All Solid Sate Potentiometric Sensors for the Measurement of Paroxetine in Pharmaceutical Formulation

A new methodology was applied for the designing potentiometric membrane sensors. An electrochemically polymerized Poly(Pyrrole)s (PPy) film was applied as a solid contact-ion to electron transducer on the surface of a pencil graphite electrode (PGE) to make an all-solid-state ion selective electrode (CP-ASS-ISE) for the determination of Tramadol Hydrochloride. A thin layer of a PVC membrane containing synthesized ion-pair as the active element and suitable plasticizer was then placed on the surface of the conducting polymer layer to prepare the sensor. The suggested sensor showed a Nernstian response (a slope of 57.17 mV per decade) over the concentration range of 1.0×10 −6 to 1.0×10 −1 mol L -1 . The Tramadol sensor had a low detection limit of 7.4×10 −7 mol L -1 with response time of less than 10s in the concentrated solutions. The working pH range of the sensor was 2.0-7.0. Finally, the proposed sensor used for the Tramadol assay in some pharmaceutical tablets.

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All Solid Sate Potentiometric Sensors for the Measurement of Paroxetine in Pharmaceutical Formulation

Cited by 3 publications

References 41 publications

Fabrication of an All Solid State (ASS) Polymeric Membrane Sensor (PME) for Tramadol and Its Application

Fabrication of an All Solid State (ASS) Polymeric Membrane Sensor (PME) for Tramadol and Its Application

Recent advances in solid-contact ion-selective electrodes: functional materials, transduction mechanisms, and development trends

Conducting Polymer All Solid State Potentiometric Sensor for the Tramadol Assay

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