Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications

Capucilli, Peter; Hill, David R.C.

doi:10.1007/s12016-019-08733-0

Cited by 65 publications

(53 citation statements)

References 207 publications

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“…It might be speculated that high expression of IL‐13 and IL‐5 might promote ductal goblet metaplasia in the salivary glands, increase secretion of mucinous protein, and disrupt the barrier function of the ductal epithelium. IL‐4/IL‐13 pathway inhibitors demonstrate gratifying efficacy in the treatment of EoE and asthma 18,23 . Whether they are suitable as a therapy for ES is worthy of further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…The clinicopathological features of ES were akin to those of asthma and eosinophilic esophagitis (EoE). First, the symptoms of regional organs were characterized by luminal stenosis comorbid with allergy, which manifested as salivary duct stenosis in ES, airway narrowing in asthma, 17 and esophageal stricture in EoE 11,18 . Second, the lesion mainly involved the ductal system and spared the parenchyma, characterized histologically by eosinophil‐predominant inflammation 4,11,19 .…”

Section: Discussionmentioning

confidence: 99%

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Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy

et al. 2020

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Objectives To investigate the clinical, laboratory, radiological, histopathological, and immunohistochemical features, and the expression of allergy‐related cytokines in eosinophilic sialodochitis (ES). Methods Thirty‐eight patients diagnosed with chronic obstructive sialadenitis (COS) who had undergone glandular excision or incisional biopsy were enrolled. Seventeen patients with comorbid atopic disease and increased ductal tissue eosinophils comprised the ES group, while 21 patients comprised the COS group. The clinicopathological features and allergy‐related cytokine expression were compared between groups. Results The ES group frequently involved multiple, bilateral major salivary glands, and the number of glands was significantly greater than the COS group (2.8 ± 1.1 vs. 1.2 ± 0.4, P < .001). Serum immunoglobulin (Ig) E was elevated in 91% of patients in ES group (419 ± 357 kU/L) and peripheral blood eosinophil was significantly greater compared with the COS group (7.6% ± 4.6% vs. 2.5% ± 1.4%, P < .001). Histologically, eosinophil infiltration in ES group was observed around the main and interlobular ducts (50 ± 39/high power field [HPF]). Follicular hyperplasia (76%), epithelial mucous metaplasia (82%), and mucus plugs with eosinophils (41%) were observed. IgE‐positive cell count was 20.7 ± 18.3/HPF and tryptase‐positive mast cell count was 23.5 ± 15.1/HPF, which was significantly greater than the respective cell counts in COS group, which mainly infiltrated around the ducts. The levels of interleukin‐4, interleukin‐13, and eotaxin in tissue were significantly greater in ES than the COS group. Conclusions The clinicopathological characteristics of ES are significantly different from COS and ES might have an allergy‐related pathogenesis. Level of Evidence 4 Laryngoscope, 131:E800–E806, 2021

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy

et al. 2020

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“…Moreover, the association between EoE and other allergic conditions is well established and might be a potential further reason for FTT and undernutrition in EGIDs children. Children with EGIDs have an excessive prevalence of atopic dermatitis, IgE-mediated food allergy, asthma, and allergic rhinitis, potentially affecting the expected growth [ 51 ]. Moreover, several reports have suggested that EGIDs may also be frequently associated with chronic non-allergic comorbidities that might compromise adequate child growth, feeding behavior, and quality of life [ 46 ].…”

Section: Undernutrition and Failure To Thrive In Egids Patientsmentioning

confidence: 99%

Malnutrition in Eosinophilic Gastrointestinal Disorders

et al. 2020

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Primary eosinophilic gastrointestinal disorders (EGIDs) are emerging chronic/remittent inflammatory diseases of unknown etiology, which may involve any part of the gastrointestinal (GI) tract, in the absence of secondary causes of GI eosinophilia. Eosinophilic esophagitis is the prototype of eosinophilic gastrointestinal disorders and is clinically characterized by symptoms related to esophageal inflammation and dysfunction. A few studies have assessed the nutritional status of patients with eosinophilic gastrointestinal disorders, showing conflicting results. This review summarizes the current evidence on the nutritional status of patients with EGIDs, focusing on the pediatric point of view and also speculating potential etiological mechanisms.

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“…In both children and adult populations, the prevalence has also increased. It is the leading cause of dysphagia in children and young adults [20].…”

Section: Epidemiological Aspectsmentioning

confidence: 99%

An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications

Khan

Guo

et al. 2020

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Background: Eosinophilic esophagitis (EoE) is an immune-mediated clinicopathological condition characterized by esophageal infiltration with eosinophils resulting in chronic inflammation and stricture. Summary: The recent increase in the incidence of EoE and the characteristic presentation of symptoms with difficulty swallowing and food bolus impaction has raised key concerns of clinicians as well as researchers. EoE often presents with dysphagia, food impaction, nausea, regurgitation or vomiting, and decreased appetite. It is more common in males, affecting both adults and children. The causative manner of this condition is complex and multifactorial. Throughout recent years, researchers have made a significant contribution to understanding the pathogenesis of EoE, genetic background, natural history, work on allergy, and standardization in the evaluation of disease activity. There is relatively high prevalence of EoE among the population, emphasizing the importance of this disease. Key messages: Esophageal involvement with eosinophils may be manifested as isolated or with coexisting conditions and should be taken into consideration in the differential diagnosis. This study aimed to provide gastroenterologists with novel insights into the evaluation of esophageal involvement with eosinophils and to pay special attention to the etiological factors, coexisting clinical diseases, and complications.

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Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications

Cited by 65 publications

References 207 publications

Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy

Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy

Malnutrition in Eosinophilic Gastrointestinal Disorders

An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications

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