Allergen Determination with Detection of Serum Specific IgE in Dogs with Atopic Dermatitis from Samsun and Vicinity

Barili, Öykü; Pekmezci, Didem

doi:10.30607/kvj.599782

Cited by 3 publications

(6 citation statements)

References 21 publications

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“…Previous studies on canines with AD (6, 40, 43, 44) have reported that the causative allergens associated with the etiology of the disease include house dust mite 1, house dust mite 2 (6,40,43,44), flea mite (40), food mite (6,44), flour mite, plant mite, rye pollen (6), grass pollen (6,43), and banana pollen (43). Upon allergen testing with serum-specific IgE, the present study identified the most prevalent allergens to be house mites type 1, house mites type 2, flea mites, plant and flour mites, pollen of hornbeam family trees, and food parasites (Lepidoglyphus).…”

Section: Resultsmentioning

confidence: 96%

“…The severity of pruritus in skin allergic reactions is important with regard to the occurrence of primary skin lesions (erythema, papule, and pustule) and secondary skin lesions (epidermal collarettes, crusting, peeling, alopecia, hyperpigmentation, and lichenification) during the course of the disease (13,19). Mites, lice, and flea infestations and allergens, such as lawn and grass pollen, have been reported to play a significant role in the etiology of AD (6,19,30,41,66,67). Various tests (allergen testing with serumspecific IgE and intradermal skin testing) can identify causative allergens involved in the etiology of the disease.…”

Section: Resultsmentioning

confidence: 99%

“…Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease that typically occurs as a result of hypersensitivity reactions in response to environmental allergens and an abnormal skin barrier (3,6,7,13,19,46,55).…”

mentioning

confidence: 99%

“…AD in dogs is characterized by pruritus with concomitant primary (erythema, papules, and pustules) and secondary skin lesions (epidermal collarettes, crusting, peeling, alopecia, hyperpigmentation, and lichenification). Pruritus and lesions commonly occur on the head, neck, chest, genital areas, and extremities (6,66).…”

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confidence: 99%

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Investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis

KATANALP,

KOÇHAN

2024

Medycyna Weterynaryjna

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The aim of this study was to present allergens involved in the etiology of atopic dermatitis (AD) in dogs, to determine and classify the clinical severity of the disease using the CADESI-4 and pruritus scores, to investigate changes in serum cytokine levels in dogs with AD and their relationship with clinical findings, and to investigate the effects of oclacitinib maleate on clinical improvement and serum cytokine levels. The material of the study consisted of 20 dogs diagnosed with AD and 10 healthy dogs. CADESI and pVAS scores were obtained from the patients, and blood samples were taken. Hematological analyses, specific allergen tests (polycheck), and ELISA analyses were performed. Oclacitinib maleate (Apoquel, Zoetis) was administered orally to the patient dogs at a dose of 0.5 mg/kg twice a day for 7 days. It was found that the most common allergens involved in the etiology of AD in dogs were house dust mites type 1, house dust mites type 2, and mold fungi, and the mean CADESI and pVAS scores for clinical findings such as pruritus, alopecia, erythema, and lichenification in dogs with AD were 48 and 5.15 respectively. When compared to the control group, an increase in the percentage of eosinophils (p < 0.05) and a decrease in serum IL-2 and IL-4 levels (p < 0.05) were detected. When compared to other groups, it was found that the mean serum IL-4 levels (p < 0.05) were low and IL-13 levels (p < 0.05) were high in the group with severe clinical findings. It was determined that the use of oclacitinib maleate resulted in clinical improvement and caused an increase in the mean serum IL-2 levels (p < 0.05) and a decrease in IL-31 and IL-33 levels (p < 0.05). Oclacitinib maleate (Apoquel, Zoetis) was found to be an effective and reliable drug that can be used in the treatment of the disease, but it was concluded that the duration of use should be extended.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis

KATANALP,

KOÇHAN

2024

Medycyna Weterynaryjna

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“…Ö. Barili and D. Pekmezci (2019) show that in atopic dermatitis in dogs, specific Ig E levels are above the threshold. They note that genetic factors affect the level of Ig E in dogs.…”

Section: Table 5 Biochemical Parameters In the Blood Serum Of Dogs Un...mentioning

confidence: 95%

Efficacy of treatment of small animals with triamcinolone-based medications for atopic dermatitis

Paliy,

Rodionova,

Pavlichenko

et al. 2024

Scientific Horizons

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Among the diseases of small pets, skin diseases are one of the leading ones. Atopic dermatitis is a common skin condition in small pets, which, according to veterinarians’ estimates, affects 10-15% of dogs and 7-18% of cats. Depending on the allergens involved, clinical signs can be seasonal or non-seasonal, and the disease usually requires lifelong treatment. The purpose of this study was to investigate the therapeutic efficacy of treating atopy in dogs and cats with the use of triamcinolone-based veterinary medications (oral suspension). Standard clinical, haematological, biochemical, and immunological methods were used in the study. The increased content of total immunoglobulin E (Ig E) in the blood of experimental animals before treatment (Group I – 3.4 times, and Group II – 3.9 times compared to the control) indicates the presence of an allergic response in the body. It was found that the tested veterinary medications do not substantially affect the haematological parameters of dogs and cats when administered orally, and in therapeutic doses do not have a toxic effect on the functional state of the liver and kidneys. It was proved that on Day 4 of use of oral suspension No. 1 and No. 2 based on triamcinolone (1%) acetonide and a complex of B vitamins in a therapeutic dosage, an improvement in the general clinical condition of animals was recorded. On Day 8 of treatment, dogs and cats in experimental Groups I and II showed improvement in skin condition: a reduction in the lesion area, absence of redness, scratching, and exfoliation. The general clinical condition of the skin of the experimental animals stayed unchanged from Day 8 to Day 12. The developed oral suspensions have a pronounced anti-allergic effect and improve the skin condition of small pets (dogs and cats) with atopic dermatitis

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Detection of Serum Allergen-Specific IgE in Atopic Dogs Tested in Northern Italy: Preliminary Study

Tommaso

Luciani

Crisi

et al. 2021

Animals

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Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. IgE is detected using Serum Allergen-Specific IgE test (SAT) in order to identify allergens. The present study aims to identify the environmental allergens in atopic dogs living in Northern Italy using SAT. The screening SAT (sSAT), using a monoclonal antibody cocktail-based ELISA to identify indoor and outdoor allergens, was performed. In all positive samples, an anti-IgE monoclonal antibody ELISA test was performed to extend panel of allergens. Out of 117 selected dogs, 69 were included in the study; 71% were positive and 29% were negative to sSAT. Among the 49 positive sSAT, 53% were positive for both indoor and outdoor, 38.8% only for indoor, and 8.2% only for outdoor allergens. This is the first study on the frequency of allergens involved in CAD in Italy using SAT. IgE hypersensitivity in atopic dogs of Northern Italy is usually associated with indoor allergens, primarily house dust mites. Among the outdoor allergens, an important role was played by Rumex acetosa. Polysensitization also commonly occurs. Therefore, since the numerous factors affect the IgE positivity in CAD, specific panels for geographical areas should be considered and re-evaluated at time intervals.

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Allergen Determination with Detection of Serum Specific IgE in Dogs with Atopic Dermatitis from Samsun and Vicinity

Cited by 3 publications

References 21 publications

Investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis

Investigation of the effects of oclacitinib maleate on clinical improvement and serum cytokine levels in dogs with atopic dermatitis

Efficacy of treatment of small animals with triamcinolone-based medications for atopic dermatitis

Detection of Serum Allergen-Specific IgE in Atopic Dogs Tested in Northern Italy: Preliminary Study

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