Allergens in Corticosteroid Vehicles

Coloe, Jacquelyn; Zirwas, Matthew J.

doi:10.2310/6620.2008.07054

Cited by 56 publications

(32 citation statements)

References 4 publications

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“…However, we found that >40% of SSO‐positive patients had a history of atopic dermatitis. Although this did not reach statistical significance relative to SSO‐negative patients, this tendency could be attributable to increased exposure to SSO as an emulsifier in topical steroid preparations for recurrent eczema . Genetically impaired skin barrier function, such as loss‐of‐function mutations in the filaggrin gene, could also be of relevance for the risk of developing contact allergy to SSO, as recently shown in a case report from our department .…”

Section: Discussionmentioning

confidence: 99%

Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

Bennike

Johansen

2016

Contact Dermatitis

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Section: Discussionmentioning

confidence: 99%

Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

Bennike

Johansen

2016

Contact Dermatitis

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“…More broadly, allergies to excipients contained in topical steroids have also been well documented [86] - with these allergens being contained in both originator and generic preparations. Saccharose, an excipient with potential side effects, was seen in generic preparations of phenobarbitol used to treat epilepsy in Mauritania [87].…”

Section: A Brief History Of Pharmaceutical Regulationsmentioning

confidence: 99%

A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study

Dunne

Shannon

Dunne

et al. 2013

BMC Pharmacol Toxicol

189

164

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Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years, primarily as a cost saving measure in healthcare provision. Generic medicines are typically 20 to 90% cheaper than originator equivalents. Our objective is to provide a high-level description of what generic medicines are and how they differ, at a regulatory and legislative level, from originator medicines. We describe the current and historical regulation of medicines in the world’s two main pharmaceutical markets, in addition to the similarities, as well as the differences, between generics and their originator equivalents including the reasons for the cost differences seen between originator and generic medicines. Ireland is currently poised to introduce generic substitution and reference pricing. This article refers to this situation as an exemplar of a national system on the cusp of significant health policy change, and specifically details Ireland’s history with usage of generic medicines and how the proposed changes could affect healthcare provision.

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“…[12] Aggravation of an inflammatory dermatosis or lack of response to TC may occur due to allergic contact dermatitis to the steroid molecule, the vehicle or the preservative. [13,14] TCs of lower potency such as hydrocortisone or desonide (commonly used in children) have a higher potential of producing allergic contact dermatitis than the midpotent or superpotent TCs. [15] Steroid dependence manifested as burning and itching with dryness and erythema may occur when TCs are attempted to be withdrawn after prolonged use.…”

Section: Adverse Effects Of Tc In Childrenmentioning

confidence: 99%

Use and abuse of topical corticosteroids in children

Coondoo¹,

Chattopadhyay²

2014

Indian J Paediatr Dermatol

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and Class V (hydrocortisone butyrate). Steroids of low potency are more suitable for the pediatric age group and include desonide, clobetasone and fluocinolone acetonide (Class VI) and hydrocortisone (Class VII). Table 1 lists the TC approved by Food and Drug Administration (FDA) for children.Potency of TC is principally measured by the method of vasoconstriction assay. Other assays of glucocorticoid potency are done by experimentally inducing inflammation to suppress erythema and edema and the psoriasis bioassay, which is done to quantify the effect of the TC on psoriatic lesion. [2] Weaker (low potent) topical steroids are suitable for use in areas where the skin is thin and sensitive such as the face, eyelids, armpits and diaper area including the groins, buttocks and perianal skin. Moderately potent steroids are used for various dermatitis such as atopic dermatitis and allergic contact dermatitis as well as in other disorders such as vitiligo, polymorphous light eruptions and discoid lupus erythematosus. Steroids of higher potency are used in diseases such as psoriasis, lichen planus hypertrophicus, lichen simplex chronicus and lichen amyloidosus where the skin is thickened and penetrability is decreased. [3] The effects and side-effects of TCs depend mainly on the thickness of skin, potency of the TC as well ABSTRACT Topical corticosteroids (TC) have been in use for more than half a century and are useful for the treatment of various infl ammatory disorders in all age groups including children. Children, however, form a special age group because their skin, being more thin and tender, is more susceptible to the side-effects of the drug. Hence dermatologists must be aware of this special situation where TC must be prescribed with utmost caution. Counselling of parents and others handling the children is also imperative for judicious use of the drug. Planned withdrawal of the drug as early as possible helps in avoiding tachyphylaxis and most of the side-effects of the drug.

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Allergens in Corticosteroid Vehicles

Cited by 56 publications

References 4 publications

Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study

Use and abuse of topical corticosteroids in children

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