Allergic bronchopulmonary aspergillosis: Indian scenario

Prasad, Rajendra; Kacker, Rishabh; Gupta, Nikhil

doi:10.4103/ijaai.ijaai_37_19

Cited by 1 publication

(4 citation statements)

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“…Among the previously published literature, the most common age group of ABPA mentioned in India is 20-40 years. 9 The mean age in our study was 37.66 years, which is comparable with earlier studies.…”

Section: Discussionsupporting

confidence: 92%

“…On examination of the chest, wheezing and diffuse crepts are the common findings in previous studies, but tachypnea, cyanosis, and respiratory distress and failure may also be seen. 9 It was also observed in our study.…”

Section: Discussionsupporting

confidence: 85%

“…The clinical diagnosis of ABPA requires a high degree of suspicion as the majority of the patients present with cough, sputum production, and dyspnea, thus, mimicking pneumonia. 9 Similarly, the majority of our patients presented with cough (89.9%) and respiratory distress (44.4%), while patients in advanced stages of the disease presented with respiratory failure (9.1%). On clinical examination, crepitation was present in 33.3% of the cases and wheezing in 55.6%.…”

Section: Discussionsupporting

confidence: 52%

“…Aspergillus is a ubiquitous mold found in indoor and outdoor environments. 9 There are many species of Aspergillus. Among these, the most significant cause of human infections is A. fumigatus, which causes various lung conditions.…”

Section: Discussionmentioning

confidence: 99%

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Clinicodemographic, radiological, and immunological profiles of allergic bronchopulmonary aspergillosis in a tertiary care institute in Eastern India

2022

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Background: Allergic bronchopulmonary aspergillosis (ABPA) is a type of hypersensitivity reaction to mold Aspergillus fumigatus, especially common in patients with bronchial asthma. However, systemic data regarding the clinicodemographic, radiological, and immunological profiles of patients is sparse, particularly from the eastern India.Methods: This is a prospective observational study done over a year, from January 2021 to December 2021, in patients visiting the pulmonary medicine outpatient department (OPD) with symptoms similar to ABPA. Following the clinical examination, routine blood investigations, serum total immunoglobulin E (IgE) test, Aspergillus-specific IgE test, spirometry, and chest radiology (chest X-ray/high resolution CT scan) were done. ABPA was diagnosed using the 2013 ISHAM-ABPA working group criteria. Data were analyzed using statistical package for the social sciences (SPSS) software version 2021 against different categories of eosinophil count.Results: A total of 99 patients, 74 male and 25 female, were diagnosed with ABPA. The mean age±standard deviation (SD) was 37.66±15.411. Most of the patients (93) were asthmatic. Chest radiology was normal in 52.5% of the cases. The absolute eosinophil count (mean±SD) was 3963.61±5333.363. The mean±SD serum IgE and Aspergillus-specific IgE levels were 8061.07±8374.274 and 7.5826±12.693, respectively.Conclusions: There was no significant association between lung function abnormalities and eosinophil count. Serology variant (ABPA-S) was the most common finding among ABPA patients. A high eosinophil count was associated with a high incidence of bronchiectasis and hyper attenuated mucus (HAM), although the severity of bronchiectasis was not directly related to a higher peripheral eosinophil count. There may be some correlation between the peripheral eosinophil count and the total IgE but not between the peripheral eosinophil count and the Aspergillus-specific IgE.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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