Allergic Contact Dermatitis

Kostner, Lisa; Anzengruber, Florian; Guillod, Caroline; Recher, Mike; Schmid‐Grendelmeier, Peter; Navarini, Alexander A.

doi:10.1016/j.iac.2016.08.014

Cited by 114 publications

(111 citation statements)

References 33 publications

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“…An estimated 15–20% of the general population are affected by contact dermatitis, and regarding occupational diseases, irritant contact dermatitis and allergic contact dermatitis (ACD) are among the most common of these medical conditions . Although an impressive amount of research has identified two distinct pathophysiological phases in the development of ACD, namely sensitization and elicitation, the complex immune mechanisms behind them are incompletely understood …”

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confidence: 99%

The frequency of specific contact allergies is reduced in patients with psoriasis

et al. 2018

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The frequency of specific contact allergies is reduced in patients with psoriasis

et al. 2018

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“…Unlike irritant contact dermatitis, which results from an irritant chemical causing a direct toxic effect on the skin, ACD is a delayed type IV hypersensitivity reaction to a hapten or antigen. 61 Unlike other hypersensitivity reactions, ACD is not dependent on antibodies but relies on a T H 1 response to an antigen presented by an antigen-presenting cell. It is dependent on 2 phases: the induction phase, whereby the immune system is sensitized to an antigen, and the elicitation phase, whereby the immune response is triggered on rechallenge of the allergen.…”

Section: Allergic Contact Dermatitismentioning

confidence: 99%

Pruritus in allergy and immunology

Yang

Kim

2019

Journal of Allergy and Clinical Immunology

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Although evolutionarily conserved to expel ectoparasites and aid in the clearance of toxins and noxious environmental stimuli from the host, the type 2 immune response can become pathologic in the setting of a variety of allergic disorders. Itch can be a behavioral extension of type 2 immunity by evoking scratching and, in the setting of disease, can become chronic and thus highly pathologic as well. Classically, our understanding of itch mechanisms has centered around the canonical IgE-mast cell-histamine axis. However, therapies aimed at blocking the histaminergic itch pathway have been largely ineffective, suggesting the existence of nonhistaminergic itch pathways.Indeed, recent advances in itch biology have provided critical new insight into a variety of novel therapeutic avenues for chronic itch in the setting of a number of allergic disorders. Here we highlight how these new developments will likely inform the problem of pruritus in a variety of well-established and emerging conditions in the field of allergy. (J Allergy Clin Immunol 2019;144:353-60.)

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“…Allergic contact dermatitis (ACD) is the most common cause of occupationally related skin disease, affecting as many as 1 in 7 individuals annually (Kostner et al, 2017;Thyssen et al, 2009). Although the conceptual pathologic process in ACD is straightforward-an inappropriate or exaggerated immune response to skin contact with an otherwise innocuous substance-the precise immunologic mechanisms mediating this pathologic process are complex and incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity

Brys

Rodriguez-Homs

Suwanpradid

et al. 2020

Journal of Investigative Dermatology

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The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate gd T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.

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Allergic Contact Dermatitis

Cited by 114 publications

References 33 publications

The frequency of specific contact allergies is reduced in patients with psoriasis

The frequency of specific contact allergies is reduced in patients with psoriasis

Pruritus in allergy and immunology

Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity

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