Allergen immunotherapy in atopic dermatitis

Ridolo, Erminia; Martignago, Irene; Riario-Sforza, Gian Galeazzo; Incorvaia, Cristoforo

doi:10.1080/1744666x.2018.1401469

Cited by 18 publications

(30 citation statements)

References 51 publications

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“…While AD lesions were improved by HDM avoidance based on such measures [27,28], reductions in HDM levels had no effect on skin symptoms [29]. The effects of HDM allergen immunotherapy on AD lesions have been investigated by several groups [30,31]. Ridolo et al reported that the treatment of AD with the causative aeroallergen can be used as an add-on therapy in selected patients who are non-responsive to conventional therapy [30].…”

Section: House Dust Mites (Hdm)mentioning

confidence: 99%

“…The effects of HDM allergen immunotherapy on AD lesions have been investigated by several groups [30,31]. Ridolo et al reported that the treatment of AD with the causative aeroallergen can be used as an add-on therapy in selected patients who are non-responsive to conventional therapy [30].…”

Section: House Dust Mites (Hdm)mentioning

confidence: 99%

“…Epicutaneous patch testing with pollen allergen extract induced eczematous lesions in patients with AD [36,37]. In grass pollen-exposed subjects, the serum levels of chemokine (C-C motif) ligand 17 (CCL17), CCL22, and IL-4 were significantly increased [30]. The preventative measures that can be used against pollen allergies include brushing pollen off clothes, washing your face when arriving home, wearing glasses and masks, and using air conditioning with pollen filters (Table 3) [1,2,14].…”

Section: Pollenmentioning

confidence: 99%

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Atopic Dermatitis: Identification and Management of Complicating Factors

Tamagawa‐Mineoka

Katoh

2020

IJMS

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Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease, associated with impaired skin barrier function and an atopic background. Various complicating factors, such as irritants, aeroallergens, food, microbial organisms, contact allergens, sweat, and scratching can induce the development of AD symptoms. Irritants, including soap/shampoo and clothes, can cause itching and eczematous lesions. In addition, young children with AD tend to become sensitized to eggs, milk, or peanuts, while older children and adults more often become sensitized to environmental allergens, such as house dust mites (HDM), animal dander, or pollen. Serum-specific IgE levels and skin prick test reactions to food tend to show high negative predictive values and low specificity and positive predictive values for diagnosing food allergy. On the other hand, AD adult patients tend to have severe skin symptoms and exhibit high HDM-specific IgE levels. Microbial organisms, e.g., Staphylococcus aureus and Malassezia furfur, might contribute to the pathogenetic mechanisms of AD. While sweat plays a major role in maintaining skin homeostasis, it can become an aggravating factor in patients with AD. Furthermore, scratching often exacerbates eczematous lesions. Several patient-specific complicating factors are seen in most cases. The identification and management of complicating factors are important for controlling AD.

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Section: House Dust Mites (Hdm)mentioning

confidence: 99%

Section: House Dust Mites (Hdm)mentioning

confidence: 99%

Section: Pollenmentioning

confidence: 99%

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Atopic Dermatitis: Identification and Management of Complicating Factors

Tamagawa‐Mineoka

Katoh

2020

IJMS

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“…While some studies suggest a positive effect for AE, there is conflicting evidence whether desensitization might influence AE in a positive way. 92 Ongoing and future efforts will need to determine which subgroups or endotypes of AE might benefit best. 93,94 Also in case of allergic contact dermatitis (ACD), evidence is conflictive regarding the impact on the course of AE.…”

Section: Are Allergies Relevant For the Pathogenesis Of Ae?mentioning

confidence: 99%

New biological treatments for asthma and skin allergies

Eyerich

Metz

Bossios

et al. 2019

Allergy

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Allergies are typically endemic, complex and heterogeneous diseases with a high impact at quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil granulocytes, mast cells and humoral factors such as IgE are key drivers of allergic diseases. Fighting allergic diseases knows three strategies: prevention, symptomatic and causative therapy. While remarkable progress was made in understanding molecular events in allergies as a prerequisite for effective prevention and desensitization, this review article focuses on the most efficient symptomatic treatments—that is using more and more specific antibodies neutralizing particular immune pathways. We highlight and classify recent and upcoming developments in the three prototype chronic allergic diseases allergic asthma, chronic spontaneous urticaria and atopic eczema. In all three examples, biologics such as dupilumab or omalizumab become reliable and efficient therapeutic options. Finally, we give an outlook how a diagnostic and therapeutic workflow might look like in the near future for these three major burdens of society.

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“…Allergen immunotherapy (AIT) is a treatment method whose effectiveness and reliability have been proven in cases where disease symptoms persist despite drug therapy and preventive care. It has been used as the most effective treatment since the early 1900s to cure allergic asthma (AA), allergic rhinitis (AR) and atopic dermatitis (AD) associated with respiratory system allergic sensitivity as well as anaphylaxis caused by venom (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Allergen Immunotherapy on Serum Periostin Levels in Children with Allergic Rhinitis

Uçaryılmaz¹,

Emsen²,

Dikener³

et al. 2019

Asthma Allergy Immunol

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Objective: Periostin, an extracellular matrix protein, is related to the eosinophilic airway inflammation. There is no specific marker in allergen immunotherapy to evaluate clinical response. We aimed to investigate the serum periostin levels in the children who receive allergen immunotherapy. Materials and Methods:Sixteen patients between 8-18 years (12.7±2.8 years) with allergic rhinitis and/or asthma due to grass pollen hypersensitivity and 30 healthy subjects (11.7±2.6 years) were included. Demographic data, eosinophil counts, skin prick tests and the specific IgE levels of the patients are recorded. Symptom scores, visual analog scales, medication scores were determined and the serum periostin levels were measured in the beginning, 4th and 12th months of the allergen immunotherapy. Results:The symptom scores for rhinitis in the 4th month showed significant improvements in all of the patients (p<0.05). Nine patients with allergic rhinitis accompanied by asthma, showed significant improvements in 12th month symptom score for asthma (p=0.018). A significant correlation was detected between the initial serum periostin levels and the symptom scores for the eye (r=0.668, p=0.005). No significant difference was found in serum periostin levels between the patient and the control groups. There were no significant differences in serum periostin levels in 4 th and 12 th months compared to the ones in the beginning. Conclusion:In this study, there were no significant differences in serum periostin levels of children during the allergen immunotherapy. The association of serum periostin levels with symptom scores for the eye needs to be confirmed in more children with allergic rhinoconjunctivitis.

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Allergen immunotherapy in atopic dermatitis

Cited by 18 publications

References 51 publications

Atopic Dermatitis: Identification and Management of Complicating Factors

Atopic Dermatitis: Identification and Management of Complicating Factors

New biological treatments for asthma and skin allergies

The Effect of Allergen Immunotherapy on Serum Periostin Levels in Children with Allergic Rhinitis

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