All night spectral analysis of EEG sleep in young adult and middle-aged male subjects

Dijk, Derk Jan; Beersma, Domien; Hoofdakker, R.H. van den

doi:10.1016/0197-4580(89)90004-3

Cited by 164 publications

(109 citation statements)

References 19 publications

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“…They typically displayed a low sleep efficiency, which was not due to abnormal sleep onset latencies, but due to a high amount of intermittent wakefulness, particularly during the second part of the night. Although considerable for their age, the amount of slow wave sleep is lower than that usually observed in young subjects (eg Dijk et al, 1989;Landolt et al, 1996;Mathias et al, 2001). The age-related reduction in slow wave sleep is reportedly associated with a decrease in the amplitude (Feinberg et al, 1967) and number (Ehlers and Kupfer, 1989) of slow waves and, consequently, with an attenuation of spectral power density in the delta frequencies (Dijk et al, 1989;Ehlers and Kupfer, 1989;Landolt et al, 1996).…”

Section: Discussionmentioning

confidence: 74%

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Mathias

Zihl

Steiger

et al. 2004

Neuropsychopharmacol

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Aging is associated with dramatic reductions in sleep continuity and sleep intensity. Since gaboxadol, a selective GABA A receptor agonist, has been demonstrated to improve sleep consolidation and promote deep sleep, it may be an effective hypnotic, particularly for elderly patients with insomnia. In the present study, we investigated the effects of subchronic gaboxadol administration on nocturnal sleep and its residual effects during the next days in elderly subjects. This was a randomized, double-blind, placebo-controlled, balanced crossover study in 10 healthy elderly subjects without sleep complaints. The subjects were administered either placebo or 15 mg gaboxadol hydrochloride at bedtime on three consecutive nights. Sleep was recorded during each night from 2300 to 0700 h and tests assessing attention (target detection, stroop test) and memory function (visual form recognition, immediate word recall, digit span) were applied at 0900, 1400, and 1700 h during the following days. Compared with placebo, gaboxadol significantly shortened subjective sleep onset latency and increased self-rated sleep intensity and quality. Polysomnographic recordings showed that it significantly decreased the number of awakenings, the amount of intermittent wakefulness, and stage 1, and increased slow wave sleep and stage 2. These effects were stable over the three nights. None of the subjects reported side effects. Next-day cognitive performance was not affected by gaboxadol. Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects.

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Section: Discussionmentioning

confidence: 74%

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Mathias

Zihl

Steiger

et al. 2004

Neuropsychopharmacol

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“…Its level and time-course are thought to be reflected in slow-wave E E G activity. There is considerable evidence that slow-wave sleep parameters undergo significant changes as a function of aging (Feinberg and Carlson 1968;Ingram et al 1982;Webb and Dreblow 1982;Reynolds et al 1985a;Ehlers and Kupfer 1989;Dijk et al 1989b). Delta power, as well as absolute delta count, may be reduced in older individuals.…”

Section: Discussionmentioning

confidence: 99%

Aging young sleep: a test of the phase advance hypothesis of sleep disturbance in the elderly

Campbell

Dawson

1992

Journal of Sleep Research

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S U M M A R YWith aging, the phase relationship between sleep a n d body core temperature is altered such that the temperature minimum occurs substantially earlier in the major nocturnal sleep period. T h e sleep maintenance difficulties that often accompany normal aging a r e generally assumed t o b e associated with this age-related change in the phase angle between sleep and temperature. To test this notion, we used timed exposure t o bright light t o reproduce in healthy young adults a similar phase relationship between temperature and sleep, t o determine If. such a manipulation would induce the same fragmented nocturnal sleep commonly observed in individuals over 65 years of age. Seven young adults were exposed to morning bright light for 3 consecutive days following a baseline night. Bright light exposure caused a 97 min phase advance of the fitted temperature minimum when compared with baseline. Significant declines in several measures of sleep quality were associated with the phase advance, including wakefulness after initial sleep onset (WASO), sleep efficiency and number of stage changes. Yet, the severity of sleep disturbance exhibited by these subjects did not approach that exhibited by most elderly subjects. T h e findings suggest that while chronophysiological changes appear to be strongly associated with the tendency to awaken in the early morning, they cannot account entirely for the severity of sleep disturbance frequently observed in older subjects.

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“…The decline in sleep consolidation, together with the advance of sleep timing, may reflect age-related changes in the homeostatic and/or circadian aspects of sleep regulation (Cajochen et al, 2006;Dijk et al, 1999). From the sleep homeostatic perspective, older people display a shallower dissipation of sleep pressure, as indexed by reduced SWS and slow wave activity (SWA) (electroencephalographic [EEG] power density between 0.75 and 4.5 Hz, also referred to as delta activity) dynamics across the night (Dijk and Beersma, 1989;Landolt et al, 1996). From a circadian standpoint, aging can be associated with a reduced circadian amplitude of the core body temperature (CBT) rhythm, and a phase advance of the CBT and melatonin rhythm .…”

Section: Introductionmentioning

confidence: 99%

Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

Viola

Chellappa

Archer

et al. 2012

Neurobiology of Aging

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Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeostatic sleep regulation in young volunteers are associated with the variable-number, tandem-repeat (VNTR) polymorphism (rs57875989) in the coding region of the circadian clock gene PERIOD3 (PER3). However, predictors of these interindividual differences have yet to be identified in older people. Sleep electroencephalographic (EEG) characteristics and circadian rhythms were assessed in 26 healthy older volunteers (55-75 years) selected on the basis of homozygosity for either the long or short allele of the PER3 polymorphism. Homozygosity for the longer allele (PER3 5/5 ) associated with a phase-advance in the circadian melatonin profile and an earlier occurrence of the melatonin peak within the sleep episode. Furthermore, older PER3 5/5 participants accumulated more nocturnal wakefulness, had increased EEG frontal delta activity (0.75-1.50 Hz), and decreased EEG frontal sigma activity (11-13 Hz) during non-rapid eye movement (REM) sleep compared with PER3 4/4 participants. Our results indicate that the polymorphism in the clock gene PER3 may contribute to interindividual differences in sleep and circadian physiology in older people.

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All night spectral analysis of EEG sleep in young adult and middle-aged male subjects

Cited by 164 publications

References 19 publications

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Aging young sleep: a test of the phase advance hypothesis of sleep disturbance in the elderly

Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

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