Polybrominated diphenyl ethers (PBDEs) are one class of brominated flame retardants (BFRs). Although studies have reported the occurrence of PBDEs in freshwater fish species from several locations, to our best knowledge, there was no comprehensive data on PBDEs in foods of animal origin, such as pork, egg, and milk samples from interior areas of China, where pork and eggs are the major constituents of diet. The levels of PBDEs (BDE-28, 47, 99, 100, 153, 154, and 183) were determined in samples of animal-derived foods widely consumed by the population of Hubei in east-central China and the middle reaches of the Yangtze River. Two hundred six samples of animal-derived foods were randomly acquired in 17 sites of Hubei in 2010. The highest medium concentration of ∑7PBDEs was found in chicken eggs (0.191 ng/g wet weight (ww)), followed by duck eggs (0.176 ng/g ww), pork (0.050 ng/g ww), carps (0.047 ng/g ww), and cow milk (0.013 ng/g ww). The estimated dietary intake of Σ7PBDEs for a standard adult of 60 kg body weight based on medium and 95th percentile concentrations with consumption of animal-derived foods in Hubei province were 157.5 and 1960.3 pg/kg body weight/day, respectively. Chicken eggs (65.9 %) and pork (23.4 %) were the largest contributors to dietary intake of ∑7PBDEs through animal-derived foods. The same PBDE sources were exposed in Hubei province via principal component analysis (PCA), and the particular congener profile in samples of animal-derived foods revealed the possible exposure history of octa-BDEs and penta-BDEs in the local region. The large margins of exposure (MOE) calculated following the European Food Safety Authority (EFSA) approach for three important congeners, BDE-47, BDE-99, and BDE-153, indicated that the estimated dietary exposures were unlikely to be a significant health concern to in Hubei.