Allelic variants of <i>XRCC1</i> and <i>XRCC3</i> repair genes and susceptibility of oral cancer in Brazilian patients

Reis, Mariana Bisarro dos; Guembarovski, Roberta Losi; Ribeiro, Enilze Maria de Souza Fonseca; Cavalli, Iglenir João; Morita, Maria Celeste; Ramos, Gyl Henrique Albrecht; Oliveira, Benedito Valdecir de; Mizuno, Lauro Toyoshi; Rogatto, Sílvia Regina; Cólus, Ilce Mara de Syllos

doi:10.1111/j.1600-0714.2012.01192.x

Cited by 29 publications

(15 citation statements)

References 26 publications

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“…The distribution of the genotypes of the XRCC1 Arg194Trp, Arg280His, and Arg399Gln polymorphisms in the control groups was consistent with the HWE, except in three of the studies. Two of these studies were related to the Arg194Trp polymorphism [37], [43], and one was related to the Arg399Gln polymorphism [51]. These studies were excluded from the subsequent analyses.…”

Section: Resultsmentioning

confidence: 99%

“…This finding may have happened by chance, or may have resulted from different gene frequencies in the different populations; the MAF of XRCC1 Arg194Trp is 0.26 for Asians but only 0.09 for Caucasians. A number of studies have reported the association between the XRCC1 Arg194Trp polymorphism and oral cancer risk [10], [39], [41], [43], [44], [51]. It has been reported that the XRCC1 Arg194Trp polymorphism may result in decreased repair efficiency of DNA damage, and the repair deficit may eventually increase an individual's susceptibility to oral cancer [53], [54].…”

Section: Discussionmentioning

confidence: 99%

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Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis

Liu

Yin

et al. 2014

PLoS ONE

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BackgroundPrevious studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphic variants on HNC risk.MethodsThe PubMed and EMBASE databases were searched for genetic association studies on the XRCC1 Arg194Trp, Arg399Gln, and Arg280His polymorphisms and HNC risk. (The most recent search was conducted on 20 August, 2013.) Twenty-six studies were identified and meta-analysis was performed to evaluate the association between the polymorphism and HNC by calculating combined odds ratios and 95% confidence intervals.ResultsNo significant association was found under the allelic, homozygous, heterozygote, and dominant genetic models in the overall comparison. Further, no significant association between the XRCC1 Arg399Gln and Arg280His polymorphisms and HNC risk was detected under the four genetic models in subgroup analyses based on ethnicity, cancer site, and whether or not the studies had been adjusted for cigarette smoking and alcohol. However, in stratified analyses based on cancer site, a significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer under the allelic, heterozygote, and dominant models. The XRCC1 Arg194Trp polymorphism was significantly associated with HNC risk in studies that were adjusted for smoking and alcohol under the homozygous and heterozygote models.ConclusionThe meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. Further studies with larger samples are needed to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis

Liu

Yin

et al. 2014

PLoS ONE

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“…To address this problem, subgroup analysis was conducted in this study by HWE in controls. When the study [13] that significantly deviated from HWE was excluded from this present analysis, we did not observe a substantial modification of the results, suggesting that this factor might not have effects on the overall estimates in the current meta-analysis.…”

Section: Discussionmentioning

confidence: 70%

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

et al. 2013

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BackgroundEpidemiologic studies have reported the association of X-ray repair cross-complementary group 1 (XRCC1) Arg399Gln polymorphisms with susceptibility to squamous cell carcinoma of the head and neck (HNSCC). However, the results were conflictive rather than conclusive. The purpose of this study was to clarify the association of XRCC1 Arg399Gln variants with HNSCC risk.MethodsSystematic searches were performed through the search engines of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database. Summary odds ratio (OR) with 95% confidence intervals (CI) was computed to estimate the strength association.ResultsOverall, we did not observe any association of XRCC1 Arg399Gln polymorphisms with HNSCC risk in total population (OR = 0.95, 95% CI: 0.76–1.19 for Gln/Gln vs. Arg/Arg, OR = 1.05, 95% CI: 0.92–1.20 for Arg/Gln vs. Arg/Arg, and OR = 1.03, 95% CI: 0.90–1.18 for Gln/Gln+Arg/Gln vs. Arg/Arg) based on 18 studies including 3917 cases and 4560 controls. In subgroup analyses, we observed an increased risk of XRCC1 399 Arg/Gln genotype for HNSCC in Caucasians (OR = 1.20, 95% CI: 1.00–1.44) and Gln/Gln genotype for larynx squamous cell carcinoma (OR = 1.63, 95% CI: 1.10–2.40). We did not observe any association between XRCC1 Arg399Gln variants and HNSCC risk in additional subgroup analyses.ConclusionThe results from this present meta-analysis suggest that XRCC1 Arg399Gln variants may contribute to HNSCC risk among Caucasians and to the risk of larynx squamous cell carcinoma. Further, well-designed studies with larger sample sizes are required to verify our findings.

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“…The variant rs861539 in XRCC3 , characterized by a C–T transversion at position 722, affects protein repair function, leading to genetic instability and DNA DSB accumulation (Lindh, Rafii, Schultz, Cox, & Helleday, ; Matullo et al, ; Nowacka‐Zawisza et al, ; Pierce, Johnson, Thompson, & Jasin, ). Previous studies have demonstrated that these genetic variants in RAD51 and XRCC3 contribute to development and progression in acute myeloid leukemia and carcinomas in several locations (Avci, Ergen, Bireller, Ertugrul, & Cakmakoglu, ; Dos Reis et al, ; Farnebo et al, ; Flores‐Obando, Gollin, & Ragin, ). However, their role in oral and oropharyngeal SCC is not well established.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

Santos

Matos

et al. 2018

Oral Diseases

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Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients

Abstract: These results suggest that allelic variants of XRCC1 and XRCC3 are not suitable markers for susceptibility to carcinomas of the oral cavity and are also not related to the later stages of such tumors.

Cited by 29 publications

References 26 publications

Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis

Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

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