All-in-one terahertz taste sensor: integrated electronic and bioelectronic tongues

Wang, Jin; Sakai, Kenji; Kiwa, Toshihiko

doi:10.1039/d3sd00038a

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…In contrast, refractive index sensing based on local surface plasmon resonance (LSPR) has found wide utility in sensing various target molecules by employing surface chemistry to anchor target molecules via specific binding processes. − This approach offers exceptional sensing fidelity with a high limit of detection, e.g ., endotoxin detection for food and pharmaceutical industries, and diagnostics for COVID-19, , ebola virus, and prostate-specific antigen . However, it is limited by the fact that the LSPR color is solely determined by the effective refractive index of the surrounding medium, − regardless of the specific type of molecules present.…”

Section: Introductionmentioning

confidence: 99%

Binding-Free Taste Visualization with Plasmonic Metasurfaces

Lee,

Kim,

Kim

et al. 2024

ACS Appl. Mater. Interfaces

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Taste sensors using photonics, termed artificial photonic tongues, have emerged as a promising platform for intuitive taste discrimination. However, the need for complex binding protocols for each taste profile limits their applicability to a narrow range of taste molecules. Here, we introduce an intriguing “binding-free” approach to molecular taste sensing using plasmonics, eliminating the requirement for physical or chemical binding protocols. We develop a wafer-scale plasmonic metasurface constructed by coating metallic nanoparticles in a scalable manner onto a metallic mirror. This metasurface functions to detect molecular refractive indices and surface tensions via 2D projection optical images of an array of liquid droplets containing the taste molecules on top, which can immediately visualize and distinguish between the five basic tastes of molecules (including their mixtures) as well as other additional spicy and alcoholic tastes. We anticipate that this intuitive and rapid taste-sensing approach has the potential to establish a user-friendly and portable taste-sensing platform.

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Section: Introductionmentioning

confidence: 99%

Binding-Free Taste Visualization with Plasmonic Metasurfaces

Lee,

Kim,

Kim

et al. 2024

ACS Appl. Mater. Interfaces

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“…In recent years, our group has used terahertz microscopy to visualize chemical reactions and applied it to the detection and evaluation of substances. For example, it has been used to rapidly assess the binding of certain substances to cancer cells, providing an innovative approach to the evaluation, detection, and analysis of substances and playing an important role in many areas of research, including the early diagnosis of cancer and the visualization and detailed information on the chemical reactions and behavior of substances in vivo. ,,− This technique uses terahertz chemical microscopy (TCM) to visualize the distribution of chemical reactions, such as antigen–antibody reactions, without labels or fluorescent markers. Antigen–antibody reactions were observed as the first demonstration of the label-free immunoassay using TCM. , In other words, the interaction between antigens and antibodies can be directly observed without the need to modify or label them with additional molecules.…”

mentioning

confidence: 99%

Label-Free Measurement of CD63 Positive Extracellular Vesicles Using Terahertz Chemical Microscopy

Liu,

Wang,

Negishi

et al. 2024

ACS Sens.

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Extracellular vesicles (EVs) are small cellular organelles involved in intracellular signaling and cell-to-cell interactions. Recent studies suggested that exosomes may have potential applications in the diagnosis and treatment of cancer and neurodegenerative diseases. In this study, extracellular vesicles of the human nonsmall cell lung cancer cell line H1299 and the unlabeled antiCD63 antibody were imaged using a new label-free terahertz chemical microscopy (TCM) technique to detect changes in the terahertz wave amplitude. To verify the high specificity of the protein biomarkers and the sensitivity of the biosensor surface, we also confirmed the selective binding of the antibody to the antigen, bovine serum albumin, and cancer cells. We also performed realtime measurements of the interaction between EVs from the H1299 cell and the antiCD63 antibody, which showed that the amount of change in the terahertz intensity increased with increasing concentration and the time to saturation decreased. Finally, to reuse the used biosensors (sensing plates), plasma−oxygen cleaning was used, and the activity of the biosensor surface was confirmed by terahertz microscopy and atomic force microscopy and was found to be reusable after less than 3 min of cleaning. Consequently, terahertz chemical microscopy was able to detect the presence or absence of antigen−antibody binding and its reaction rate and binding strength.

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Rational Design of Triboelectric Materials and Devices for Self‐Powered Food Sensing

Bai,

Zhao,

Cai

et al. 2024

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Against the backdrop of rapid advancements in 5G and Internet of Things (IoT) technologies, there is an urgent need to upgrade food sensing systems to achieve automation, digitalization, and intelligence. However, this transformation process faces numerous challenges. Triboelectric nanogenerators (TENGs), as an emerging energy conversion and sensing technology, play a crucial role in this context. They not only provide power to functional devices but also serve as sensors in multifunctional self‐powered food sensing systems, capable of detecting various physical and chemical information. This review explores the development of TENGs in the field of food sensing, focusing on the working principles of their self‐powered sensing. The review also systematically organizes and classifies the material and device designs used for TENGs in various food applications. Based on the performance of TENGs, a detailed introduction is provided on the specific applications of self‐powered food sterilization, self‐powered food quality monitoring, and self‐powered taste sensing in the field of food safety. Finally, this paper discusses the challenges and corresponding strategies of TENGs in the food sensing field. The aim is to further promote unmanned and smart services and management in the food sector and to provide new research perspectives.

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All-in-one terahertz taste sensor: integrated electronic and bioelectronic tongues

Abstract: Taste sensors, also known as electronic tongues or bioelectronic tongues, are designed to evaluate food and beverages, as well as for medical diagnostics. This device mimics the ability of the...

Cited by 6 publications

References 60 publications

Binding-Free Taste Visualization with Plasmonic Metasurfaces

Binding-Free Taste Visualization with Plasmonic Metasurfaces

Label-Free Measurement of CD63 Positive Extracellular Vesicles Using Terahertz Chemical Microscopy

Rational Design of Triboelectric Materials and Devices for Self‐Powered Food Sensing

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