significant bacterial cell destruction in the composition of two-day biofilms . The inclusion of alkyl trimethylammonium bromide in orthodontic resins also leads to a decrease in the viability of biofilm and planktonic forms of bacteria . Studies of dental adhesives containing benzyldimethyldodecylammonium chloride showed that an expressive bacterial reduction occurred on biofilms grown on QAC-modified samples .…”

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

“…Biofilm formation on a QAC-modified sample is the most commonly studied. The main testing methods for antibiofilm activity are colony-forming unit (CFU) counting assay, ,− live/dead biofilm staining assay, ,,− and biofilm observation using scanning electron microscopy (SEM). ,,− The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay of biofilm metabolic activity ,,, and lactic acid production measurement were also used (Figure ).…”

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

See 4 more Smart Citations

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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In a previous development stage, mostly individual antibacterial activity was a target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, a new trend has appeared since the discovery of superhigh resistance of bacterial cells upon their aggregation into groups. Indeed, it is now well established that the great majority of pathogenic germs are found in the environment as surface-associated microbial communities called biofilms. The protective properties of biofilms and microbial resistance, even to high concentrations of biocides, cause many chronic infections in medical settings and lead to serious economic losses in various areas. A paradigm shift from individual bacterial targeting to also affecting more complex cellular frameworks is taking place and involves multiple strategies for combating biofilms with compounds that are effective at different stages of microbiome formation. Quaternary ammonium compounds (QACs) play a key role in many of these treatments and prophylactic techniques on the basis of both the use of individual antibacterial agents and combination technologies. In this review, we summarize the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. As an important focus, techniques for developing and applying antimicrobial coatings that prevent the formation of biofilms on various surfaces over time are discussed. The information analyzed in this review will be useful to researchers and engineers working in many fields, including the development of a new generation of applied materials; understanding biofilm surface growth; and conducting research in medical, pharmaceutical, and materials sciences. Although regular studies of antibacterial activity are still widely conducted, a promising new trend is also to evaluate antibiofilm activity in a comprehensive study in order to meet the current requirements for the development of highly needed practical applications.

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Section: ■ Qac-embedded Coatings As a Promising Strategy For Biofilm ...mentioning

confidence: 99%

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

Section: ■ Qac-embedded Coatings As a Promising Strategy For Biofilm ...mentioning

confidence: 99%

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

Section: Qac-embedded Coatings As a Promising Strategy For Biofilm Co...mentioning

confidence: 99%

See 3 more Smart Citations

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

et al. 2023

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Influence of titanium dioxide nanotubes with alkyl ammonium alkyl bromide on the physicochemical properties and adhesion of experimental adhesive resins to dentin

Araújo-Neto,

Garcia,

Balbinot

et al. 2024

International Journal of Adhesion and Adhesives

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Silver core-shells particles as antibacterial filler for adhesive resins

Balbinot,

Leitune,

Montenegro

et al. 2025

International Journal of Adhesion and Adhesives

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Alkyl trimethyl ammonium bromide for the formulation of antibacterial orthodontic resins

Cited by 8 publications

References 46 publications

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

Influence of titanium dioxide nanotubes with alkyl ammonium alkyl bromide on the physicochemical properties and adhesion of experimental adhesive resins to dentin

Silver core-shells particles as antibacterial filler for adhesive resins

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