All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor

Xiong, Yuan; Chen, Lang; Liu, Pei; Yu, Tao; Lin, Changjian; Yan, Chenchen; Hu, Yiqiang; Zhou, Wu; Sun, Yun; Panayi, Adriana C.; Cao, Faqi; Xue, Hang; Hu, Liangcong; Lin, Ze; Xie, Xudong; Xiao, Xiufeng; Qian, Feng; Mi, Bobin; Liu, Guohui

doi:10.1002/smll.202104229

Cited by 208 publications

(126 citation statements)

References 52 publications

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“…From a therapeutic perspective, previous studies have pointed out that the self-levitating nanofiber gel-encapsulated polydeoxyribonucleotide benefits chronic ulcer in diabetic rats (Chen et al, 2016). The research of Xiong Y et al indicates that chronic diabetic wound repair benefits from the nanohydrogel material loaded with growth factors (Xiong et al, 2021). At present, clinical trials have confirmed that miRNA is a key regulatory molecule of fracture healing and is likely to be a pathway to promote normal physiologic fracture healing.…”

Section: Discussionmentioning

confidence: 98%

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis

Yan

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system, have been widely applied in the treatment of diabetic wounds. Endovascular cells are important component cells of the vascular wall. Herein, we investigated the effects of HUCMSCs and HUC-Exos (exosomes secreted by HUCMSCs) on diabetic wound healing. In this study, HUVECs were coincubated with HUCMSCs, and HUC-Exos were utilized for in vitro and in vivo experiments to verify their roles in the regulation of diabetic wound healing. Our results demonstrated that HUCMSCs have the ability to regulate oxidative stress injuries of endothelial cells through exosomes and accelerate diabetic cutaneous wound healing in vitro. The present study suggests that HUC-Exos accelerate diabetic cutaneous wound healing, providing a promising therapeutic strategy for chronic diabetic wound repair.

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Section: Discussionmentioning

confidence: 98%

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis

Yan

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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“…Through a continuous supply of O 2 and timed release of ExosM2@miR-223 and FGF-2, the HA@MnO2/FGF-2/Exos hydrogel creates an appropriate immune microenvironment to improve the healing of DW in vivo. 137 Although the application of traditional biomaterials and wound dressings contributes to an effective wound healing outcome, DW repair is a dynamic and complex process. Excessive inhibition of wound inflammation is harmful.…”

Section: Targeted Immunotherapy For Dwmentioning

confidence: 99%

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Song¹,

Hu²,

Liu³

et al. 2022

JIR

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Poor wound healing in individuals with diabetes has long plagued clinicians, and immune cells play key roles in the inflammation, proliferation and remodeling that occur in wound healing. When skin integrity is damaged, immune cells migrate to the wound bed through the actions of chemokines and jointly restore tissue homeostasis and barrier function by exerting their respective biological functions. An imbalance of immune cells often leads to ineffective and disordered inflammatory responses. Due to the maladjusted microenvironment, the wound is unable to smoothly transition to the proliferation and remodeling stage, causing it to develop into a chronic refractory wound. However, chronic refractory wounds consistently lead to negative outcomes, such as long treatment cycles, high hospitalization rates, high medical costs, high disability rates, high mortality rates, and many adverse consequences. Therefore, strategies that promote the rational distribution and coordinated development of immune cells during wound healing are very important for the treatment of diabetic wounds (DW). Here, we explored the following aspects by performing a literature review: 1) the current situation of DW and an introduction to the biological functions of immune cells; 2) the role of immune cells in DW; and 3) existing (or undeveloped) therapies targeting immune cells to promote wound healing to provide new ideas for basic research, clinical treatment and nursing of DW.

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“…Adding bioactive substances that can deliver oxygen to the hydrogel can effectively improve the hypoxic microenvironment of the skin and promote vascular regeneration. For example, spirulina can release oxygen (Figure 2H) 57 under laser irradiation; NOX powder can deliver dissolved oxygen to the wound site; 25 oxygen microsphere oxygen‐release microsphere can maintain oxygen release for at least 2 weeks; 26 manganese dioxide (MnO 2 ) nanosheets can induce the decomposition of endogenous ROS (H 2 O 2 ) into oxygen (O 2 ) 27 . Proanthocyanidin B2, 28 cinnamaldehyde, 29 tannic acid, 30 polydopamine nanoparticles, 31 epigallocatechin gallate (EGCG), 32 and hydrogel dressings have significant free radical scavenging and antioxidant properties, which can remove ROS produced in hypoxic wounds and inhibit excessive inflammation and promote wound angiogenesis.…”

Section: Application Of Biomaterials In Tissue Engineering Vasculariz...mentioning

confidence: 99%

Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases

Zhao

Zhu

Hang

et al. 2022

MedComm – Biomaterials and Applications

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The formation of the complex and fully functional vascular networks in pivotal organs is a key challenge in tissue engineering research. Functional blood vessels not only maintain oxygen and nutrient delivery but also effectively get rid of waste. Recently, a deep understanding of the vascular tissue structure and tissue microenvironment helps to make several great progress in the construction of highly complex and biomimetic vascularized tissues and organs, using biomaterials such as hydrogels and biomaterial composites. In this review, we summarized the advantages and research progress of biomaterials used in constructing the vascularized tissue in tissue engineering regeneration, ischemic fibrosis, and so on. We also discussed the progression of vascularization in organs and organoids. First, we discuss the applications of biomaterial-based vascularized tissue in bone, skin, and other tissue regeneration. Secondly, we discussed biomaterials and their components in promoting vascularization of ischemic fibrosis organs such as cerebral infarction, myocardial infarction, and renal fibrosis. In addition, we also introduced the strategies and applications that biomaterials function as a biomimetic extracellular matrix performed to construct vascularized tissues or organs in vitro. Finally, coming opportunities and challenges are also discussed and commented on.

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All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor

Cited by 208 publications

References 52 publications

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases

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