Allelic diversity of MICA gene and MICA/HLA-B haplotypic variation in a population of the Murcia region in southeastern Spain

MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059

“…Several HLA-B-MICA haplotypes previously observed in a Japanese population were found in this population, which mainly included HLA-B*51-MICA*00901 and HLA-B*48-MICA*Del [11]. Haplotypes characteristic of Caucasian populations were also uncovered, such as HLA-B*07-MICA*00801and HLA-B*57-MICA*017 [10,16,17]. These findings are important from an anthropologic perspective, and will help determine the feasibility of international donor and recipient registries for sharing solid organs and stem cells among ethnically different populations.…”

Distribution of MICA haplotypes in a Chinese Han population

“…A wide allelic distribution including 16 different MICA alleles was observed, among which MICA *010, MICA*002:01, MICA*008:01, and MICA*019 were predominant. Comparison of the allelic frequencies for MICA between our cohort and other populations, including Asians, Africans, and Caucasians [10,[13][14][15][16][17][18][19][20][21], indicated different distributions (Table 2). Whereas MICA*019 was observed as a high-frequency allele (14.93%), this allele was detected in only 1 to 3% of individuals from other populations.…”

Association analysis of MICA gene polymorphism and MICA-129 dimorphism with inflammatory bowel disease susceptibility in a Spanish population

“…Patients with CD and UC were classified according to Montreal classification for age at onset, disease location, and behavior [24]. Peripheral blood was also obtained from 154 unrelated randomly selected healthy Murcians, all of them Caucasoid, recruited at the University Hospital "Virgen de la Arrixaca" from Murcia Region, in the Southeast of Spain, as previously published [25]. All patients and controls gave their informed consent to the collection and storage of blood, isolation of DNA, and determination of the gene polymorphisms, before their inclusion in this study.…”