All-optical structuring of laser-driven proton beam profiles

Obst-Huebl, Lieselotte; Ziegler, Tim; Brack, Florian‐Emanuel; Branco, João; Bußmann, Michael; Cowan, T. E.; Curry, C. B.; Fiúza, Frederico; Garten, Marco; Gauthier, M.; Göde, S.; Glenzer, S. H.; Huebl, Axel; Irman, Arie; Kim, Jongjin B.; Kluge, T.; Kraft, Stephan; Kroll, Florian; Metzkes-Ng, Josefine; Pausch, Richard; Prencipe, Irene; Rehwald, Martin; Roedel, Christian; Schlenvoigt, Hans-Peter; Schramm, U.; Zeil, Karl

doi:10.1038/s41467-018-07756-z

Cited by 19 publications

(15 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a consequence, tailored transport and beam shaping www.nature.com/scientificreports www.nature.com/scientificreports/ techniques have to be used to prepare application specific beam parameters 10,[33][34][35][36] . Ideally, innovative laser plasma based concepts [37][38][39] might be exploited for initial beam manipulation. Capture, transport and focusing of the strongly divergent and broad bandwidth proton beams represent the most challenging task.…”

mentioning

confidence: 99%

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Brack

Kroll

Gaus

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Intense laser-driven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for 3D. Here we experimentally show the successful implementation of a highly efficient (50% transmission) and tuneable dual pulsed solenoid setup to generate a homogeneous (laterally and in depth) volumetric dose distribution (cylindrical volume of 5 mm diameter and depth) at a single pulse dose of 0.7 Gy via multi-energy slice selection from the broad input spectrum. The experiments were conducted at the Petawatt beam of the Dresden Laser Acceleration Source Draco and were aided by a predictive simulation model verified by proton transport studies. With the characterised beamline we investigated manipulation and matching of lateral and depth dose profiles to various desired applications and targets. Using an adapted dose profile, we performed a first proof-of-technical-concept laser-driven proton irradiation of volumetric in-vitro tumour tissue (SAS spheroids) to demonstrate concurrent operation of laser accelerator, beam shaping, dosimetry and irradiation procedure of volumetric biological samples.

show abstract

mentioning

confidence: 99%

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Brack

Kroll

Gaus

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…As a consequence, tailored transport and beam shaping techniques have to be used to derive application specific beam parameters 10,[31][32][33][34] . Ideally, innovative laser plasma based concepts [35][36][37] can be applied, but mostly beamlines comprise conventional devices based on permanent magnets. Capture, collimation, and focusing of the strongly divergent proton beams represent the most challenging tasks.…”

Section: Introductionmentioning

confidence: 99%

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Brack¹,

Kroll²,

Gaus³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Intense laser-driven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for 3D. Here we experimentally show the successful implementation of a highly efficient (50 % transmission) and tuneable dual pulsed solenoid setup to generate a homogeneous (8.5 % uniformity laterally and in depth) volumetric dose distribution (cylindrical volume of 5mm diameter and depth) at a single pulse dose of 0.7 Gy via multi-energy slice selection from the broad input spectrum. The experiments have been conducted at the Petawatt beam of the Dresden Laser Acceleration Source Draco and were aided by a predictive simulation model verified by proton transport studies. With the characterised beamline we investigated manipulation and matching of lateral and depth dose profiles to various desired applications and targets. Using a specifically adapted dose profile, we successfully performed first proof-of-concept laser-driven proton irradiation studies of volumetric in-vivo normal tissue (zebrafish embryos) and in-vitro tumour tissue (SAS spheroids) samples.

show abstract

“…Numerous high-power laser facilities that are upcoming, in construction or in commissioning, representing a cumulative impressive investment of almost 1 B€, have therefore the production of secondary sources as one of their key topics [2][3][4][5][6][7][8] . Concerning the field of laser-driven proton acceleration, as produced during the interaction of a high-intensity (I > 1 × 10 18 W/cm 2 ), short pulse (<1 ps) laser with a solid target 9 , several laboratories are working on setting up laser-driven proton sources for utilization of those novel particles [10][11][12][13][14][15][16][17][18] . Current applications of laser-accelerated particles (particularly protons) 19,20 include their use as bright ultra-short neutron sources 21,22 , for producing warm-dense matter 23 , in medicine [24][25][26][27] , for picosecond metrology 28 , as diagnostics in the Cultural Heritage , as well as for stressing and testing materials [33][34][35][36] .…”

mentioning

confidence: 99%

Ultra-Fast High-Precision Metallic Nanoparticle Synthesis using Laser-Accelerated Protons

Barberio

Giusepponi

Vallières

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Laser-driven proton acceleration, as produced during the interaction of a high-intensity (i > 1 × 10 18 W/cm 2), short pulse (<1 ps) laser with a solid target, is a prosperous field of endeavor for manifold applications in different domains, including astrophysics, biomedicine and materials science. These emerging applications benefit from the unique features of the laser-accelerated particles such as short duration, intense flux and energy versatility, which allow obtaining unprecedented temperature and pressure conditions. In this paper, we show that laser-driven protons are perfectly suited for producing, in a single sub-ns laser pulse, metallic nanocrystals with tunable diameter ranging from tens to hundreds of nm and very high precision. Our method relies on the intense and very quick proton energy deposition, which induces in a bulk material an explosive boiling and produces nanocrystals that aggregate in a plasma plume composed by atoms detached from the proton-irradiated surface. the properties of the obtained particles depend on the deposited proton energy and on the duration of the thermodynamical process. Suitably controlling the irradiated dose allows fabricating nanocrystals of a specific size with low polydispersity that can easily be isolated in order to obtain a monodisperse nanocrystal solution. Molecular Dynamics simulations confirm our experimental results.

show abstract

All-optical structuring of laser-driven proton beam profiles

Cited by 19 publications

References 66 publications

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline

Ultra-Fast High-Precision Metallic Nanoparticle Synthesis using Laser-Accelerated Protons

Contact Info

Product

Resources

About