All‐in‐One Zeolite–Carbon‐Based Nanotheranostics with Adjustable NIR‐II Window Photoacoustic/Fluorescence Imaging Performance for Precise NIR‐II Photothermal‐Synergized Catalytic Antitumor Therapy

Abstract

In the second near‐infrared (NIR‐II) biowindow, multimodal optical imaging‐guided precise antitumor therapy is a novel strategy for high‐efficiency tumor theranostics, however, the all‐in‐one dual NIR‐II photoacoustic (NIR‐II PA) and NIR‐II fluorescence (NIR‐II FL) nanoprobes have been rarely reported mainly due to the short of a simple and universal design approach. Herein, a NIR‐II PA/NIR‐II FL imaging‐adjustable nanozyme (HSC‐2) is designed and developed to guide precise photothermal‐catalytic synergistic therapy. Based on the ionic liquids adsorption capacity, the electronic structure of zeolite nano‐Beta (three dimensional 12‐ring pore system and large surface area) can be turned from the indirect band gap to direct band gap via doping carbon in the framework, resulting in outstanding NIR‐II FL emission characteristics. As the silicon etching reaction proceeds, HSC‐2 shows superior dual‐modal NIR‐II PA/NIR‐II FL imaging performance facilitated by the optimal silicon‐to‐carbon ratio, simultaneously ensuring efficient tumor photothermal therapy (PTT) in the NIR‐II window. Impressively, the peroxidase‐mimic activity of HSC‐2 in the tumor microenvironment could be further remarkably enhanced by its photothermal effect, leading to excellent synergistic PTT/catalytic therapy. Moreover, the HSC‐2 exhibits dual‐enzyme activity, and its catalase‐like property could effectively eliminate excessive ROS for protection of the normal cells.

Novel Strategy for Optimized Nanocatalytic Tumor Therapy: From an Updated View

“…As such, the in-depth studies of the molecular mechanism of NCT combating tumor cells should also be highlighted, which would promote the development of NCT on pharmacological research, targeted therapy, and further clinical application. 3) Third, the process of Catalytic reaction Nanozyme Fe, Cu, Mn, Ce, MOF-based nanocomposites [11] Surface modification [24] Morphological (2D) nanozyme [26] SACs [29] TME modulating Co-loaded catalysts to promote sequential catalytic reactions [32b,34] Self-amplified H 2 O 2 level [35,36] Improving the GSH/pH condition [37,40] Construction of multifunctional nanosystems Synergistic therapy NCTþchemotherapy [13] NCTþstimuli-responsive therapy [45][46][47][48] NCT þ PDT/ PTT [44] NCTþgene-editing therapy [50] NCTþimmumotherapy [53,57] Targeted therapy / Vehicle mediated [41] Surface ligand mediated [43] Theranostic applications / Fluorescence imaging-guided NCT [59] PA-guided NCT [61] Multimodal imaging-monitored NCT [60] a)…”

“…Diagnostic imaging in the NIR‐II biowindow has emerged as a novel strategy for highly precise tumor detection in latest researches. Zheng et al [ 60 ] lately developed a NIR‐II photoacoustic (PA)/NIR‐II fluorescence imaging‐monitored nanozyme (HSC‐2) to guide precise synergistic PTT‐catalytic antitumor therapy ( Figure 11D,E ) . Due to the adsorption capacity of ionic liquid, the electronic structure of the zeolite nano‐Beta could be turned from the indirect bandgap to direct bandgap via doping carbon in the framework, thus endowing it with remarkable performance in NIR‐II fluorescence emission.…”

“…F) PA images of tumor in mice at different time points after intratumor injection of HSC-2 under 808 nm laser (0.3 W cm À2 ) irradiation (1064 nm) and NIR-II fluorescence images of 4T1 tumor-bearing mice after systemic administration of HSC-2 (1000 LP and 100 ms). Reproduced with permission [60]. Copyright 2021, Wiley-VCH.…”

Injectable Hydrogel Based on Defect‐Rich Multi‐Nanozymes for Diabetic Wound Healing via an Oxygen Self‐Supplying Cascade Reaction

“…CAT-like activity was evaluated by monitoring the generation of O 2 by the catalytic decomposition of H 2 O 2 . [47,48] As shown in Figure 4f,g, MoS 2 @Au@BSA and MoS 2 @Au NSs generated significantly higher levels of O 2 compared to the other groups; therefore, H 2 O 2 depletion was greatest with these materials, indicating remarkable CAT-like activity. MoS 2 @Au@BSA exhibited the highest scavenging activity against the three representative ROS, and the final products of the antioxidant system were H 2 O and O 2 (Figure 4h).…”

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

“…SCP S have a conjugated structure and high stability, and its boundary contains hydrophilic groups, which has good biocompatibility 5 and essentially prevents the toxic side effects of heavy metal ions and small molecules on the organism compared with inorganic semiconductors TiO 2 , 6 ZnSe/ZnS, 7 and CdSe. 8 These properties promote the application of SCP S in the biomedical field, such as fluorescence imaging, [9][10][11] PDT, 12,13 photothermal therapy (PTT), 14,15 and antibacterial application. 16,17…”