Allelic variation of BAT-26 and BAT-40 poly-adenine repeat loci in North Indians

Mukherjee, Moumita; Vaish, Minal; Mittal, Rama Devi; Mittal, Balraj

doi:10.3892/ijmm.9.1.91

Cited by 9 publications

(10 citation statements)

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“…BAT26 determines MSI with 99.5% efficiency in colorectal cancer (CRC) suggesting it alone may be sufficient for determining MSI 21 . Some concerns have arisen as BAT26 is polymorphic in some populations including the American black and Indian populations 22–24 . Furthermore, germline polymorphisms that affect BAT26 analysis 23 have been described but occur rarely (0.8% of the Caucasian population).…”

Section: Discussionmentioning

confidence: 99%

Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic variables

Honoré¹,

Hanson²,

Andrew³

2006

Int J Gynecol Cancer

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This study of 218 patients with endometrioid endometrial carcinoma explores the relationship between microsatellite instability (MSI) as established by the BAT26 method and the common pathologic variables of prognostic and therapeutic significance. MSI was positively correlated with grade, associated endometrial atrophy, squamous metaplasia, isthmic involvement, depth of myoinvasion, vascular invasion-associated changes, extrauterine tumor spread, and extramyometrial angiolymphatic spread. There was no significant correlation with carcinoma developing in adenomyosis, mucinous metaplasia, tumor size, cornual involvement, cervical extension, uterine serosal involvement, and targeted lymphoid response. The positive correlations are discussed in terms of molecular genetics.

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Section: Discussionmentioning

confidence: 99%

Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic variables

Honoré¹,

Hanson²,

Andrew³

2006

Int J Gynecol Cancer

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“…Out of he motifs studied, BAT-26 & BAT-40, the mononucleotide poly A repetitive loci have been shown to exhibit polymorphism [9]. The change either borderline or major deletions/ insertions at this loci is compared in tumor tissue of the same patient with the normal tissue in colorectal tumors [8].…”

Section: Methodsmentioning

confidence: 99%

Microsatellite instability as prognostic marker in bladder tumors: a clinical significance

et al. 2005

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Background: Carcinoma of urinary bladder is one of the leading causes of death in India. Successful treatment of bladder cancer depends on the early detection & specific diagnostic approaches. In the present study, microsatellite instability (MSI) has been evaluated as a prognostic marker in patients with superficial urinary bladder cancer in lower urinary tract for determining risk of recurrence.

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“…Studies done to determine the utility of the BAT-40 poly(A) n microsatellite in microsatellite instability studies have highlighted the polymorphic nature of this microsatellite (44)(45)(46)(47)(48). This characteristic of the BAT-40 repeat has been exploited in the present study to analyze whether there is an association between the BAT-40 containing region of the chromosome 1 with thyroid cancer susceptibility.…”

Section: Resultsmentioning

confidence: 93%

Thyroid Cancer Susceptibility and THRA1 and BAT-40 Repeats Polymorphisms

Baida

Farrington

Galofré³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although genetic and environmental factors have been identified in the etiology of thyroid cancer, the specific genetic implications in sporadic thyroid tumors are poorly understood but, as in other common cancers, low-penetrance susceptibility genes are believed to be crucial in the tumorigenesis processes. Here, we have carried out a casecontrol study to investigate whether there is an association between THRA1 CA repeat or BAT-40 A repeat polymorphisms and thyroid cancer risk. The THRA1 repeat resides in the thyroid hormone receptor-a1 gene, which is associated with thyroid cancer and whose expression depends on the THRA1 repeat size. We also analyzed the BAT-40 repeat that maps to chromosome 1, a region known to be involved in thyroid cancer. This repeat is located in the 3-b-hydroxysteroid dehydrogenase gene that is associated with prostate cancer susceptibility. The THRA1 repeat was genotyped in 212 thyroid cancer patients and 141 controls of a Spanish population. From these individuals, 207 patients and 138 controls were also analyzed for the BAT-40 marker. No significant difference in the THRA1 allele distribution between patients and controls was found, although short alleles (<128 bp) might have some protective effect on thyroid cancer risk of carriers (odds ratio, 0.50; 95% confidence interval, 0.22-1.13; P = 0.094). By contrast, the BAT-40 allele distribution in patients was significantly different with respect to control (P = 0.035). Essentially, the difference were found in the genotypes involving the 111-to 115-bp allele range, which seem to be associated with a protective effect on thyroid cancer susceptibility in the studied population (odds ratio, 0.18; 95% confidence interval, 0.01-0.57; P = 0.02). Therefore, our results indicate that the BAT-40 containing region and to a less extend the thyroid hormone receptor-a1 gene are related to thyroid cancer susceptibility. To our knowledge, this is the first study reporting the identification of genetic factors for thyroid cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2005;14(3):638 -42)

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Allelic variation of BAT-26 and BAT-40 poly-adenine repeat loci in North Indians

Cited by 9 publications

References 0 publications

Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic variables

Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic variables

Microsatellite instability as prognostic marker in bladder tumors: a clinical significance

Thyroid Cancer Susceptibility and THRA1 and BAT-40 Repeats Polymorphisms

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