Allele Distributions and Frequencies of the Six Prion Protein Gene (PRNP) Polymorphisms in Asian Native Cattle, Japanese Breeds, and Mythun (Bos frontalis)

Shimogiri, Takeshi; Msalya, George; Myint, Si Lhyam; Okamoto, Susumu; Kawabe, Kentaro; Tanaka, Kazuaki; Mannen, Hideyuki; Minezawa, Mitsuru; Namikawa, Takao; Amano, Takashi; Yamamoto, Yoshio; Maeda, Yoshizane

doi:10.1007/s10528-010-9364-x

Cited by 12 publications

(10 citation statements)

References 25 publications

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“…Conversely, in three Chinese indigenous breeds (Qinchuan, Nanyang and Jiaxian), the allele 'I' frequency was higher than allele 'D' frequency. For 12-bp indel locus, the allele 'I' frequency was higher than allele 'D' frequency in all studied breeds population, which was in contradiction to the previous reported results in US sires, Mongolia native and other cattle breeds population (Seabury et al 2004;Shimogiri et al 2010). Notably, allele 'I' at these two locus was higher in Chinese indigenous breeds, and previous reports revealed that the 12-bp insertion and 23-bp insertion polymorphisms all increased the resistance to BSE (Sander et al 2005;Juling et al 2006;Haase et al 2007;Xue et al 2008;Msalya et al 2010).…”

Section: Discussioncontrasting

confidence: 99%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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Polymorphisms in the prion protein gene (PRNP) have been linked with the occurrence of transmissible spongiform encephalopathies and the expression of some phenotypic traits in healthy animals including cattle. The aim of this study was to verify the 23-bp insertion/deletion (indel) within promoter region and the 12-bp indel within intron 1 of PRNP, as well as to evaluate their associations with growth traits. Two loci of PRNP were genotyped in 1558 healthy Chinese cattle sampled from 6 indigenous breeds. Moreover, phenotypic records for growth were used to find the relationship between PRNP polymorphisms and phenotypic performance. The results confirmed the occurrence of these two indel polymorphisms in the analysed breeds. Association analysis showed that the 23-bp indel was significantly related to the body length and heart girth in 18-months-old Nanyang cattle. The 12-bp indel was significantly related to the growth traits in three cattle breeds, such as the body weight in Xia'nan cattle, the daily gained weight in 12-months-old Nanyang cattle and the cannon circumference and rump length in Ji'an cattle. These findings indicated that these two indels may affect bovine growth traits, which could benefit to healthy cattle selection and breeding through marker-assisted selection.

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Section: Discussioncontrasting

confidence: 99%

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Yang

Zhang

Liu

et al. 2017

Journal of Applied Animal Research

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“…Given the low frequency of the 14-bp indel within the 3 0 UTR in cows and artificial insemination sires of the USA (0.006 and zero, respectively), 23 in Vietnamese native cattle (0.18) and Laos native populations of Asian origin (0.22) 27 (Table 1), we hypothesized that the frequency of the 14-bp indel of the 3 0 UTR in PRNP gene may be low in Chinese cattle breeds. We used an ME strategy to detect the allele frequency in all individuals.…”

Section: Discussionmentioning

confidence: 99%

“…10,28 However, they did not corroborate the results presented by Shimogiri, 10 who reported the frequency in Japanese Brown of more than 0.10. 27 Those discrepancies might be due to the small sample size (n D 64). Overall, the 14-bp indel within the PRNP gene was characterized by low frequency in main Chinese cattle breeds.…”

Section: Discussionmentioning

confidence: 99%

Application of mathematical expectation (ME) strategy for detecting low frequency mutations: An example for evaluating 14-bp insertion/deletion (indel) within the bovine PRNP gene

Yang

Zhang

Liu

et al. 2016

Prion

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ABSTRACT. The detection method based on the mathematical expectation (ME) strategy is fast and accuracy for low frequency mutation screening in large samples. Previous studies have found that the 14-bp insertion/deletion (indel) variants of the 3 0 untranslated region (3 0 UTR) within bovine PRNP gene have been characterized with low frequency (5%) in global breeds outside China, which has not been determined in Chinese cattle breeds yet. Therefore, this study aimed to identify the 14-bp indel within PRNP gene in 5 major Chinese indigenous cattle breeds and to evaluate its associations with phenotypic traits. It was the first time to use ME strategy to detect low frequency indel polymorphisms and found that minor allele frequency was 0.038 (Qinchuan), 0.033 (Xianan), 0.013 (Nanyang), 0.003 (Jiaxian), and zero (Ji'an), respectively. Compared to the traditional detection method by which the sample was screened one by one, the reaction time by using the ME method was decreased 62.5%, 64.9%, 77.6%, 88.9% and 66.4%, respectively. In addition, the 14-bp indel was significantly associated with the growth traits in 2 cattle breeds, with the body length of Qinchuan cattle as well as the body weight and waistline of Xianan cattle. Our results have uncovered that the method based on ME strategy is rapid, reliable, and cost-effective for detecting the low frequency mutation as well as our findings provide a potential valuable theoretical basis for the marker-assisted selection (MAS) in beef cattle.

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“…The E211K change is analogous to the human E200K amino acid replacement, which is a trigger of the development of heritable human TSE [8]. Recently, new information regarding the frequency and distribution of bovine PRNP indel polymorphisms has been reported for Vietnamese local cattle and native Chinese cattle [17, 27, 29], and the information suggests that Asian local breed cattle have a variety of genetic divergences within the PRNP for potential association with BSE.…”

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confidence: 99%

Genetic Diversity in the Prion Protein Gene (<i>PRNP</i>) of Domestic Cattle and Water Buffaloes in Vietnam, Indonesia and Thailand

Uchida

Heriyanto²,

Chalermchaikit

et al. 2014

The Journal of Veterinary Medical Science

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There has been an accumulation of information on frequencies of insertion/deletion (indel) polymorphisms within the bovine prion protein gene (PRNP) and on the number of octapeptide repeats and single nucleotide polymorphisms (SNPs) in the coding region of bovine PRNP related to bovine spongiform encephalopathy (BSE) susceptibility. We investigated the frequencies of 23-bp indel polymorphism in the promoter region (23indel) and 12-bp indel polymorphism in intron 1 region (12indel), octapeptide repeat polymorphisms and SNPs in the bovine PRNP of cattle and water buffaloes in Vietnam, Indonesia and Thailand. The frequency of the deletion allele in the 23indel site was significantly low in cattle of Indonesia and Thailand and water buffaloes. The deletion allele frequency in the 12indel site was significantly low in all of the cattle and buffaloes categorized in each subgroup. In both indel sites, the deletion allele has been reported to be associated with susceptibility to classical BSE. In some Indonesian local cattle breeds, the frequency of the allele with 5 octapeptide repeats was significantly high despite the fact that the allele with 6 octapeptide repeats has been reported to be most frequent in many breeds of cattle. Four SNPs observed in Indonesian local cattle have not been reported for domestic cattle. This study provided information on PRNP of livestock in these Southeast Asian countries.

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Allele Distributions and Frequencies of the Six Prion Protein Gene (PRNP) Polymorphisms in Asian Native Cattle, Japanese Breeds, and Mythun (Bos frontalis)

Cited by 12 publications

References 25 publications

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

The evaluation of 23-bp and 12-bp insertion/deletion within the PRNP gene and their effects on growth traits in healthy Chinese native cattle breeds

Application of mathematical expectation (ME) strategy for detecting low frequency mutations: An example for evaluating 14-bp insertion/deletion (indel) within the bovine PRNP gene

Genetic Diversity in the Prion Protein Gene (<i>PRNP</i>) of Domestic Cattle and Water Buffaloes in Vietnam, Indonesia and Thailand

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