Alkylation of DNA and proteins in mice exposed to vinyl chloride

Osterman-Golkar, Siv; Hultmark, Dan; Segerbäck, Dan; Calleman, Carl Johan; Göthe, Rolf; Ehrenberg, L.; Wachtmeister, C. A.

doi:10.1016/0006-291x(77)90720-3

Cited by 120 publications

(36 citation statements)

References 15 publications

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“…At that time too, Osterman-Golkar et al (1977) showed the chromatographic separation, after NaBH4 treatment, of 7-N-(2-hydroxyethyl)guanine from the acid hydrolysate of the liver DNA of mice, exposed acutely to 14C-vinyl chloride, and they attributed this result to formation of 7-N-(2-oxoethyl)dG residues, but they did not look in their DNA hydrolysates for etheno-dA and etheno-dC, which, on account of the method of exposure, may have been absent from their material or below the limits of detection.…”

Section: Mechanisms Of Vinyl Chloride Carcinogenicity/mutagenicitymentioning

confidence: 97%

Mechanisms of vinyl chloride carcinogenicity/mutagenicity

Hathaway¹

1981

Br J Cancer

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Section: Mechanisms Of Vinyl Chloride Carcinogenicity/mutagenicitymentioning

confidence: 97%

Mechanisms of vinyl chloride carcinogenicity/mutagenicity

Hathaway¹

1981

Br J Cancer

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“…Biological monitoring using hemoglobin adducts is being used in ethylene 31,32) , propylene oxide 33) , acrylamide 34) , vinyl chloride 35) , and benzo(a)pyrene 36,37) . Active studies are being conducted on hemoglobin adducts of nitrosoamine and 4-aminobiphenyl which are related with smoking 38,39) .…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanol and Phenobarbital on Hemoglobin Adducts Formation in Rats Exposed to Benzidine and Direct Black 38

et al. 2009

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“…The carcinogenicity findings with VC led to studies on its metabolism (7) and possible modes of action (5,8,9). Simultaneously studies were undertaken in a number of laboratories on other compounds in this class, some of which are also being examined in our laboratory.…”

Section: Introductionmentioning

confidence: 99%

Chemical Structure, Reactivity, and Carcinogenicity of Halohydrocarbons

Duuren¹

1977

Environmental Health Perspectives

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This review summarizes studies concerning the covalent binding of [14C]TCE to rat liver microsomal protein and exogenous DNA, in vitro, the enhancement of this binding by inducers of mixed-function oxidases, and inhibition of binding by inhibitors of these enzymes. Furthermore, recent studies on this type of binding in various strains of mice and rats of both sexes and using microsomal preparations from various organs are briefly reviewed. Other work reviewed here concerns the synthesis of TCE epoxide and its reaction with nucleophiles since it is believed that TCE epoxide is the activated carcinogenic intermediate of TCE. The utility of structural prognostication of carcinogenic activity and the importance of considering possible metabolic pathways for other chlorinated olefins is also discussed.

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Alkylation of DNA and proteins in mice exposed to vinyl chloride

Cited by 120 publications

References 15 publications

Mechanisms of vinyl chloride carcinogenicity/mutagenicity

Mechanisms of vinyl chloride carcinogenicity/mutagenicity

Effects of Ethanol and Phenobarbital on Hemoglobin Adducts Formation in Rats Exposed to Benzidine and Direct Black 38

Chemical Structure, Reactivity, and Carcinogenicity of Halohydrocarbons

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