2022
DOI: 10.1007/s12031-022-01977-0
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All-Trans Retinoic Acid–Preconditioned Mesenchymal Stem Cells Improve Motor Function and Alleviate Tissue Damage After Spinal Cord Injury by Inhibition of HMGB1/NF-κB/NLRP3 Pathway Through Autophagy Activation

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Cited by 12 publications
(18 citation statements)
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“…Morteza demonstrated that the HMGB1/Nuclear factor of κB (NF-κB) signaling pathway was activated after SCI. Downregulation of the levels of HMGB1 and p-NF-κB suppressed the secondary phase SCI injuries in rats [16].…”
Section: Introductionmentioning
confidence: 93%
“…Morteza demonstrated that the HMGB1/Nuclear factor of κB (NF-κB) signaling pathway was activated after SCI. Downregulation of the levels of HMGB1 and p-NF-κB suppressed the secondary phase SCI injuries in rats [16].…”
Section: Introductionmentioning
confidence: 93%
“…ATRA-MSC therapy was shown to have significant therapeutic effects on the injured spinal cord and regulate excessive neuroinflammation via inhibiting the NLRP3 inflammasome pathway and activating autophagy. 166 A homeostatic mechanism known as autophagy, which is a cellular process that removes unnecessary or damaged components in a lysosome-dependent manner, is activated in a number of pathological conditions such as inflammation, cancer, and neurodegenerative diseases. 167 A proper balance between the essential innate inflammatory responses and the avoidance of uncontrolled inflammation is achieved by autophagy and inflammasome interplay.…”
Section: Mscs and Their Exosomes Alleviate Cns Diseases By Targeting ...mentioning
confidence: 99%
“…SCI is characterized by sensory, motor and autonomic nerve dysfunction ( 16 ) mediated by complex and diverse pathophysiological processes, including neuroinflammation, neuronal death, glial scar formation and axonal regeneration ( 17 20 ). The concentration of HMGB1 in the injured area increases rapidly and lasts for a long time ( 21 31 ), and it not only aggravates injury by playing the role of an inflammatory cytokine, but it also promotes the recovery of the injured spinal cord.…”
Section: Introductionmentioning
confidence: 99%