2016
DOI: 10.1111/cea.12607
|View full text |Cite
|
Sign up to set email alerts
|

Allergen extract vs. component sensitization and airway inflammation, responsiveness and new‐onset respiratory disease

Abstract: Measurement of IgE sensitization to cat allergen components would seem to have a higher clinical value than extract-based measurement, as it related better to airway inflammation and responsiveness and had a higher prognostic value for the development of asthma and rhinitis over a 12-year period.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
20
1
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 17 publications
(22 citation statements)
references
References 45 publications
(83 reference statements)
0
20
1
1
Order By: Relevance
“…In a recent population‐based study, an independent association between IgE to Fel d 1 and both FeNO and airway responsiveness was seen, which might appear inconsistent with our findings. However, it is important to keep in mind the fundamental difference between a population‐based study that compares asthmatic and non‐asthmatic individuals, and our study, which investigates associations within a group of asthmatics.…”
Section: Discussioncontrasting
confidence: 99%
“…In a recent population‐based study, an independent association between IgE to Fel d 1 and both FeNO and airway responsiveness was seen, which might appear inconsistent with our findings. However, it is important to keep in mind the fundamental difference between a population‐based study that compares asthmatic and non‐asthmatic individuals, and our study, which investigates associations within a group of asthmatics.…”
Section: Discussioncontrasting
confidence: 99%
“…The identification of IgE to profilins, polcalcins or other panallergens requires further workup checking IgE sensitizations to major, species-specific allergenic molecules before prescribing allergen immunotherapy (AIT) [18]. The study by Patelis et al [16] suggests that a CRD may refine a diagnosis based on allergen extracts and potentially increases the prognostic value for new onset of rhinitis and asthma.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, a 'negative' IgE-extract assay should always correspond to 'negative' outcomes in molecular-based IgE assays covering all the extract's components. Nevertheless, in this issue of Clinical and Experimental Allergy, Patelis et al [16] describe frequent conditions that serum IgE antibodies of allergic subjects recognize allergenic extracts of different sources (e.g. cat) but not their inherent components (e.g.…”
Section: Discrepancies Between Allergen Extract and Allergen Moleculementioning
confidence: 99%
“…). Sensitization to both cat extract and any cat component but not sensitization to only extract was independently associated with more bronchial responsiveness and higher FeNO . Results from studies on the BAMSE cohort where the MEDALL customized version of the ISAC chip was used show that sensitization to Fel d 1 and Can f 1 in childhood and polysensitization to either cat or dog allergen molecules predict cat and dog allergy cross‐sectionally and longitudinally better than IgE to cat or dog extract .…”
Section: Microarray For Broad Sensitization Profilingmentioning
confidence: 97%
“…A high level of sIgE to Bet v 1 or sensitization to many PR-10 proteins at 4 years of age was associated with increased incidence and persistence of AR up to age 16 [18]. IgE sensitization to cat and timothy components had higher clinical value as they associated independently with new onset of rhinitis and asthma, compared with traditional extract-based methods [53].…”
Section: Investigating the Allergic March And Assessing The Risk For mentioning
confidence: 99%