Allergen and Endotoxin Exposure, Infection, and Breastfeeding in Early Life, and Recurrent Wheezing in Children: 30-month Follow-up of a Cohort Study

Rullo, Vera Esteves Vagnozzi; Arruda, L. Karla; Zampolo, A.S.; Cardoso, Mra; Nóbrega, Fernando José de; Scala, Cíntia Sayuri Kurokawa La; Oliveira, Lucila Camargo Lopes de; Naspitz, Charles K.; Solé, Dírceu

doi:10.1016/j.jaci.2007.12.1069

Cited by 2 publications

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“…(4)(5)(6) In addition, the risk factors found, such as male gender, history of pneumonia, maternal smoking during pregnancy, day care center attendance, low maternal level of education, early weaning, multiple episodes of cold, first viral infection prior to 3 months of age, siblings in the household, and history of asthma in the nuclear family (parents or siblings), are in accordance with the findings obtained in previous studies. (4,5,(10)(11)(12)(13)(14) Various population-based studies have attempted to determine the clinical importance of wheezing in childhood. Its complexity makes prevalence rates vary, depending on the time of data collection, the area, and the population assessed, as well as on the research tool used.…”

Section: Discussionsupporting

confidence: 87%

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Prevalência e fatores de risco para sibilância no primeiro ano de vida

et al. 2010

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Objective: To determine the prevalence of and the risk factors for wheezing in infants under one year of age and residing in the city of Porto Alegre, Brazil. Methods: This was a cross-sectional study and is part of a multicenter, multinational project. The parents or legal guardians of the infants were interviewed at primary health care clinics or during home visits. We used a standardized questionnaire, validated for use in Brazil. Potential risk factors were assessed by means of a Poisson regression model with robust variance estimation, using the Wald test to determine the significance of each variable in the model. Results: The sample comprised 1,013 infants. The majority of those were male (53%), and the mean age was 13.5 ± 1.2 months. In 61% of the infants, there had been at least one episode of wheezing, which had recurred at least three times in one third of those infants. The mean age at the first episode of wheezing was 5.16 months (median, 5 months). Over 40% of the infants with wheezing visited emergency rooms due to wheezing, and 17% of those were hospitalized at least once in the first year of life because of this symptom. In the multivariate analysis, the risk factors for wheezing were as follows: male gender; history of pneumonia; maternal smoking during pregnancy; day care center attendance; low maternal level of education; early weaning; multiple episodes of cold; first viral infection prior to 3 months of age; existence of siblings; and history of asthma in the nuclear family. Conclusions: The prevalence of wheezing is high among infants in the city of Porto Alegre. We identified various risk factors for wheezing in infants.Keywords: Respiratory sounds/epidemiology; Asthma; Infant; Risk factors. ResumoObjetivo: Determinar a prevalência e os fatores de risco para sibilância em lactentes com até um ano de idade e residentes na cidade de Porto Alegre (RS). Métodos: Estudo transversal, parte de um projeto multicêntrico e multinacional. Os pais ou responsáveis dos lactentes foram entrevistados em unidades básicas de saúde ou durante visitas domiciliares. Utilizamos um questionário padronizado e validado para uso no Brasil. Potenciais fatores de risco foram avaliados mediante um modelo de regressão de Poisson com estimativa robusta de variância, utilizando-se o teste de Wald para determinar a significância de cada variável no modelo. Resultados: Foram incluídos 1.013 lactentes. A maioria era do sexo masculino (53%), e a média de idade foi de 13,5 ± 1,2 meses. Houve pelo menos um episódio de sibilância em 61% dos lactentes, e houve recorrência do sintoma em pelo menos três ocasiões em um terço daqueles lactentes. A média de idade no início dos episódios de sibilância foi de 5,16 meses (mediana, 5 meses). Mais de 40% dos lactentes com sibilância visitaram serviços de urgência em função desse sintoma, e 17% tiveram pelo menos uma hospitalização por essa causa no primeiro ano de vida. Na análise multivariada, os fatores de risco para sibilância foram os seguintes: sexo masculino, história de pn...

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Section: Discussionsupporting

confidence: 87%

“…(4,5) In a cohort of 188 neonates monitored for one year in Chile, episodes of wheezing were identified in 80% of the cases, half presenting recurrence. (6) The etiologic diagnosis of wheezing in small infants varies considerably, and, in most instances, the clinical manifestations are associated with viral infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalência e fatores de risco para sibilância no primeiro ano de vida

et al. 2010

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“…(5) Our research group studied a cohort of children residing in the city of São Paulo and at high risk for developing asthma. (6) We found that 52% of the children evaluated presented recurrent wheezing by the end of the 30-month follow-up period.…”

Section: Editorialmentioning

confidence: 73%

Sibilância na infância

Solé

2008

J. bras. pneumol.

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Allergen and Endotoxin Exposure, Infection, and Breastfeeding in Early Life, and Recurrent Wheezing in Children: 30-month Follow-up of a Cohort Study

Cited by 2 publications

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Prevalência e fatores de risco para sibilância no primeiro ano de vida

Prevalência e fatores de risco para sibilância no primeiro ano de vida

Sibilância na infância

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