Alkylation of Benzoyl and Furoylthioureas as Polydentate Systems

On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N′-acyl thioureas

“…The solid N,N-disubstituted-N′-acyl thioureas were collected by filtration and finally purified by recrystallization from ethanol. The identity of the products was confirmed by comparing their 1 H and 13 C NMR data with those reported in the literature [24]. The structures of the ligands are shown in Fig.…”

“…The molecular structures of the complexes were also investigated by NMR ( NMR spectra of the free ligands show basically three sets of well separated signals corresponding to their R1, R2 substituent and to the NH proton. The signals of the NH protons appear as broad singlets in the region between 8.35 and 8.80 ppm [24]. The absence of the N\H proton after the coordination of the ligands to the metal is associated with an increase in electron density at the C\N bond upon complexation [42,43].…”

“…In all complexes the Pd(II) ion is nearly planar, fourfold environment. The thione C_S bond in the coordinated anionic ligands becomes formally a single bond making it longer (average = 1.7418 Å) than the C_S bond of the neutral moieties [24,25], and the N(2)\C bond (average 1.3252 Å) (Fig. 2, Table 2), which becomes a double bond in the anionic moieties, is typical for C_N distances [44].…”

“…Detailed descriptions of syntheses and characterization of ligands have been reported elsewhere [24]. A solution of an appropriately acyl chloride (30 mmol) in acetone (50 mL) was added drop wise to a suspension of KSCN (0.01 mol) in acetone (30 mL).…”

“…The N,N-disubstituted-N′-acyl thioureas used as ligands in this work were synthesized by the procedure previously reported in literature [24]. Scheme 1 shows the pathway for the synthesis of the Pd(II) complexes, which were obtained by reacting methanolic solutions of acyl thioureas with the precursor, the dichloro(bistriphenylphosphine)palladium(II).…”