Allergic contact dermatitis: a significant environmental and occupational skin disease

Olusegun, Olufunmilayo A; Martincigh, Bice S.

doi:10.1111/ijd.15502

Cited by 21 publications

(18 citation statements)

References 78 publications

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“…Allergic contact dermatitis (ACD) is a common inflammatory skin disease caused by exposure to contact allergens ( Olusegun and Martincigh, 2021 ). Banvolgyi et al successfully depleted the TRPV1-mediated sensory component from the capsaicin-sensitive neurons by systemic resiniferatoxin (RTX) pretreatment or genetic deletion, resulting in an enhanced inflammatory response.…”

Section: Trpv1 and Inflammatory Skin Diseasesmentioning

confidence: 99%

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Xiao

Sun²,

Zhao³

et al. 2023

Front. Pharmacol.

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TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.

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Section: Trpv1 and Inflammatory Skin Diseasesmentioning

confidence: 99%

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Xiao

Sun²,

Zhao³

et al. 2023

Front. Pharmacol.

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“…Most of these allergic skin disorders are chronic, inflammatory, and proliferative [15]. e skin usually turns red, pigmented, pruritic, dry, and cracked [16] during disease development. Moreover, the interaction between chronic inflammation and senescence is attracting increasing attention [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Properties of Physalis alkekengi L. Extracts In Vitro and In Vivo: Potential Application for Skin Care

Wang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Inflammatory skin disorders are becoming major issues threatening public health with increasing prevalence. This study was to evaluate the anti-inflammatory, antioxidant, and antisenescent activities of traditional folk medicinal plant, Physalis alkekengi L. extracts to alleviate skin inflammation and its possible mechanisms. Methods. Lipopolysaccharides (LPS)-treated murine macrophages RAW264.7 and human skin keratinocytes HaCaT were incubated with the plant extracts, respectively. The production of nitric oxide (NO) was tested by using Griess reagents. The activity of nitric oxide synthase (NOS) was detected through a fluorescence microplate reader. Reactive oxygen species (ROS) production and cell apoptosis were quantified by flow cytometry. The proinflammatory cytokines were measured using ELISA and qRT-PCR. Human skin fibroblasts (HFF-1) were coincubated with D-galactose (D-gal) and the plant extracts. The senescence associated-galactosidase (SA-β-gal) was stained to evaluate cellular senescence. The senescence-associated secretory phenotype (SASP), IL-1β, was measured through ELISA. The mRNA of IL-1α in SLS-stimulated and PGE2 in UV-radiated 3D skin models were detected by qRT-PCR. In vivo ROS production and neutrophil recruitment in CuSO4-treated zebrafish models were observed by fluorescence microscopy. Inflammation-related factors were measured by qRT-PCR. Results. In vitro, Physalis alkekengi L. significantly reduced NO production, NOS activity, cell apoptosis, transcription of TNF-α, IL-6, IL-1β and ROS production. These plant extracts markedly attenuated SA-β-gal and IL-1β and downregulated the production of IL-1α and PGE2. In vivo, the plant extracts dramatically dampened ROS production, the number of neutrophils, and proinflammatory cytokines. Conclusions. Cumulatively, this work systematically demonstrated the anti-inflammatory, antioxidant, and antisenescent properties of Physalis alkekengi L. and proposed the possible roles of Physalis alkekengi L. in inflammatory signaling pathways, providing an effective natural product for the treatment of inflammatory skin disorders.

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“…The discharge of effluents contaminated with dyes without treatment affects the health of water bodies because it reduces the photosynthetic capacity of sub-aquatic plants, increases COD and causes eutrophication of surface waters [10]. Likewise, the toxic properties of some dyes have been confirmed, including carcinogenic [11], mutagenic [12], allergic and dermatological [13] effects. Even at trace levels (<1 mg/L), these compounds have adverse health effects [9].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Azo-Anionic Dyes in a Solution Using Modified Coconut (Cocos nucifera) Mesocarp: Kinetic and Equilibrium Study

Tovar

Villabona-Ortíz

González-Delgado

2021

Water

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The effect of adsorbent dose and initial concentration on removing the azo-anionic dyes Congo Red andtartrazine present in a synthetic aqueous solution was studied using natural cellulose (CC) and modified cationic cellulose (MCC) from coconut mesocarp. Three levels of adsorbent dosage (5, 8 and 12 mg/L) and initial concentration (40, 70 and 100 mg/L) were used. Cetyl trimethyl ammonium chloride (CTAC) was used as a modifying agent. TGA and DSC showed that the extracted cellulose was of good quality, composed mostly of cellulose with lignin and hemicellulose traces, and 8% moisture. The FTIR spectrum showed the effectiveness of the modification in the structure of the material with symmetric deformation of the C6H6-Cl group in 1472 cm−1 present in the CTAC. It was found that decreasing the adsorbent dosage and increasing the initial concentration favored the dyes’ adsorption capacity on the two bioadsorbents. Tartrazine removals of 5.67 mg/g on CC and 19.61 mg/g on MCC were achieved, and for CR of 15.52 mg/g on CC and 19.99 with MCC with removal percentages over 97% with the quaternized biomass in all cases. The kinetic and equilibrium study was carried out to identify the mechanisms involved in the adsorption process. The Freundlich model can describe the equilibrium isotherm data of tartrazine on CC and MCC. In contrast, those of CR is defined by the Langmuir and Dubinin–Radushkevic models for CC and MCC, respectively Adsorption kinetics showed that equilibrium was reached at 30 min, with rapid adsorption in the initial minutes with the removal of about 97% of the contaminant in the first 5 min; fitting to kinetic models showed that the kinetics of tartrazine on CC was fitted by Elovich (R2 = 0.756), and on MCC the Elovich (R2 = 0.887) and pseudo-second-order (R2 = 0.999) models. Removing CR on CC was fitted by pseudo-first-order, pseudo-second-order and Elovich models (R2 > 0.98), and when using MCC, all models show a good fitting with R2 = 0.99 in all cases.

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Allergic contact dermatitis: a significant environmental and occupational skin disease

Cited by 21 publications

References 78 publications

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Anti-Inflammatory and Antioxidant Properties of Physalis alkekengi L. Extracts In Vitro and In Vivo: Potential Application for Skin Care

Adsorption of Azo-Anionic Dyes in a Solution Using Modified Coconut (Cocos nucifera) Mesocarp: Kinetic and Equilibrium Study

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