Allergens in mother's milk: Tolerisation or sensitization

Kilburn, Sally; Pollard, C.; Bevin, S.; Hourihane, Jonathan; Warner, John O.; Dean, Taraneh

doi:10.1016/s0271-5317(98)00114-6

Cited by 7 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concentrations of antigens in breast milk, however, seem not to be directly associated with the incidence and symptoms of allergy in the infant (Cant et al 1985). Antigens in breast milk may also be associated with tolerance induction rather than sensitisation (Kilburn et al 1998). Induction of oral tolerance to dietary antigens may depend on several factors such as the dose and degradation of antigens (Barone et al 2000).…”

Section: Dietary Antigens: Sensitisation or Tolerance?mentioning

confidence: 99%

Probiotics: on-going research on atopic individuals

et al. 2002

View full text Add to dashboard Cite

The challenge for the modern health care system is to fight against the increasing prevalence of atopic disease. The introduction of scientifically composed probiotic functional foods for prophylactic or therapeutic purposes could be one solution. Probiotics are live microbial food supplements or components of bacteria which have beneficial effects on human health. Specific strains have been demonstrated to exert powerful anti-pathogenic, anti-inflammatory and anti-allergic effects. The hygiene hypothesis suggests that atopic disease may arise from a lack of counterbalancing microbial exposure at an early age. The initial compositional development of the gut microflora is considered a key determinant of the development of both the immune responder phenotype and normal gut barrier functions. The regulatory role of probiotics in human allergic disease was first emphasised in the demonstration of a suppressive effect on lymphocyte proliferation and interleukin-4 generationin vitro. Subsequently, a significant improvement in the clinical course of atopic eczema was reported in infants given a probiotic-supplemented diet. The potential of probiotics to reduce the risk of atopic disease has recently been demonstrated in a double-blind, placebo-controlled study: probiotics administered pre- and postnatally for 6 months to at-risk subjects reduced the prevalence of atopic eczema to half of that observed in infants receiving placebo. Ongoing research is directed towards the development of novel techniques to characterise the gut microflora. Future research will clarify the mechanisms to control specific physiological processes in the evolution of atopic disease in at-risk populations or in the management of allergic diseases.

show abstract

Section: Dietary Antigens: Sensitisation or Tolerance?mentioning

confidence: 99%

Probiotics: on-going research on atopic individuals

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Eight intervention studies [13][14][15][16][17][18][19][20] investigated the use of maternal dietary restriction during lactation as a strategy to prevent allergy in high-risk infants. Lactating women were asked to exclude between one (cow's milk) [18] and five (cow's milk, egg, peanut, fish and beef/soybean) [13,14] food proteins from their diet.…”

Section: Studies Of Antigen Avoidance Diets To Prevent Allergy In Brementioning

confidence: 99%

“…Only five of the relevant studies were randomized, and none of these trials reported adequate concealment of allocation [13,14,16-18], an important factor in limiting selection bias, especially in trials where the participants know their group allocation. Furthermore, blinding of the clinical examinations to establish the presence of atopic disorders was only reported in five studies [14,[16][17][18]20]. Sample sizes were also small (n ¼ 16-60 per group), except in one trial [16], where 288 mother/infant pairs completed the trial.…”

Section: Studies Of Antigen Avoidance Diets To Prevent Allergy In Brementioning

confidence: 99%

“…In terms of study design, only four studies [14,15,18,20] were specifically designed to investigate the effects of maternal dietary restriction during lactation on childhood atopic disease. In two studies [13,19] the maternal dietary restrictions were undertaken during both pregnancy and lactation.…”

Section: Studies Of Antigen Avoidance Diets To Prevent Allergy In Brementioning

confidence: 99%

See 1 more Smart Citation